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Open AccessIncreased lethality in influenza and SARS-CoV-2 coinfection is prevented by influenza immunity but not SARS-CoV-2 immunity
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing coronavirus disease 2019 (COVID-19) pandemic. The continued spread of SARS-CoV-2 increases the probability of influenza/...
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Article
Open AccessPost-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exhibits high levels of mortality and morbidity and has dramatic consequences on hu...
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Open AccessA single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge
The COVID-19 pandemic caused by SARS-CoV-2 imposes an urgent need for rapid development of an efficient and cost-effective vaccine, suitable for mass immunization. Here, we show the development of a replicatio...
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Open AccessInnate immune response in neuronopathic forms of Gaucher disease confers resistance against viral-induced encephalitis
Both monogenic diseases and viral infections can manifest in a broad spectrum of clinical phenotypes that range from asymptomatic to lethal, suggesting that other factors modulate disease severity. Here, we ex...
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Article
Open AccessInduction of the type I interferon response in neurological forms of Gaucher disease
Neuroinflammation is a key phenomenon in the pathogenesis of many neurodegenerative diseases. Understanding the mechanisms by which brain inflammation is engaged and delineating the key players in the immune r...
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Article
RIPK3 as a potential therapeutic target for Gaucher's disease
Gaucher's disease is a lysosomal storage disease caused by mutations in the glucocerebrosidase gene. Now, Anthony Futerman and his colleagues report that the expression of proteins linked to a form of cell dea...