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  1. Article

    Open Access

    The description of protein internal motions aids selection of ligand binding poses by the INPHARMA method

    Protein internal motions influence observables of NMR experiments. The effect of internal motions occurring at the sub-nanosecond timescale can be described by NMR order parameters. Here, we report that the us...

    Benjamin Stauch, Julien Orts, Teresa Carlomagno in Journal of Biomolecular NMR (2012)

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  2. Article

    Publisher Correction: Structural basis of ligand recognition at the human MT1 melatonin receptor

    Change history: In this Letter, the rotation signs around 90°, 135° and 15° were missing and in the HTML, Extended Data Tables 2 and 3 were the wrong tables; these errors have been corrected online.

    Benjamin Stauch, Linda C. Johansson, John D. McCorvy, Nilkanth Patel, Gye Won Han… in Nature (2019)

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    Article

    Structural basis of ligand recognition at the human MT1 melatonin receptor

    Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that maintains circadian rhythms1 by synchronization to environmental cues and is involved in diverse physiological processes2 such as the regulation of ...

    Benjamin Stauch, Linda C. Johansson, John D. McCorvy, Nilkanth Patel, Gye Won Han… in Nature (2019)

  4. No Access

    Article

    XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity

    The human MT1 and MT2 melatonin receptors1,2 are G-protein-coupled receptors (GPCRs) that help to regulate circadian rhythm and sleep patterns3. Drug development efforts have targeted both receptors for the treat...

    Linda C. Johansson, Benjamin Stauch, John D. McCorvy, Gye Won Han, Nilkanth Patel… in Nature (2019)

  5. Article

    Open Access

    Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors

    Cysteinyl leukotriene G protein-coupled receptors CysLT1 and CysLT2 regulate pro-inflammatory responses associated with allergic disorders. While selective inhibition of CysLT1R has been used for treating asthma ...

    Anastasiia Gusach, Aleksandra Luginina, Egor Marin… in Nature Communications (2019)

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  6. No Access

    Article

    Virtual discovery of melatonin receptor ligands to modulate circadian rhythms

    The neuromodulator melatonin synchronizes circadian rhythms and related physiological functions through the actions of two G-protein-coupled receptors: MT1 and MT2. Circadian release of melatonin at night from th...

    Reed M. Stein, Hye ** Kang, John D. McCorvy, Grant C. Glatfelter… in Nature (2020)

  7. No Access

    Article

    Serial femtosecond crystallography

    With the advent of X-ray free-electron lasers (XFELs), new, high-throughput serial crystallography techniques for macromolecular structure determination have emerged. Serial femtosecond crystallography (SFX) a...

    Thomas R. M. Barends, Benjamin Stauch, Vadim Cherezov… in Nature Reviews Methods Primers (2022)