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Article
Population pharmacokinetics and pharmacodynamics of efmarodocokin alfa (IL-22Fc)
Efmarodocokin alfa (IL-22Fc) is a fusion protein of human IL-22 linked to the crystallizable fragment (Fc) of human IgG4. It has been tested in multiple indications including inflammatory bowel disease (IBD). ...
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Article
Open AccessB-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin
B-lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL) are members of the tumor necrosis factor (TNF) family that regulate B-cell maturation, survival, and function. They are overexpressed ...
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Article
Erratum: Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice
Nature Immunology 5, 752–760 (2004). The published version of this article failed to include the microarray accession numbers. They are listed here: Geo microarray accession numbers. GSE1304, Control and Il31 ...
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Article
Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice
T cell–derived cytokines are important in the development of an effective immune response, but when dysregulated they can promote disease. Here we identify a four-helix bundle cytokine we have called interleuk...