28 Result(s)

Article

Evaluation of Psychological Wellbeing and Social Impact of Combined Facial and Truncal Acne: a Multi-national, Mixed-Methods Study

Half of the individuals with facial acne develop truncal acne, but the impact of combined facial and truncal acne (CA) on patients’ quality of life is poorly researched.

Jerry Tan, Stefan Beissert, Fran Cook-Bolden, Rajeev Chavda… in Dermatology and Therapy (2022)

Article

Advocacy for a shared physician/patient approach for the management of acne, rosacea, seborrheic dermatitis and photodamage

Brigitte Dréno, Richard L. Gallo, Enzo Berardesca… in European Journal of Dermatology (2022)

Article

Impact of Facial Atrophic Acne Scars on Quality of Life: A Multi-country Population-Based Survey

Acne affects more than 80% of adolescents and young adults, who most often develop acne scars. Supporting data on the effect of acne scars on patient’s health-related quality of life (HRQOL) are limited.

Jerry Tan, Stefan Beissert, Fran Cook-Bolden… in American Journal of Clinical Dermatology (2022)

Article

Key Clinical Adverse Events in Patients with Advanced Basal Cell Carcinoma Treated with Sonidegib or Vismodegib: A Post Hoc Analysis

Sonidegib is approved to treat locally advanced basal cell carcinoma (laBCC) in the USA, EU, Switzerland, and Australia and metastatic basal cell carcinoma (mBCC) in Switzerland and Australia in patients not a...

Ralf Gutzmer, Carmen Loquai, Caroline Robert, Brigitte Dréno… in Dermatology and Therapy (2021)

Article

Phase I/II clinical trial of adoptive cell transfer of sorted specific T cells for metastatic melanoma patients

Adoptive cell transfer (ACT) of tumor-specific T lymphocytes represents a relevant therapeutic strategy to treat metastatic melanoma patients. Ideal T-cells should combine tumor specificity and reactivity with...

Brigitte Dréno, Amir Khammari, Agnès Fortun… in Cancer Immunology, Immunotherapy (2021)

Article

Acne Scarring: Why We Should Act Sooner Rather Than Later

Brigitte Dréno, Linda Stein Gold in Dermatology and Therapy (2021)

Article

COVID-19 hand hygiene measures for health care workers

Brigitte Dréno in European Journal of Dermatology (2021)

Article

The Skin Microbiome: A New Actor in Inflammatory Acne

Our understanding of the role of Cutibacterium acnes in the pathophysiology of acne has recently undergone a paradigm shift: rather than C. acnes hyperproliferation, it is the loss of balance between the differen...

Brigitte Dréno, Marie Ange Dagnelie… in American Journal of Clinical Dermatology (2020)

Article

Foreword

Brigitte Dréno, Gil Yosipovitch in American Journal of Clinical Dermatology (2020)

Article

Impact of initial treatment and prognostic factors on postprogression survival in BRAF-mutated metastatic melanoma treated with dacarbazine or vemurafenib ± cobimetinib: a pooled analysis of four clinical trials

We sought to identify patient subgroups with distinct postprogression overall survival (ppOS) outcomes and investigate the impact of original treatment assignment and initial postprogression treatment (ppRx) o...

Paolo A. Ascierto, Antoni Ribas, James Larkin… in Journal of Translational Medicine (2020)

Article

FASCE, the benefit of spironolactone for treating acne in women: study protocol for a randomized double-blind trial

Acne vulgaris has increased in women over the past 10 years; it currently affects 20–30% of women. The physiopathology of adult female acne is distinguished from that of teenagers essentially by two factors: h...

Alexandra Poinas, Marie Lemoigne, Sarah Le Naour, Jean-Michel Nguyen… in Trials (2020)

Article

Transcriptomic features of tumour-infiltrating CD4^lowCD8^high double positive αβ T cells in melanoma

Peripheral CD4⁺CD8⁺ double positive (DP) T cells are a phenotypically and functionally heterogeneous population depending on their origin and pathologic context. We previously identified among tumour infiltrating...

Tiphaine Parrot, Romain Oger, Mathilde Allard, Juliette Desfrançois… in Scientific Reports (2020)

Article

CICAFAST: comparison of a biological dressing composed of fetal fibroblasts and keratinocytes on a split-thickness skin graft donor site versus a traditional dressing: a randomized controlled trial

Wound repair is one of the most complex biological processes of human life. Allogeneic cell-based engineered skin substitutes provide off-the-shelf temporary wound coverage and act as biologically active dress...

Alexandra Poinas, Pierre Perrot, Judith Lorant, Olivier Nerrière… in Trials (2019)

Article

Impact of depth of response on survival in patients treated with cobimetinib ± vemurafenib: pooled analysis of BRIM-2, BRIM-3, BRIM-7 and coBRIM

This pooled analysis investigated the prognostic value of depth of response in two cohorts of patients with BRAF^V600-mutated metastatic melanoma treated with vemurafenib or cobimetinib plus vemurafenib.

Karl D. Lewis, James Larkin, Antoni Ribas, Keith T. Flaherty… in British Journal of Cancer (2019)

Article

Prevention and Reduction of Atrophic Acne Scars with Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel in Subjects with Moderate or Severe Facial Acne: Results of a 6-Month Randomized, Vehicle-Controlled Trial Using Intra-Individual Comparison

Very few clinical trials have investigated the effect of topical acne treatment on scarring.

Brigitte Dréno, Robert Bissonnette… in American Journal of Clinical Dermatology (2018)

Article

Health-related quality of life impact of cobimetinib in combination with vemurafenib in patients with advanced or metastatic BRAF^V600 mutation–positive melanoma

In the coBRIM study, cobimetinib plus vemurafenib (C+V) significantly improved survival outcomes vs placebo and vemurafenib (P+V) in patients with advanced/metastatic BRAF^V600-mutated melanoma. An analysis of hea...

Brigitte Dréno, Paolo A Ascierto, Victoria Atkinson… in British Journal of Cancer (2018)

Article

Efficient treatment of a metastatic melanoma patient with a combination of BRAF and MEK inhibitors based on circulating tumor DNA analysis: a case report

Fixed tissues are the standard samples used in routine practice for molecular testing. But sometimes tissues are lacking or difficult to obtain. In these cases, circulating tumor DNA released from tumor cells ...

Gaelle Quéreux, Guillaume Herbreteau, Anne-Chantal Knol… in BMC Research Notes (2017)

Article

Clinical features of serous retinopathy observed with cobimetinib in patients with BRAF-mutated melanoma treated in the randomized coBRIM study

Serous chorioretinopathy has been associated with MEK inhibitors, including cobimetinib. We describe the clinical features of serous retinopathy observed with cobimetinib in patients with BRAF ...

Luis de la Cruz-Merino, Lorenza Di Guardo… in Journal of Translational Medicine (2017)

Article

Melanoma and immunotherapy bridge 2015

MELANOMA BRIDGE 2015

Vashisht G. Y. Nanda, Weiyi Peng, Patrick Hwu… in Journal of Translational Medicine (2016)

Article

Erratum to: New Patient-Oriented Tools for Assessing Atrophic Acne Scarring

Alison Layton, Brigitte Dréno, Andrew Y. Finlay, Diane Thiboutot… in Dermatology and Therapy (2016)