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  1. Article

    Open Access

    Pre-operative neutrophil count and neutrophil-lymphocyte count ratio (NLCR) in predicting the histological grade of paediatric brain tumours: a preliminary study

    The neutrophil-lymphocyte count ratio (NLCR) is an established prognostic marker for renal, lung and colorectal carcinomas and has been suggested to be predictive of histological grade and outcome in adult int...

    J. R. F. Wilson, F. Saeed, A. K. Tyagi, J. R. Goodden, G. Sivakumar… in Acta Neurochirurgica (2018)

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  2. No Access

    Article

    Thinking outside the shunt—sterile CSF malabsorption in pilocytic astrocytomas: case series and review of the literature

    Ventriculoperitoneal (VP) shunt insertion is the most common cerebrospinal fluid (CSF) diversionary procedure used for the treatment of chronic hydrocephalus. Sterile CSF ascites is a rare complication of VP s...

    J. A. Johnson, P. J. O’Halloran, D. Crimmins, J. Caird in Child's Nervous System (2016)

  3. No Access

    Article

    Subtypes of oligodendroglioma defined by 1p,19q deletions, differ in the proportion of apoptotic cells but not in replication-licensed non-proliferating cells

    Oligodendrogliomas may be divided into those with deletion of chromosomes 1p and 19q (Del+), and those without (Del−). Del+ tumours show better survival and chemoresponsiveness but the reason for this differen...

    S. B. Wharton, E. Maltby, D. A. Jellinek, D. Levy, N. Atkey… in Acta Neuropathologica (2007)

  4. Article

    Open Access

    DNA replication licensing and cell cycle kinetics of oligodendroglial tumours

    The convergence point of growth-signalling pathways that control cell proliferation is the initiation of genome replication, the core of which is the assembly of pre-replicative complexes (pre-RCs), resulting ...

    S B Wharton, S Hibberd, K L Eward, D Crimmins, D A Jellinek… in British Journal of Cancer (2004)

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  5. No Access

    Article

    Detection of a novel missense mutation and second recurrent mutation in the CACNA1A gene in individuals with EA-2 and FHM

    Mutations in the brain specific P/Q type Ca2+ channel alpha1 subunit gene, CACNA1A, have been identified in three clinically distinct disorders, viz. episodic ataxia type 2 (EA-2), familial hemiplegic migraine (...

    K.L. Friend, D. Crimmins, T.G. Phan, C.M. Sue, A. Colley, V.S.C. Fung… in Human Genetics (1999)