42 Result(s)

Article

Mitosis and microtubule organizational changes in rice root-tip cells

The pattern of change of the microtubule cytoskeleton of the root-tip cells of rice during mitosis was studied using immunofluorescence technic and confocal laser scanning microscopy. All the major stages of c...

Shixiong Xu, Chungui Li, Cheng Zhu in Cell Research (1993)

Article

Engineering a zinc binding site into the de novo designed protein DS119 with a βαβ structure

Functional proteins designed de novo have potential application in chemical engineering, agriculture and healthcare. Metal binding sites are commonly used to incorporate functions. Based on a de novo designed pro...

Cheng Zhu, Changsheng Zhang, Huanhuan Liang, Luhua Lai in Protein & Cell (2011)

Article

Epigallocatechin-3-gallate enhances ER stress-induced cancer cell apoptosis by directly targeting PARP16 activity

Poly(ADP-ribose) polymerases (PARPs) are ADP-ribosylating enzymes and play important roles in a variety of cellular processes. Most small-molecule PARP inhibitors developed to date have been against PARP1, a p...

Juanjuan Wang, Chenggang Zhu, Dan Song, Ruiqi **a, Wenbo Yu… in Cell Death Discovery (2017)

Article

miR-181a-5p suppresses invasion and migration of HTR-8/SVneo cells by directly targeting IGF2BP2

Pre-eclampsia is a pregnancy-related disease that may cause maternal, neonatal and fetal morbidity and mortality and exists in 3–5% of pregnancies worldwide. The discovery of dysregulated microRNAs and their r...

Liang Wu, Wen-yan Song, Ya **e, Lin-li Hu, **ao-man Hou, Rui Wang… in Cell Death & Disease (2018)

Article

Exosomal lncRNA 91H is associated with poor development in colorectal cancer by modifying HNRNPK expression

Exosomes mediated transfer of lncRNA 91H may play a critical role in the development of CRC. However, few studies have proved the mechanism. So we performed this study to deeply explore the biological function...

Tianyi Gao, **angxiang Liu, Bangshun He, Zhenlin Nie… in Cancer Cell International (2018)

Article

Endogenous authentic OCT4A proteins directly regulate FOS/AP-1 transcription in somatic cancer cells

OCT4A is well established as a master transcription factor for pluripotent stem cell (PSC) self-renewal and a pioneer factor for initiating somatic cell reprogramming, yet its presence and functionality in som...

Yanwen Zhou, **nyu Chen, Bo Kang, Shiqi She, **aobing Zhang… in Cell Death & Disease (2018)

Article

Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta 

The placenta is crucial for a successful pregnancy and the health of both the fetus and the pregnant woman. However, how the human trophoblast lineage is regulated, including the categorization of the placenta...

Yawei Liu, **aoying Fan, Rui Wang, **aoyin Lu, Yan-Li Dang, Huiying Wang… in Cell Research (2018)

Article

MicroRNA-524 promotes cell proliferation by down-regulating PTEN expression in osteosarcoma

Increasing numbers of studies have examined the correlation between specific miRNAs and tumours to enable their diagnosis and treatment. However, there are few reports regarding the concrete role and mechanism...

Ming Zhuang, Xubin Qiu, Dong Cheng, Chenlei Zhu, Liang Chen in Cancer Cell International (2018)

Article

M3 muscarinic acetylcholine receptors regulate epithelial–mesenchymal transition, perineural invasion, and migration/metastasis in cholangiocarcinoma through the AKT pathway

Cholangiocarcinoma is a highly malignant tumor type that is not sensitive to radiotherapy or chemotherapy due to aggressive perineural invasion and metastasis. Unfortunately, the mechanisms underlying these pr...

Yujie Feng, **ao Hu, Guangwei Liu, Lianfang Lu, Wei Zhao… in Cancer Cell International (2018)

Article

The yin and yang functions of extracellular ATP and adenosine in tumor immunity

Extracellular adenosine triphosphate (eATP) and its main metabolite adenosine (ADO) constitute an intrinsic part of immunological network in tumor immunity. The concentrations of eATP and ADO in tumor microenv...

