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Tumor infiltrating lymphocytes as adjuvant treatment in stage III melanoma patients with only one invaded lymph node after complete resection: results from a multicentre, randomized clinical phase III trial

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  1. Article

    Open Access

    Phase I/II clinical trial of adoptive cell transfer of sorted specific T cells for metastatic melanoma patients

    Adoptive cell transfer (ACT) of tumor-specific T lymphocytes represents a relevant therapeutic strategy to treat metastatic melanoma patients. Ideal T-cells should combine tumor specificity and reactivity with...

    Brigitte Dréno, Amir Khammari, Agnès Fortun… in Cancer Immunology, Immunotherapy (2021)

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  2. Article

    Open Access

    Impact of depth of response on survival in patients treated with cobimetinib ± vemurafenib: pooled analysis of BRIM-2, BRIM-3, BRIM-7 and coBRIM

    This pooled analysis investigated the prognostic value of depth of response in two cohorts of patients with BRAFV600-mutated metastatic melanoma treated with vemurafenib or cobimetinib plus vemurafenib.

    Karl D. Lewis, James Larkin, Antoni Ribas, Keith T. Flaherty… in British Journal of Cancer (2019)

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  3. Article

    Open Access

    Health-related quality of life impact of cobimetinib in combination with vemurafenib in patients with advanced or metastatic BRAFV600 mutation–positive melanoma

    In the coBRIM study, cobimetinib plus vemurafenib (C+V) significantly improved survival outcomes vs placebo and vemurafenib (P+V) in patients with advanced/metastatic BRAFV600-mutated melanoma. An analysis of hea...

    Brigitte Dréno, Paolo A Ascierto, Victoria Atkinson… in British Journal of Cancer (2018)

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  4. Article

    Long-term follow-up of patients treated by adoptive transfer of melanoma tumor-infiltrating lymphocytes as adjuvant therapy for stage III melanoma

    The first analysis of our clinical trial on interest of using tumor-infiltrating lymphocytes (TIL) as adjuvant therapy for stage III (regional lymph nodes) melanoma was published in 2002 [5]. The aim of this pape...

    Amir Khammari, Jean-Michel Nguyen… in Cancer Immunology, Immunotherapy (2007)

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  5. Article

    Randomized trial of adoptive transfer of melanoma tumor-infiltrating lymphocytes as adjuvant therapy for stage III melanoma

    The aim of this study was to demonstrate the interest of using tumor-infiltrating lymphocytes (TIL) as adjuvant therapy for stage III (regional lymph nodes) melanoma. After lymph node excision, patients witho...

    Brigitte Dréno, Jean-Michel Nguyen, Amir Khammari… in Cancer Immunology, Immunotherapy (2002)

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