24 Result(s)
-
Article
Open AccessPartial substitution of red meat or processed meat with plant-based foods and the risk of colorectal cancer
Shifting from animal-based to plant-based diets could reduce colorectal cancer (CRC) incidence. Currently, the impacts of these dietary shifts on CRC risk are ill-defined. Therefore, we examined partial substi...
-
Article
Open AccessA prospective study of smoking-related white blood cell DNA methylation markers and risk of bladder cancer
Bladder cancer, a common neoplasm, is primarily caused by tobacco smoking. Epigenetic alterations including DNA methylation have the potential to be used as prospective markers of increased risk, particularly ...
-
Article
Open AccessSex-specific associations between sodium and potassium intake and overall and cause-specific mortality: a large prospective U.S. cohort study, systematic review, and updated meta-analysis of cohort studies
The impact of sodium intake on cardiovascular disease (CVD) health and mortality has been studied for decades, including the well-established association with blood pressure. However, non-linear patterns, dose...
-
Article
Open AccessCirculating hormones and risk of gastric cancer by subsite in three cohort studies
Obesity has been positively associated with gastric cancer. Excess fat impacts hormones, which have been implicated in carcinogenesis. We investigated obesity-related hormones and cardia gastric cancer (CGC) a...
-
Article
Correction: Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes
-
Article
Lipidomics and pancreatic cancer risk in two prospective studies
Pancreatic ductal carcinoma (PDAC) is highly fatal with limited understanding of mechanisms underlying its carcinogenesis. We comprehensively investigated whether lipidomic measures were associated with PDAC i...
-
Article
Open AccessSeparating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study
Observational studies have linked childhood obesity with elevated risk of colorectal cancer; however, it is unclear if this association is causal or independent from the effects of obesity in adulthood on colo...
-
Article
Authors’ Reply: Relationship between chocolate consumption and overall and cause-specific mortality, systematic review and updated meta-analysis
-
Article
Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes
Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtyp...
-
Article
Open AccessMetabolomic profile of prostate cancer-specific survival among 1812 Finnish men
Abnormal metabolism and perturbations in metabolic pathways play significant roles in the development and progression of prostate cancer; however, comprehensive metabolomic analyses of human data are lacking a...
-
Article
Metabolomic analysis of serum alpha-tocopherol among men in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study
The role of vitamin E in chronic disease risk remains incompletely understood, particularly in an un-supplemented state, and evidence is sparse regarding the biological actions and pathways involved in its inf...
-
Article
Relationship between chocolate consumption and overall and cause-specific mortality, systematic review and updated meta-analysis
Chocolate is a rich dietary source of various bioactive flavonoid compounds. Despite being one of the most popular foods worldwide, the association between chocolate consumption and long-term mortality remains...
-
Article
Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma
Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer (NSCLC) risk, biological mechanisms of these variants remain largely unknow...
-
Article
Open AccessAdiposity, metabolites, and colorectal cancer risk: Mendelian randomization study
Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or by sex is unclear. Further, the metabolic alterations mediating the effects of adi...
-
Article
Open AccessCirculating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses
Bilirubin, a byproduct of hemoglobin breakdown and purported anti-oxidant, is thought to be cancer preventive. We conducted complementary serological and Mendelian randomization (MR) analyses to investigate wh...
-
Article
Circulating 25-hydroxyvitamin D up to 3 decades prior to diagnosis in relation to overall and organ-specific cancer survival
While vitamin D has been associated with improved overall cancer survival in some investigations, few have prospectively evaluated organ-specific survival. We examined the accepted biomarker of vitamin D statu...
-
Article
Family history of cancer in first-degree relatives and risk of gastric cancer and its precursors in a Western population
Family history may inform risks of gastric cancer and preneoplastic lesions.
-
Article
Vitamins, metabolomics, and prostate cancer
How micronutrients might influence risk of develo** adenocarcinoma of the prostate has been the focus of a large body of research (especially regarding vitamins E, A, and D). Metabolomic profiling has the p...
-
Article
Short-term weight change and fluctuation as risk factors for type 2 diabetes in Finnish male smokers
Risk of weight change and fluctuation for type 2 diabetes was studied in a prospective study among 20,952 Finnish male smokers aged 50–69 years. Baseline data on lifestyle and medical history were collected, a...
-
Article
Open AccessFood and nutrient intake in relation to mental wellbeing
We studied food consumption and nutrient intake in subjects with depressed mood, anxiety and insomnia as indices of compromised mental wellbeing.
