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Article
Open AccessPhosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting
Sorting nexins anchor trafficking machines to membranes by binding phospholipids. The paradigm of the superfamily is sorting nexin 3 (SNX3), which localizes to early endosomes by recognizing phosphatidylinosit...
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Article
Open AccessHuman genome-wide RNAi screen reveals host factors required for enterovirus 71 replication
Enterovirus 71 (EV71) is a neurotropic enterovirus without antivirals or vaccine, and its host-pathogen interactions remain poorly understood. Here we use a human genome-wide RNAi screen to identify 256 host f...
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Article
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity
If the full potential of human embryonic stem (ES) cells in research and clinical applications is to be realized, we need a detailed understanding of the genetic network that governs their unique properties. A...