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Article
Effects of Acute Stress in Mice with 5-HT1A Receptors with Different Sensitivities to Chronic Activation by 8-OH-DPAT
Recombinant mouse strain B6.CBA-D13Mit76C (B6-M76C) and B6.CBA-D13Mit76B (B6-M76B), with 5-HT1A receptors with different sensitivities to chronic activation by agonist 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tet...
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Article
Investigation of the Brain Serotonin System Plasticity Using the Recombinant Mouse Lines Carring 1473G–Allele of Tryptophan Hydroxylase-2 Gene and Differing by the Distal Fragment of Chromosome 13 Containing 5-HT1A Receptor Gene
Abstract—In order to investigate the joint influence of C1473G polymorphism in the gene encoding the key enzyme for serotonin (5-HT) biosynthesis in brain – tryptophan hydroxylase-2, and the distal fragment (103,...
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Article
Expression of the DNA methyltransferase genes in silver foxes experimentally selected for domestication
Animal domestication is a model of a rapid evolutionary process. In experimental fox domestication, the time required for the emergence and fixation of specific evolutionary changes was reduced from thousands ...
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Article
Expression of catechol-O-methyltransferase (Comt), mineralocorticoid receptor (Mlr), and epithelial sodium channel (ENaC) genes in kidneys of hypertensive ISIAH rats at rest and during response to stress
Emotional stress plays a significant role in the processes of the development of arterial hypertension, especially in the presence of genetic predisposition. The origin and maintenance of hypertensive status d...
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Article
Aldosterone and stress-dependent arterial hypertension
Secretory activity of the adrenal cortex and hormonal reaction to emotional stress were examined in normotensive WAG and hypertensive ISIAH rats. Under nembutal narcosis (surgical stage), secretion of corticos...