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    Article

    Bacterial metabolic state more accurately predicts antibiotic lethality than growth rate

    Growth rate and metabolic state of bacteria have been separately shown to affect antibiotic efficacy1–3. However, the two are interrelated as bacterial growth inherently imposes a metabolic burden4; thus, determi...

    Allison J. Lopatkin, Jonathan M. Stokes, Erica J. Zheng… in Nature Microbiology (2019)

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    Article

    Discovering small-molecule senolytics with deep neural networks

    The accumulation of senescent cells is associated with aging, inflammation and cellular dysfunction. Senolytic drugs can alleviate age-related comorbidities by selectively killing senescent cells. Here we scre...

    Felix Wong, Satotaka Omori, Nina M. Donghia, Erica J. Zheng… in Nature Aging (2023)