499 Result(s)
within
English
Medicine & Public Health
Oncology
Dong-**ng Wang
Article
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Article
Bcl-2 protects cells from cytokine-induced nitric-oxide-dependent apoptosis
Cytokine-mediated cell death in tumor cells can be achieved through endogenous nitric oxide (NO) from within tumor cells or exogenous NO from either activated macrophages or endothelial cells. The purpose of ...
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Interaction of EphB2-tyrosine kinase receptor and its ligand conveys dorsalization signal in Xenopus laevis development
The Eph class is the largest family of receptor tyrosine kinases and has been shown to play various roles in neural development including axon pathfinding and neural crest migration. EphB2 associates with tran...
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αPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase
p21-activated kinase (PAK) is a common effector protein of the small GTPases Cdc42 and Rac, leading to the activation of downstream mitogen activated protein kinases. PAK also mediates polarized cytoskeletal c...
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Inactivation of farnesyltransferase and geranylgeranyltransferase I by caspase-3: Cleavage of the common α subunit during apoptosis
Caspase plays an important role in apoptosis. We report here that farnesyltransferase/geranylgeranyltransferase (FTase/GGTase)-α, a common subunit of FTase (α/βFTase) and GGTase I (α/βGGTase), was cleaved by casp...
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Long-Term Results and Quality-of-Life Outcomes in Patients With Transsphincteric Fistulas After Muscle-Filling Procedure
PURPOSE: This study was designed to evaluate long-term results and quality-of-life outcomes after the muscle-filling procedure for posterior transsphincteric fistulas. METHODS: A questionnaire was mailed to 2...
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Intracranial Ganglioglioma: Preoperative Characteristics and Oncologic Outcome after Surgery
In order to investigate the clinical characteristics, neuroimaging findings, pathological features, treatment, and outcomes, and to provide valuable guidance for the diagnosis and management of intracranial ga...
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MAD2-induced sensitization to vincristine is associated with mitotic arrest and Raf/Bcl-2 phosphorylation in nasopharyngeal carcinoma cells
Mitotic arrest deficient 2 (MAD2) is thought to be a key component of the mitotic checkpoint, which ensures accurate chromosome segregation. Reduced expression of MAD2 protein is associated with mitotic checkp...
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Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential
The RON receptor tyrosine kinase is a member of the MET proto-oncogene family that has been implicated in regulating motile-invasive phenotypes in certain types of epithelial cancers. The purpose of this study...
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Inhibition of cell transformation by resveratrol and its derivatives: differential effects and mechanisms involved
Resveratrol, a constituent of grapes and other foods, has been reported to be a potential cancer chemopreventive agent. Our previous study showed that the antitumor activity of resveratrol occurs through mitog...
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Stroma from different developmental stages of fetal liver has different effects on human mononuclear fraction of umbilical cord blood during ex vivo co-culture
Fetal liver (FL) has transient and intense hematopoietic activity during gestation. It has been shown that hematopoietic activity in FL begins at embryonic day (E)11, is maximal at E16 and rapidly ceases there...
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The C-terminal region of S100A4 is important for its metastasis-inducing properties
The EF-hand protein, S100A4, binds calcium ions and interacts specifically in vitro with protein targets. Elevated levels of S100A4 have been shown to produce a metastatic phenotype in independent models of breas...
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The effect of combining fast neutron and photon irradiation on the human osteosarcoma OS-732 cell line
To determine the lethal effect of combining fast neutron with photon radiation on the OS-732 cell line.
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Results of treating vertebral metastases by percutaneous vertebroplasty combined with interventional chemotherapy
Vertebral metastases are a common manifestation in patients with advanced cancer and treatment is often ineffective. This study was conducted to explore the efficacy of treating vertebral metastases by percuta...
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Apoptosis Rate and Objective Diagnosis of Drug Resistance of Ovarian Cancer Cell Lines
Objective: To investigate whether the change of drug resistance degree could be evaluated by apoptotic rate in ovarian cancer cell lines. Methods: Human epithelia ovarian cancer cell line A2780 and its platinu...
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Detection of K-ras Gene Point Mutation's Style in Human Pancreatic Cancer Cell Line PANC-1 by PCR-SSP
Objective: To detect the style of K-ras gene point mutation in human pancreatic cancer cell line PANC-1 and decide the bp sequence of Ras target position interfered by RNA. Methods: Three kinds of special sequ...
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Distinct effects of different concentrations of sodium selenite on apoptosis, cell cycle, and gene expression profile in acute promyeloytic leukemia-derived NB4 cells
Selenium at a low concentration has a chemopreventive role against cancer, while at a high concentration, it exerts a direct antitumor effect. However, the mechanisms remain elusive. In this article, we discov...
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Molecular study on differentiation-associated genes involved in both malignant progression of glioma and differentiation of human fetal neural stem cells
OBJECTIVE It is unclear whether differentiation disturbances or deregulation of neural stem cells (NSCs) are the early key steps for gliomagenesis and tumor development. Furthermore, relevant mol...
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Investigation of the effect of neoadjuvant chemotherapy on Stage II breast cancer
To investigate the effect of neoadjuvant chemotherapy in treatment of Stage II breast cancer.
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Physical and functional interaction of Runt-related protein 1 with hypoxia-inducible factor-1α
Angiogenesis and hematopoiesis are closely linked and interactive with each other, but few studies were given to identify possible links between angiogenesis-promoting proteins and hematopoiesis-related transc...
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Polymorphisms of the DNA repair gene xeroderma pigmentosum groups A and C and risk of esophageal squamous cell carcinoma in a population of high incidence region of North China
Inherited polymorphisms of DNA repair genes may contribute to variations in DNA repair capacity (DRC) and genetic susceptibility to different cancers. The aim of this study was to determine whether single nucl...
