519 Result(s)
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Chen**g Zhu
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Open AccessGerm granule compartments coordinate specialized small RNA production
Germ granules are biomolecular condensates present in most animal germ cells. One function of germ granules is to help maintain germ cell totipotency by organizing mRNA regulatory machinery, including small RN...
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Open AccessEndothelial cells-derived exosomes-based hydrogel improved tendinous repair via anti-inflammatory and tissue regeneration-promoting properties
Tendon injuries are common orthopedic ailments with a challenging healing trajectory, especially in cases like the Achilles tendon afflictions. The healing trajectory of tendon injuries is often suboptimal, le...
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Open AccessCaspase-3 promotes oncogene-induced malignant transformation via EndoG-dependent Src-STAT3 phosphorylation
Accumulating evidence suggests that caspase-3 plays critical roles beyond apoptosis, serving pro-survival functions in malignant transformation and tumorigenesis. However, the mechanism of non-apoptotic action...
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Open AccessA semantic feature enhanced YOLOv5-based network for polyp detection from colonoscopy images
Colorectal cancer (CRC) is a common digestive system tumor with high morbidity and mortality worldwide. At present, the use of computer-assisted colonoscopy technology to detect polyps is relatively mature, bu...
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Open AccessConsensus credit ratings: a view from banks
While the production of credit ratings has long been limited mainly to rating agencies (CRAs), recent years have seen the growing popularity of consensus credit ratings crowdsourced from banks (i.e., bank rati...
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Open AccessVertiport navigation requirements and multisensor architecture considerations for urban air mobility
Communication, Navigation and Surveillance (CNS) technologies are key enablers for future safe operation of drones in urban environments. However, the design of navigation technologies for these new applicatio...
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Open AccessNBS1 lactylation is required for efficient DNA repair and chemotherapy resistance
The Warburg effect is a hallmark of cancer that refers to the preference of cancer cells to metabolize glucose anaerobically rather than aerobically1,2. This results in substantial accumulation of lacate, the end...
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Open AccessCrosstalk among proximal tubular cells, macrophages, and fibroblasts in acute kidney injury: single-cell profiling from the perspective of ferroptosis
The link between ferroptosis, a form of cell death mediated by iron and acute kidney injury (AKI) is recently gaining widespread attention. However, the mechanism of the crosstalk between cells in the pathogen...
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Open AccessGadolinium-enhanced intracranial aneurysm wall imaging and risk of aneurysm growth and rupture: a multicentre longitudinal cohort study
In patients with an unruptured intracranial aneurysm, gadolinium enhancement of the aneurysm wall is associated with growth and rupture. However, most previous studies did not have a longitudinal design and di...
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Open AccessRational construction of a high-quality and high-efficiency biosynthetic system and fermentation optimization for A82846B based on combinatorial strategies in Amycolatopsis orientalis
Oritavancin is a new generation of semi-synthetic glycopeptide antibiotics against Gram-positive bacteria, which served as the first and only antibiotic with a single-dose therapeutic regimen to treat ABSSSI. ...
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Open AccessRadiographic evaluation of robot-assisted versus manual total hip arthroplasty: a multicenter randomized controlled trial
The effectiveness of robot-assisted surgery remains contentious due to the lack of high-quality randomized controlled trials (RCTs) to elevate the level of evidence. We aimed to evaluate the postoperative radi...
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Open AccessArbuscular mycorrhizal fungi by inducing watermelon roots secretion phthalates, altering soil enzyme activity and bacterial community composition to alleviate the watermelon wilt
Long-term continuous crop** has resulted in the frequent occurrence of fusarium wilt of watermelon (Citrullus lanatus). AMF inoculation can alleviate the continuous crop** barrier and reduce the incidence of ...
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Open AccessA chromosome-level genome of the striated frogfish (Antennarius striatus)
The striated frogfish (Antennarius striatus), a member of the sub-order Antennarioidei within the order Lophiiformes, possesses remarkable adaptations. These include the ability to modulate body coloration for ca...
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Open AccessRANKL/RANK signaling recruits Tregs via the CCL20–CCR6 pathway and promotes stemness and metastasis in colorectal cancer
TNF receptor superfamily member 11a (TNFRSF11a, RANK) and its ligand TNF superfamily member 11 (TNFRSF11, RANKL) are overexpressed in many malignancies. However, the clinical importance of RANKL/RANK in colore...
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Open AccessTMC6 functions as a GPCR-like receptor to sense noxious heat via Gαq signaling
Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism is not fully understood yet. Here, we find that TMC6, a membrane protein of unknown function, is highly ...
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Correction: Roles of estrogen receptors during sexual reversal in pelodiscus sinensis
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Open AccessImproved predictions of total kidney volume growth rate in ADPKD using two-parameter least squares fitting
Mayo Imaging Classification (MIC) for predicting future kidney growth in autosomal dominant polycystic kidney disease (ADPKD) patients is calculated from a single MRI/CT scan assuming exponential kidney volume...
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Open AccessAnalysis of the biocorrosion community from ancient wooden constructions at Tianluoshan (7000–6300 cal BP), Zhejiang Province, China
Ancient wooden constructions, also known as wooden cultural relics, refers to ancient wood that has been modified or crafted by human activities. To ensure its preservation, it is crucial to gain further under...
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Open AccessChanges of aqueous humor cytokine profiles of patients with high intraocular pressure after PPV for retinal detachment
High intraocular pressure (IOP) is one of the early complications after pars plana vitrectomy (PPV), which may cause glaucoma and poor visual prognosis secondary to surgery. Proliferative vitreoretinopathy (PV...
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Open AccessGut microbiota and metabolites signatures of clinical response in anti-PD-1/PD-L1 based immunotherapy of biliary tract cancer
Accumulating evidence suggests that the gut microbiota and metabolites can modulate tumor responses to immunotherapy; however, limited data has been reported on biliary tract cancer (BTC). This study used meta...
