59 Result(s)

Article

Using support vector classification for SAR of fentanyl derivatives

To discriminate between fentanyl derivatives with high and low activities.

Ning Dong, Wen-cong Lu, Nian-yi Chen, You-cheng Zhu… in Acta Pharmacologica Sinica (2005)

Article

Effects of spider Macrothele raven venom on cell proliferation and cytotoxicity in HeLa cells

To examine the effect of venom from the spider Macrothele raven on cell proliferation and cytotoxicity in human cervical carcinoma, HeLa cells.

Li Gao, Bao-en Shan, **g Chen, Jiang-hui Liu, Da-xiang Song… in Acta Pharmacologica Sinica (2005)

Article

Induction of B-cell lymphoma by UVB Radiation in p53 Haploinsufficient Mice

The incidence of non-Hodgkin's lymphoma has increased over recent years. The exact etiology of lymphoma remains unknown. Ultraviolet light exposure has been associated with the development of internal lymphoid...

Nahum Puebla-Osorio, Yasuko Miyahara, Sreevidya Coimbatore… in BMC Cancer (2011)

Article

Polymorphisms of the prion protein gene and their effects on litter size and risk evaluation for scrapie in Chinese Hu sheep

It is well known that scrapie is a fatal, neurodegenerative disease in sheep and goat, which belongs to the group of transmissible spongiform encephalopathies (TSEs) or prion diseases. It has been confirmed th...

Feng Guan, Lei Pan, Jie Li, Hong Tang, Cheng Zhu, Guoqing Shi in Virus Genes (2011)

Article

α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation

Although evidence suggests that the prevalence of Parkinson’s disease (PD) is lower in smokers than in non-smokers, the mechanisms of nicotine-induced neuroprotection remain unclear. Stimulation of the α7 nico...

Yuan Liu, Jun Hu, Jie Wu, Chenlei Zhu, Yujian Hui… in Journal of Neuroinflammation (2012)

Article

Correction: Corrigendum: Aiolos promotes T_H17 differentiation by directly silencing Il2 expression

Nat. Immunol. 13, 770–777 (2012); published online 1 July 2012; corrected after print 21 September 2012 In the version of this article initially published, some data in the bottom right plot in Figure 3d were ...

Francisco J Quintana, Hulin **, Evan J Burns, Meghan Nadeau… in Nature Immunology (2014)

Article

Linalool, derived from Cinnamomum camphora (L.) Presl leaf extracts, possesses molluscicidal activity against Oncomelania hupensis and inhibits infection of Schistosoma japonicum

Schistosomiasis japonicum remains a considerable economic and public health concern in China, the Philippines and Indonesia. Currently available measures to control the unique intermediate host Oncomelania hupens...

Fan Yang, Er** Long, Juhua Wen, Lei Cao, Chengcheng Zhu… in Parasites & Vectors (2014)

Article

Associations of UDP-glucuronosyltransferases polymorphisms with mycophenolate mofetil pharmacokinetics in Chinese renal transplant patients

To evaluate the effects of UDP-glucuronosyltransferases (UGTs) polymorphisms on the pharmacokinetics of the immunosuppressant mycophenolate mofetil (MMF) in Chinese renal transplant recipients.

**ao-chun **e, Jun Li, Hong-yang Wang, Hong-liang Li… in Acta Pharmacologica Sinica (2015)

Article

Noise trauma and systemic application of the selective glucocorticoid receptor modulator compound A

Selective glucocorticoid receptor modulators (SEGRMs) comprise a novel class of drugs promising both reduced side effects and similar pharmacological potency relative to glucocorticoids, which presently serve ...

Lukas D. Landegger, Clemens Honeder… in Journal of Negative Results in BioMedicine (2016)

Article

Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells

Hsp90 proteins are important therapeutic targets for many anti-cancer drugs in clinical trials. Geldanamycin (GA) was identified as the first natural inhibitor of Hsp90, increasing evidence suggests that GA wa...

