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  1. Article

    Using support vector classification for SAR of fentanyl derivatives

    To discriminate between fentanyl derivatives with high and low activities.

    Ning Dong, Wen-cong Lu, Nian-yi Chen, You-cheng Zhu in Acta Pharmacologica Sinica (2005)

  2. Article

    Effects of spider Macrothele raven venom on cell proliferation and cytotoxicity in HeLa cells

    To examine the effect of venom from the spider Macrothele raven on cell proliferation and cytotoxicity in human cervical carcinoma, HeLa cells.

    Li Gao, Bao-en Shan, **g Chen, Jiang-hui Liu, Da-xiang Song in Acta Pharmacologica Sinica (2005)

  3. No Access

    Article

    Aerosolized STAT1 Antisense Oligodeoxynucleotides Decrease the Concentrations of Inflammatory Mediators in Bronchoalveolar Lavage Fluid in Bleomycin-Induced Rat Pulmonary Fibrosis

    It has been demonstrated that alveolar macrophages (AMs) play a key role in the pathogenesis of pulmonary fibrosis by releasing a variety of cytokines and inflammatory mediators. In addition, abnormal signal t...

    Ming Zeng, Bin Liao, Chen Zhu, Wenjun Wang, **aoqin Zhan in Cellular & Molecular Immunology (2008)

  4. No Access

    Article

    The Effects of Aerosolized STAT1 Antisense Oligodeoxynucleotides on Rat Pulmonary Fibrosis

    Previous study showed that aerosolized signal transducer and activator of transcription-1 (STAT1) antisense oligodeoxynucleotide (ASON) inhibited the expression of STAT1 and ICAM-1 mRNA and protein in alveolar...

    Wenjun Wang, Bin Liao, Ming Zeng, Chen Zhu, **anming Fan in Cellular & Molecular Immunology (2009)

  5. No Access

    Article

    Molecular cloning and characterization of a cathepsin B from Angiostrongylus cantonensis

    Cysteine proteases, a superfamily of hydrolytic enzymes, have numerous functions in parasites. Here, we reported the cloning and characterization of a cDNA encoding a cathepsin B (AcCPB) from Angiostrongylus cant...

    Yan-** Han, Zheng-yu Li, Bao-chuan Li, ** Sun, Cheng-cheng Zhu in Parasitology Research (2011)

  6. Article

    Open Access

    Polymorphisms of the prion protein gene and their effects on litter size and risk evaluation for scrapie in Chinese Hu sheep

    It is well known that scrapie is a fatal, neurodegenerative disease in sheep and goat, which belongs to the group of transmissible spongiform encephalopathies (TSEs) or prion diseases. It has been confirmed th...

    Feng Guan, Lei Pan, Jie Li, Hong Tang, Cheng Zhu, Guoqing Shi in Virus Genes (2011)

  7. No Access

    Article

    AcCystatin, an immunoregulatory molecule from Angiostrongylus cantonensis, ameliorates the asthmatic response in an aluminium hydroxide/ovalbumin-induced rat model of asthma

    Epidemiological surveys have demonstrated that helminth infections are negatively related to atopic diseases, including asthma. Defining and characterising specific helminth molecules that have excellent immun...

    Pengyu Ji, Huiling Hu, **angyun Yang, **aoxia Wei, Chengcheng Zhu in Parasitology Research (2015)

  8. Article

    Associations of UDP-glucuronosyltransferases polymorphisms with mycophenolate mofetil pharmacokinetics in Chinese renal transplant patients

    To evaluate the effects of UDP-glucuronosyltransferases (UGTs) polymorphisms on the pharmacokinetics of the immunosuppressant mycophenolate mofetil (MMF) in Chinese renal transplant recipients.

    **ao-chun **e, Jun Li, Hong-yang Wang, Hong-liang Li in Acta Pharmacologica Sinica (2015)

  9. Article

    Capilliposide from Lysimachia capillipes inhibits AKT activation and restores gefitinib sensitivity in human non-small cell lung cancer cells with acquired gefitinib resistance

    Most gefitinib-treated patients with non-small cell lung cancer (NSCLC) would eventually develop resistance. Lysimachia capillipes (LC) capilliposide extracts from LC Hemsl. show both in vitro and in vivo anti-ca...

