-
Article
Publisher Correction: The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells
-
Article
The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells
Natural killer (NK) cells kill infected, transformed and stressed cells when an activating NK cell receptor is triggered1. Most NK cells and some innate lymphoid cells express the activating receptor NKp46, encod...
-
Article
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
SARS-CoV-2 can cause acute respiratory distress and death in some patients1. Although severe COVID-19 is linked to substantial inflammation, how SARS-CoV-2 triggers inflammation is not clear2. Monocytes and macro...
-
Article
Inflammasome activation in infected macrophages drives COVID-19 pathology
Severe COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine production, viral RNA and a sustained interferon (IFN) response, all of which are recapitulated and required for patholog...
-
Article
Open AccessAuthor Correction: Caspase-8 mediates inflammation and disease in rodent malaria
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Open AccessCaspase-8 mediates inflammation and disease in rodent malaria
Earlier studies indicate that either the canonical or non-canonical pathways of inflammasome activation have a limited role on malaria pathogenesis. Here, we report that caspase-8 is a central mediator of syst...
-
Article
Gasdermin E suppresses tumour growth by activating anti-tumour immunity
Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)1. Gasdermin E (GSDME, also known as DFNA5)—mutated in familial ageing-related hearin...