Zhirui Zhang, Hong-Mei Li, Can Zhou… in Journal of Experimental & Clinical Cancer … (2016)

Article

Capilliposide from Lysimachia capillipes inhibits AKT activation and restores gefitinib sensitivity in human non-small cell lung cancer cells with acquired gefitinib resistance

Most gefitinib-treated patients with non-small cell lung cancer (NSCLC) would eventually develop resistance. Lysimachia capillipes (LC) capilliposide extracts from LC Hemsl. show both in vitro and in vivo anti-ca...

Shi-rong Zhang, Ya-si Xu, Er **, Lu-cheng Zhu, Bing **a… in Acta Pharmacologica Sinica (2017)

Article

Immunotherapy Bridge 2016 and Melanoma Bridge 2016: meeting abstracts

Vera Hirsh, Sandro Pignata, Melissa Bersanelli… in Journal of Translational Medicine (2017)

Article

Activity of temocillin and 15 other agents, including fosfomycin and colistin, against Enterobacteriaceae in Hong Kong

Limited data are available on temocillin susceptibilities in Enterobacteriaceae from Asian countries where antimicrobial resistance is prevalent. The in vitro activities of temocillin and 15 commonly used antimic...

Margaret Ip, Christopher K. Lai… in European Journal of Clinical Microbiology … (2017)

Article

Immunotherapy Bridge 2017 and Melanoma Bridge 2017: meeting abstracts

David Carbone, Michael Sharpnack, Kai He… in Journal of Translational Medicine (2018)

Article

Exosomal lncRNA 91H is associated with poor development in colorectal cancer by modifying HNRNPK expression

Exosomes mediated transfer of lncRNA 91H may play a critical role in the development of CRC. However, few studies have proved the mechanism. So we performed this study to deeply explore the biological function...

Tianyi Gao, **angxiang Liu, Bangshun He, Zhenlin Nie… in Cancer Cell International (2018)

Article

Taxonomy of the family Arenaviridae and the order Bunyavirales: update 2018

In 2018, the family Arenaviridae was expanded by inclusion of 1 new genus and 5 novel species. At the same time, the recently established order Bunyavirales was expanded by 3 species. This article presents the up...

Piet Maes, Sergey V. Alkhovsky, Yīmíng Bào, Martin Beer… in Archives of Virology (2018)

Article

MicroRNA-524 promotes cell proliferation by down-regulating PTEN expression in osteosarcoma

Increasing numbers of studies have examined the correlation between specific miRNAs and tumours to enable their diagnosis and treatment. However, there are few reports regarding the concrete role and mechanism...

Ming Zhuang, Xubin Qiu, Dong Cheng, Chenlei Zhu, Liang Chen in Cancer Cell International (2018)

Article

M3 muscarinic acetylcholine receptors regulate epithelial–mesenchymal transition, perineural invasion, and migration/metastasis in cholangiocarcinoma through the AKT pathway

Cholangiocarcinoma is a highly malignant tumor type that is not sensitive to radiotherapy or chemotherapy due to aggressive perineural invasion and metastasis. Unfortunately, the mechanisms underlying these pr...

Yujie Feng, **ao Hu, Guangwei Liu, Lianfang Lu, Wei Zhao… in Cancer Cell International (2018)

Article

Prevalence and relationship of malnutrition and distress in patients with Cancer using questionnaires

Negative feelings, such as anxiety and depression, are common in patients with cancer. Our aim was to investigate the prevalence of malnutrition and distress in cancer patients and to examine the relationship ...

Chen**g Zhu, Baoqing Wang, Yuan Gao, Xuelei Ma in BMC Cancer (2018)

Article

Effectiveness of two different dose administration regimens of an IL-15 superagonist complex (ALT-803) in an orthotopic bladder cancer mouse model

We set out to determine if the administration of subcutaneous (SQ) ALT-803 was non-inferior to standard intravesical BCG treatment in a carcinogen induced mouse (C57BL/6J) bladder cancer model.

Hideki Furuya, Owen T. M. Chan, Ian Pagano… in Journal of Translational Medicine (2019)