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Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice
The micronutrient element selenium (Se) has been shown to be effective in reducing the incidence of cancer in animal models and human clinical trials. Selenoproteins and low molecular weight Se compounds were ...
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Article
Open AccessNotch2 controls hepatocyte-derived cholangiocarcinoma formation in mice
Liver cancer comprises a group of malignant tumors, among which hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most common. ICC is especially pernicious and associated with po...
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Article
Open AccessA new mission for an old anti-cancer drug: harnessing hepatocyte-specific metabolic pathways against liver tumors