15 Result(s)
within
Article
Chuan Yi Tang
Life Sciences
English
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Article
Open AccessClover: a clustering-oriented de novo assembler for Illumina sequences
Next-generation sequencing technologies revolutionized genomics by producing high-throughput reads at low cost, and this progress has prompted the recent development of de novo assemblers. Multiple assembly me...
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Application of 16S rRNA metagenomics to analyze bacterial communities at a respiratory care centre in Taiwan
In this study, we applied a 16S ribosomal RNA (rRNA) metagenomics approach to survey inanimate hospital environments (IHEs) in a respiratory care center (RCC). A total of 16 samples, including 9 from medical d...
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Open AccessTranscriptome profiling in imipenem-selected Acinetobacter baumannii
Carbapenem-resistance in Acinetobacter baumannii has gradually become a global challenge. To identify the genes involved in carbapenem resistance in A. baumannii, the transcriptomic responses of the completely se...
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Open AccessThe chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi’s sarcoma associated herpesvirus reactivation
SUMOylation, as part of the epigenetic regulation of transcription, has been intensively studied in lower eukaryotes that contain only a single SUMO protein; however, the functions of SUMOylation during mammal...
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Open AccessReconstruction of phyletic trees by global alignment of multiple metabolic networks
In the last decade, a considerable amount of research has been devoted to investigating the phylogenetic properties of organisms from a systems-level perspective. Most studies have focused on the classificatio...
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Open AccessWhole-genome sequencing and identification of Morganella morganii KT pathogenicity-related genes
The opportunistic enterobacterium, Morganella morganii, which can cause bacteraemia, is the ninth most prevalent cause of clinical infections in patients at Changhua Christian Hospital, Taiwan. The KT strain of M...
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Open AccessAn efficient RNA interference screening strategy for gene functional analysis
RNA interference (RNAi) is commonly applied in genome-scale gene functional screens. However, a one-on-one RNAi analysis that targets each gene is cost-ineffective and laborious. Previous studies have indicate...
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Open AccessMetabolic classification of microbial genomes using functional probes
Microorganisms able to grow under artificial culture conditions comprise only a small proportion of the biosphere's total microbial community. Until recently, scientists have been unable to perform thorough an...
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Open AccessA novel method to identify cooperative functional modules: study of module coordination in the Saccharomyces cerevisiae cell cycle
Identifying key components in biological processes and their associations is critical for deciphering cellular functions. Recently, numerous gene expression and molecular interaction experiments have been repo...
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Open AccessA genetic algorithm-based boolean delay model of intracellular signal transduction in inflammation
Signal transduction is the major mechanism through which cells transmit external stimuli to evoke intracellular biochemical responses. Understanding relationship between external stimuli and corresponding cell...
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Open AccessFeature amplified voting algorithm for functional analysis of protein superfamily
Identifying the regions associated with protein function is a singularly important task in the post-genomic era. Biological studies often identify functional enzyme residues by amino acid sequences, particular...
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Open AccessComputational modeling with forward and reverse engineering links signaling network and genomic regulatory responses: NF-κB signaling-induced gene expression responses in inflammation
Signal transduction is the major mechanism through which cells transmit external stimuli to evoke intracellular biochemical responses. Diverse cellular stimuli create a wide variety of transcription factor act...
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Open AccessA parallel and incremental algorithm for efficient unique signature discovery on DNA databases
DNA signatures are distinct short nucleotide sequences that provide valuable information that is used for various purposes, such as the design of Polymerase Chain Reaction primers and microarray experiments. B...
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Open AccessTranscriptional regulation of human eosinophil RNases by an evolutionary- conserved sequence motif in primate genome
Human eosinophil-derived neurotoxin (edn) and eosinophil cationic protein (ecp) are members of a subfamily of primate ribonuclease (rnase) genes. Although they are generated by gene duplication event, distinct ed...
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Open AccessA reinforced merging methodology for map** unique peptide motifs in members of protein families
Members of a protein family often have highly conserved sequences; most of these sequences carry identical biological functions and possess similar three-dimensional (3-D) structures. However, enzymes with hig...
