9 Result(s)
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Davide Prandi
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Open AccessRole of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes resistant and requires more potent therapies. One mechanism of resistance observed in around 10–20% of these patients i...
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Open AccessPatient derived organoids to model rare prostate cancer phenotypes
A major hurdle in the study of rare tumors is a lack of existing preclinical models. Neuroendocrine prostate cancer is an uncommon and aggressive histologic variant of prostate cancer that may arise de novo or...
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A highly specific SpCas9 variant is identified by in vivo screening in yeast
Evolved SpCas9 variant evoCas9 has improved specificity and retains near wild-type on-target activity.
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Open AccessHit and go CAS9 delivered through a lentiviral based self-limiting circuit
In vivo application of the CRISPR-Cas9 technology is still limited by unwanted Cas9 genomic cleavages. Long-term expression of Cas9 increases the number of genomic loci non-specifically cleaved by the nuclease. H...
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Open AccessErratum to: Unraveling the clonal hierarchy of somatic genomic aberrations
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Clonal evolution of chemotherapy-resistant urothelial carcinoma
Mark Rubin, Francesca Demichelis and colleagues study the evolution of urothelial carcinomas by performing whole-exome sequencing of tumors collected from patients before and after chemotherapy. They find mark...
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Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer
Genome-wide DNA methylation analysis of metastatic biopsies from patients with castration-resistant prostate cancer reveals marked epigenetic differences between samples with adenocarcinoma and neuroendocrine ...
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Open AccessASEQ: fast allele-specific studies from next-generation sequencing data
Single base level information from next-generation sequencing (NGS) allows for the quantitative assessment of biological phenomena such as mosaicism or allele-specific features in healthy and diseased cells. S...
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Open AccessUnraveling the clonal hierarchy of somatic genomic aberrations
Defining the chronology of molecular alterations may identify milestones in carcinogenesis. To unravel the temporal evolution of aberrations from clinical tumors, we developed CLONET, which upon estimation of ...