Li-li Feng, Yi-qing Cai, Ming-chen Zhu, Li-jie **ng, **n Wang in Cancer Cell International (2020)

Article

Baicalein inhibits SARS-CoV-2/VSV replication with interfering mitochondrial oxidative phosphorylation in a mPTP dependent manner

Shichao Huang, Yu’e Liu, Yanan Zhang, Ru Zhang… in Signal Transduction and Targeted Therapy (2020)

Article

Decrease of peripheral blood mucosal‐associated invariant T cells and impaired serum Granzyme-B production in patients with gastric cancer

Mucosal-associated invariant T (MAIT) cells are an invariant T cell subset, which have been reported to play an antimicrobial role in infectious diseases. However, little is known about it in malignant disease...

Chunyan Shao, Chenwen Zhu, Yun Zhu, Jiqing Hao, Yongxiang Li… in Cell & Bioscience (2021)

Article

Identification of glycolysis related pathways in pancreatic adenocarcinoma and liver hepatocellular carcinoma based on TCGA and GEO datasets

Abnormal energy metabolism is one of the characteristics of tumor cells, and it is also a research hotspot in recent years. Due to the complexity of digestive system structure, the frequency of tumor is relati...

Ji Li, Chen Zhu, Peipei Yue, Tianyu Zheng, Yan Li, Biao Wang… in Cancer Cell International (2021)

Article

RANK promotes colorectal cancer migration and invasion by activating the Ca²⁺-calcineurin/NFATC1-ACP5 axis

The tumor necrosis factor (TNF) receptor superfamily member 11a (TNFRSF11a, also known as RANK) was demonstrated to play an important role in tumor metastasis. However, the specific function of RANK in colorec...

Qian Liang, Yun Wang, Yingsi Lu, Qingqing Zhu, … in Cell Death & Disease (2021)

Article

HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19

Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a major pathological feature of Coronavirus Disease 2019 (COVID-19) and a crucial determinant in COVID-19 prognosis. Un...

Mingfu Tian, Weiyong Liu, **ang Li, Peiyi Zhao… in Signal Transduction and Targeted Therapy (2021)

Article

Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis

Molecular mechanisms underlying breast cancer lymph node metastasis remain unclear. Using single-cell sequencing, we investigated the transcriptome profile of 96,796 single cells from 15 paired samples of prim...

Kun Xu, Runtian Wang, Hui **e, Longfei Hu, Cong Wang, Jiali Xu, Chengjun Zhu… in Oncogenesis (2021)

Article

Chorionic villus-derived mesenchymal stem cell-mediated autophagy promotes the proliferation and invasiveness of trophoblasts under hypoxia by activating the JAK2/STAT3 signalling pathway

Trophoblast dysfunction during pregnancy is fundamentally involved in preeclampsia. Several studies have revealed that human chorionic villous mesenchymal stem cells (CV-MSCs) could regulate trophoblasts funct...

Yi**g Chu, Chengzhan Zhu, Chongyu Yue, Wei Peng, Wei** Chen… in Cell & Bioscience (2021)

Article

High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors

A new coronavirus (SARS-CoV-2) has been identified as the etiologic agent for the COVID-19 outbreak. Currently, effective treatment options remain very limited for this disease; therefore, there is an urgent n...

Yao Zhao, **aoyu Du, Yinkai Duan, **aoyan Pan, Yifang Sun, Tian You… in Protein & Cell (2021)

Article

Aberrantly expressed Wnt5a in nurse-like cells drives resistance to Venetoclax in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of neoplastic B lymphocytes with high levels of Wnt5a in the plasma. Currently, the cell source of Wnt5a remains controversial. The recep...

Yao Guo, Hanzhong Pei, Bo Lu, Dengyang Zhang, Yuming Zhao, Fuqun Wu… in Cell Death Discovery (2022)

Article

miR-30a targets STOX2 to increase cell proliferation and metastasis in hydatidiform moles via ERK, AKT, and P38 signaling pathways

A hydatidiform mole is a condition caused by abnormal proliferation of trophoblastic cells. MicroRNA miR-30a acts as a tumor suppressor gene in most tumors and participates in the development of various cancer...

Zhenzhen Guo, Chenyu Zhu, Youhui Wang, Zhen Li, Lu Wang… in Cancer Cell International (2022)