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  1. Article

    Metabolic gardening

    E. C. Slater in Nature (2003)

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  2. Article

    Albert L. Lehninger (1917 – 1986)

    E.C. Slater in Nature (1986)

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    Article

    The mechanism of action of mitochondrial ATPase (ATP synthase)

    The F1 part of the ATP synthase contains 6 nucleotide binding sites, four of which can be occupied and covalently labeled with 8-azido-adenine nucleotides. The other two sites contain tightly bound nucleotides th...

    E. C. Slater, J. A. Berden, M. B. M. van Dongen in Journal of Protein Chemistry (1986)

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    Article

    Identification of the BAL-labile factor

    One of us has previously reported1 that treatment of the Keilin and Hartree heart–muscle preparation2 with 2,3-dimercaptopropanol (BAL), in the presence of air, leads to the complete inactivation of the succinate...

    E. C. Slater, S. de Vries in Nature (1980)

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    Article

    High-energy Forms of Cytochrome b

    SUB-MITOCHONDRIAL particles prepared from horse or ox heart contain two species of cytochrome b in equal amounts, one (bi) affected by antimycin and the other (b) not affected1–3. In addition to its well known in...

    E. C. SLATER, C. P. LEE, J. A. BERDEN, H. J. WEGDAM in Nature (1970)

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    Article

    Labelling Rates and Detection of Intermediates in Mitochondrial Phosphorylations and other Sequential Reactions

    BASED on his observation that mitochondrial protein-bound phosphohistidine becomes maximally labelled with added radioactive inorganic phosphate before maximum labelling of the mitochondrial ATP is reached, Pr...

    E. C. SLATER in Nature (1965)

  7. Article

    Oxidases and Related Oxidation-Reduction Systems

    E. C. SLATER in Nature (1964)

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    Article

    Effect of Heavy Water on Respiratory-chain Enzymes

    DURING radiobiological work on bacteria it was found by one of us (H. L.) that the effect of ionizing radiation (X-rays) is greatly potentiated if the bacteria are irradiated in a medium in which water is repl...

    H. LASER, E. C. SLATER in Nature (1960)

  9. Article

    Need for Inorganic Phosphate in Oxidations stimulated by Dinitrophenol

    Recently we have reported, in disagreement with the widely accepted view, that the maximal rate of oxygen uptake by respiring rat-liver or rat-heart mitochondria with glutamate as substrate is not obtained wit...

    P. BORST, E. C. SLATER in Nature (1960)

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    Need for Inorganic Phosphate in Oxidations stimulated by Dinitrophenol

    IN an experiment with a phosphorylating kidney -cyclophorase preparation Loomis and Lipmann1 discovered that 2,4-dinitrophenol could replace the inorganic phosphate necessary for a maximal rate of oxygen uptake w...

    P. BORST, E. C. SLATER in Nature (1959)

  11. Article

    Enzymes

    E. C. SLATER in Nature (1959)

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    Article

    Tocopherol Content of Heart-muscle Preparations

    THE possible role of vitamin E in respiratory enzyme systems has often been suggested; but supporting evidence of the actual presence of vitamin E in active enzyme preparations has not been published. We have ...

    J. BOUMAN, E. C. SLATER in Nature (1956)

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    Article

    Respiratory Chain Phosphorylation in Extracts of Azotobacter vinelandii

    RESPIRATORY chain phosphorylation has been demonstrated in crude extracts of a few bacterial species1–4, and in one case the extract was separated into three components which were all necessary for phosphorylatio...

    A. TISSIÉRES, E. C. SLATER in Nature (1955)

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    Article

    Phosphorylation coupled with the Oxidation of Ferrocytochrome c by Heart Sarcosomes

    Nielsen and Lehninger1 have recently demonstrated the incorporation of phosphorus-32 into organic phosphate during the aerobic oxidation of ferrocytochrome c by rat-liver mitochondria in the presence of adenosine...

    E. C. SLATER in Nature (1954)

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    Article

    Stabilization of Oxidative Phosphorylation in Heart-Muscle Sarcosomes

    FRESHLY prepared suspensions of the granular components of heart-muscle (sarcosomes1, interstitial granules2 or mitochondria3) are able to oxidize a number of intermediary metabolites, and to couple this oxidatio...

    E. C. SLATER, K. W. CLELAND in Nature (1952)

  16. Article

    'Cytochrome c1' of Yakushiji and Okuniki

    Yakushiji and Okuniki1 claimed to have demonstrated the existence of a new component (cytochrome c1 of the succinic oxidase system, acting between cytochromes b and c, that is, with the same function as the respi...

    E. C. SLATER in Nature (1949)

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  17. Article

    A Factor in Heart Muscle Required for the Reduction of Cytochrome c by Cytochrome b

    IT is well established1 that the intracellular respiratory complex catalysing the aerobic oxidation of succinate (the succinic oxidase system) includes the cytochrome system in addition to the specific enzyme ...

    E. C. SLATER in Nature (1948)

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    Article

    Effect of Sulphadiazine on the Metabolism of Aneurin in Animals

    IT is well established that some of the toxic effects of sulphonamides on animals fed purified diets are caused by inhibition of bacterial synthesis of some B vitamins in the intestine, with consequent develop...

    E. C. SLATER in Nature (1946)