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  1. No Access

    Article

    Genetic basis for variation in plasma IL-18 levels in persons with chronic hepatitis C virus and human immunodeficiency virus-1 infections

    Inflammasomes are multi-protein complexes integrating pathogen-triggered signaling leading to the generation of pro-inflammatory cytokines including interleukin-18 (IL-18). Hepatitis C virus (HCV) and human im...

    C Vergara, C Thio, R Latanich, A L Cox, G D Kirk, S H Mehta, M Busch… in Genes & Immunity (2017)

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    Article

    Genome-wide association study of hepatitis C virus- and cryoglobulin-related vasculitis

    The host genetic basis of mixed cryoglobulin vasculitis is not well understood and has not been studied in large cohorts. A genome-wide association study was conducted among 356 hepatitis C virus (HCV) RNA-pos...

    A L Zignego, G L Wojcik, P Cacoub, M Visentini, M Casato, A Mangia… in Genes & Immunity (2014)

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    Article

    Admixture analysis of spontaneous hepatitis C virus clearance in individuals of African descent

    Hepatitis C virus (HCV) infects an estimated 3% of the global population with the majority of individuals (75–85%) failing to clear the virus without treatment, leading to chronic liver disease. Individuals of...

    G L Wojcik, C L Thio, W H L Kao, R Latanich, J J Goedert, S H Mehta… in Genes & Immunity (2014)

  4. No Access

    Article

    Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance

    Hepatitis C virus (HCV) is an infectious blood-borne pathogen that usually persists as a chronic infection. However, approximately 15% of the time, patients can clear the virus, indicating that host difference...

    T K Oleksyk, C L Thio, A L Truelove, J J Goedert, S M Donfield… in Genes & Immunity (2005)

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    Article

    An analysis of tumor necrosis factor α gene polymorphisms and haplotypes with natural clearance of hepatitis C virus infection

    The cytokine tumor necrosis factor alpha (TNF-α) is important in generating an immune response against a hepatitis C virus (HCV) infection. The functions of TNF-α may be altered by single-nucleotide polymorphi...

    C L Thio, J J Goedert, T Mosbruger, D Vlahov, S A Strathdee… in Genes & Immunity (2004)

  6. No Access

    Article

    MICA and recovery from hepatitis C virus and hepatitis B virus infections

    The polymorphic MHC class I chain-related A (MICA) gene encodes a ligand that has different binding affinities for the NKG2D activating receptor of CD8+ T cells and natural killer (NK) cells. We hypothesized t...

    P S Karacki, X Gao, C L Thio, D L Thomas, J J Goedert, D Vlahov… in Genes & Immunity (2004)