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Article
AChE uses
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Article
A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10
Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominantly inherited cancer syndrome characterized by medullary carcinoma of the thyroid, phaeochromocytoma and hyperparathyroidism. Almost all gen...
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Article
Deletion of genes on chromosome 1 in endocrine neoplasia
Recent studies have identified normal cellular DNA sequences which are lost in the development of embryonal1–6 and adult7,8 tumours. These tumours are thought to arise after a primary mutation in one allele of s...
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Article
Paternal origin of new mutations in Von Recklinghausen neurofibromatosis
VON Recklinghausen neurofibromatosis (NF-1)1–4 is a common autosomal dominant disorder. The estimated new mutation rate (1 x 10−4) is one of the highest for a human disorder1. Here we report that in 12 of 14 fam...