    Shi-rong Zhang, Ya-si Xu, Er **, Lu-cheng Zhu, Bing **a in Acta Pharmacologica Sinica (2017)

  10. Article

    Open Access

    Activity of temocillin and 15 other agents, including fosfomycin and colistin, against Enterobacteriaceae in Hong Kong

    Limited data are available on temocillin susceptibilities in Enterobacteriaceae from Asian countries where antimicrobial resistance is prevalent. The in vitro activities of temocillin and 15 commonly used antimic...

    Margaret Ip, Christopher K. Lai in European Journal of Clinical Microbiology … (2017)

  11. Article

    Taxonomy of the family Arenaviridae and the order Bunyavirales: update 2018

    In 2018, the family Arenaviridae was expanded by inclusion of 1 new genus and 5 novel species. At the same time, the recently established order Bunyavirales was expanded by 3 species. This article presents the up...

    Piet Maes, Sergey V. Alkhovsky, Yīmíng Bào, Martin Beer in Archives of Virology (2018)

  12. No Access

    Article

    Endothelial cell-specific anticoagulation reduces inflammation in a mouse model of acute lung injury

    Tissue factor (TF)-dependent coagulation contributes to lung inflammation and the pathogenesis of acute lung injury (ALI). In this study, we explored the roles of targeted endothelial anticoagulation in ALI us...

    Jian Lou, Yue Hu, Min-dan Wu, Luan-qing Che, Yin-fang Wu in Acta Pharmacologica Sinica (2019)

  13. Article

    Open Access

    Dysbiosis of urine microbiota in obstructive urinary retention patients revealed by next-generation sequencing

    Urinary retention (UR) is a common urinary system disease can be caused by urinary tract obstruction with numerous reasons, however, the role of urine microbes in these disorders is still poorly understood. Th...

    Shan Jiang, Saisai Lu, **aomin Chen in Annals of Clinical Microbiology and Antimi… (2021)

  14. Article

    Open Access

    Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson’s disease

    Parkinson’s disease (PD) is a neurodegenerative disorder with no absolute cure. The evidence of the involvement of gut microbiota in PD pathogenesis suggests the need to identify certain molecule(s) derived fr...

    Yan-fang Hou, Chang Shan, Si-yue Zhuang, Qian-qian Zhuang, Arijit Ghosh in Microbiome (2021)

  15. No Access

    Article

    Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (RORγt) modulators: insights into different protein behaviors with “short” and “long” inverse agonists

    A series of 6-substituted carbazole-based retinoic acid-related orphan receptor gamma-t (RORγt) modulators were discovered through 6-position modification guided by insights from the crystallographic profiles ...

    Ming-cheng Yu, Feng Yang, **ao-yu Ding, Nan-nan Sun in Acta Pharmacologica Sinica (2021)

  16. Article

    Open Access

    Current Status of Human Papillomavirus-Related Head and Neck Cancer: From Viral Genome to Patient Care

    Human papillomavirus (HPV) infection identified as a definitive human carcinogen is increasingly being recognized for its role in carcinogenesis of human cancers. Up to 38%–80% of head and neck squamous cell c...

    Haoru Dong, **nhua Shu, Qiang Xu, Chen Zhu, Andreas M. Kaufmann in Virologica Sinica (2021)

  17. Article

    Open Access

    Heritability of tomato rhizobacteria resistant to Ralstonia solanacearum

    Ralstonia solanacearum (Rs) is a soilborne phytopathogen that causes bacterial wilt and substantial yield losses in many plants, such as tomatoes. A resistant tomato cultivar can recruit a beneficial microbiome f...

    Jiakang Yin, Ziliang Zhang, Chengcheng Zhu, Taotao Wang, Ruihong Wang in Microbiome (2022)

  18. No Access

    Article

    Construction of a Cuproptosis-Related Gene Signature for Predicting Prognosis in Gastric Cancer

    This study aimed to develop and validate a cuproptosis-related gene signature for the prognosis of gastric cancer. The data in TCGA GC TPM format from UCSC were extracted for analysis, and GC samples were rand...

    Yongli Hu, Yan Du, Zhisheng Qiu, Pengwei Bai, Zhaozhao Bai in Biochemical Genetics (2024)