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  1. Article

    Open Access

    Targeting SphK1/2 by SKI-178 inhibits prostate cancer cell growth

    Sphingosine kinases (SphK), including SphK1 and SphK2, are important enzymes promoting progression of prostate cancer. SKI-178 is a novel and highly potent SphK1/2 dual inhibitor. We here tested the potential ...

    Lu **, ** Zhu, Linya Yao, Gang Shen, Bo-xin Xue, Wei Tao in Cell Death & Disease (2023)

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  2. Article

    Open Access

    GNE-493 inhibits prostate cancer cell growth via Akt-mTOR-dependent and -independent mechanisms

    GNE-493 is a novel PI3K/mTOR dual inhibitor with improved metabolic stability, oral bioavailability, and excellent pharmacokinetic parameters. Here GNE-493 potently inhibited viability, proliferation, and migr...

    Lu **, Wei Zhang, Ming-Yu Yao, Ye Tian, Bo-xin Xue, Wei Tao in Cell Death Discovery (2022)

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