137 Result(s)

Article

Plasma metabolites in childhood Burkitt lymphoma cases and cancer-free controls in Uganda

Burkitt lymphoma (BL) is an aggressive non-Hodgkin lymphoma associated with Plasmodium falciparum and Epstein-Barr virus, both of which affect metabolic pathways. The metabolomic patterns of BL is unknown.

Jiaqi Huang, Hadijah Nabalende, M. Constanza Camargo, Jacqueline Lovett… in Metabolomics (2024)

Article

Fine-map** analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unkn...

Zhishan Chen, **ngyi Guo, Ran Tao, Jeroen R. Huyghe, Philip J. Law… in Nature Communications (2024)

Article

Partial substitution of red meat or processed meat with plant-based foods and the risk of colorectal cancer

Shifting from animal-based to plant-based diets could reduce colorectal cancer (CRC) incidence. Currently, the impacts of these dietary shifts on CRC risk are ill-defined. Therefore, we examined partial substi...

Rilla Tammi, Niina E Kaartinen, Kennet Harald… in European Journal of Epidemiology (2024)

Article

A prospective study of smoking-related white blood cell DNA methylation markers and risk of bladder cancer

Bladder cancer, a common neoplasm, is primarily caused by tobacco smoking. Epigenetic alterations including DNA methylation have the potential to be used as prospective markers of increased risk, particularly ...

Roel Vermeulen, Barbara Bodinier, Sonia Dagnino… in European Journal of Epidemiology (2024)

Article

Sex-specific associations between sodium and potassium intake and overall and cause-specific mortality: a large prospective U.S. cohort study, systematic review, and updated meta-analysis of cohort studies

The impact of sodium intake on cardiovascular disease (CVD) health and mortality has been studied for decades, including the well-established association with blood pressure. However, non-linear patterns, dose...

Lu Gan, Bin Zhao, Maki Inoue-Choi, Linda M. Liao, Barry I. Graubard… in BMC Medicine (2024)

Article

Genetic influences on circulating retinol and its relationship to human health

Retinol is a fat-soluble vitamin that plays an essential role in many biological processes throughout the human lifespan. Here, we perform the largest genome-wide association study (GWAS) of retinol to date in...

William R. Reay, Dylan J. Kiltschewskij, Maria A. Di Biase… in Nature Communications (2024)

Article

Circulating hormones and risk of gastric cancer by subsite in three cohort studies

Obesity has been positively associated with gastric cancer. Excess fat impacts hormones, which have been implicated in carcinogenesis. We investigated obesity-related hormones and cardia gastric cancer (CGC) a...

Harinakshi Sanikini, Carine Biessy, Sabina Rinaldi, Anne-Sophie Navionis… in Gastric Cancer (2023)

Article

Correction: Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Sonja I. Berndt, Joseph Vijai, Yolanda Benavente, Nicola J. Camp… in Leukemia (2023)

Article

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study o...

Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, Keitaro Matsuo… in Nature Communications (2023)

Article

Partial substitution of red or processed meat with plant-based foods and the risk of type 2 diabetes

High consumption of red and processed meat has been associated with increased type 2 diabetes (T2D) risk. These kinds of diets are also environmentally unsustainable. We examined a modeled association between ...

Mirkka Maukonen, Kennet Harald, Niina E. Kaartinen, Heli Tapanainen… in Scientific Reports (2023)

Article

Serum metabolomic profile of hair dye use

The International Agency for Research on Cancer reported that some chemicals in hair dyes are probably carcinogenic to those exposed to them occupationally. Biological mechanisms through which hair dye use may...

Jung-eun Lim, Jiaqi Huang, Stephanie J. Weinstein, Dominick Parisi… in Scientific Reports (2023)

Article

Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law… in Nature Genetics (2023)

Article

Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study

Observational studies have linked childhood obesity with elevated risk of colorectal cancer; however, it is unclear if this association is causal or independent from the effects of obesity in adulthood on colo...

Nikos Papadimitriou, Caroline J. Bull, Mazda Jenab, David J. Hughes… in BMC Medicine (2023)

Article

Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score

Prostate cancer risk stratification using single-nucleotide polymorphisms (SNPs) demonstrates considerable promise in men of European, Asian, and African genetic ancestries, but there is still need for increas...

Minh-Phuong Huynh-Le, Roshan Karunamuni… in Prostate Cancer and Prostatic Diseases (2022)

Article

Interactions between folate intake and genetic predictors of gene expression levels associated with colorectal cancer risk

Observational studies have shown higher folate consumption to be associated with lower risk of colorectal cancer (CRC). Understanding whether and how genetic risk factors interact with folate could further elu...

Cameron B. Haas, Yu-Ru Su, Paneen Petersen, **aoliang Wang… in Scientific Reports (2022)