255 Result(s)

Article

Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants

Acid-sensing ion channels (ASICs) are trimeric proton-gated cation channels that play a role in neurotransmission and pain sensation. The snake venom-derived peptides, mambalgins, exhibit potent analgesic effe...

Ben Cristofori-Armstrong, Elena Budusan… in Cellular and Molecular Life Sciences (2024)

Article

ACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway

The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is expressed in the intestine, collaborates with broad neutral am...

**ze Li, Yingli Yan, Yang Fu, Zhe Chen… in Cellular & Molecular Biology Letters (2024)

Article

Inhibition of key DNA double strand break repair protein kinases enhances radiosensitivity of head and neck cancer cells to X-ray and proton irradiation

Ionising radiation (IR) is widely used in cancer treatment, including for head and neck squamous cell carcinoma (HNSCC), where it induces significant DNA damage leading ultimately to tumour cell death. Among t...

Maria Rita Fabbrizi, Thomas J. Doggett, Jonathan R. Hughes… in Cell Death Discovery (2024)

Article

Correction: Flotillins affect LPS-induced TLR4 signaling by modulating the trafficking and abundance of CD14

Orest V. Matveichuk, Anna Ciesielska… in Cellular and Molecular Life Sciences (2024)

Article

Dynamic changes in RNA m⁶A and 5 hmC influence gene expression programs during macrophage differentiation and polarisation

RNA modifications are essential for the establishment of cellular identity. Although increasing evidence indicates that RNA modifications regulate the innate immune response, their role in monocyte-to-macropha...

Natalia Pinello, Renhua Song, Quintin Lee… in Cellular and Molecular Life Sciences (2024)

Article

Flotillins affect LPS-induced TLR4 signaling by modulating the trafficking and abundance of CD14

Lipopolysaccharide (LPS) induces a strong pro-inflammatory reaction of macrophages upon activation of Toll-like receptor 4 (TLR4) with the assistance of CD14 protein. Considering a key role of plasma membrane ...

Orest V. Matveichuk, Anna Ciesielska… in Cellular and Molecular Life Sciences (2024)

Article

Enhancing Pisum sativum growth and symbiosis under heat stress: the synergistic impact of co-inoculated bacterial consortia and ACC deaminase-lacking Rhizobium

The 1-aminocyclopropane-1-carboxylate (ACC) deaminase is a crucial bacterial trait, yet it is not widely distributed among rhizobia. Hence, employing a co-inoculation approach that combines selected plant grow...

Roukaya Ben Gaied, Imed Sbissi, Mohamed Tarhouni… in Archives of Microbiology (2024)

Article

Selective deletion of E3 ubiquitin ligase FBW7 in VE-cadherin-positive cells instigates diffuse large B-cell lymphoma in mice in vivo

During the maturation of hematopoietic stem/progenitor cells (HSPCs) to fully differentiated mature B lymphocytes, develo** lymphocytes may undergo malignant transformation and produce B-cell lymphomas. Emer...

Zhaohua Cai, Shao** You, Zhixue Liu, ** Song, Fujie Zhao… in Cell Death & Disease (2024)

Article

Targeting NEDD8 suppresses surgical stress-facilitated metastasis of colon cancer via restraining regulatory T cells

Regulatory T cells (Tregs) are a key determinant for the immunosuppressive and premetastatic niche for cancer progression after surgery resection. However, the precise mechanisms regulating Tregs function duri...

Yi Jiang, Shenjia Gao, Hao Sun, **nyi Wu, Jiahui Gu, Han Wu… in Cell Death & Disease (2024)

Article

Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylation

Obesity is characterized by chronic low-grade inflammation, which is driven by macrophage infiltration in adipose tissue and leads to elevated cytokines such as interleukin-1β (IL-1β) in the circulation and ti...

Yang**g Jiang, Min Liang, Long Chen, Jian Wang… in Cellular and Molecular Life Sciences (2023)

Article

The mitochondrial NADH shuttle system is a targetable vulnerability for Group 3 medulloblastoma in a hypoxic microenvironment

Medulloblastoma is a cancerous brain tumor that affects mostly children. Among the four groups defined by molecular characteristics, Group 3, the least well characterized, is also the least favorable, with a s...

J. Contenti, Y. Guo, A. Mazzu, M. Irondelle, M. Rouleau, C. Lago… in Cell Death & Disease (2023)

Article

Major vault protein (MVP) suppresses aging- and estrogen deficiency-related bone loss through Fas-mediated apoptosis in osteoclasts

Osteoclasts (OCs), derived from monocyte/macrophage lineage, are key orchestrators in bone remodeling. Targeting osteoclast apoptosis is a promising approach to cut down excessive osteoclast numbers, and thus ...

Ruobing Wang, Yan Yang, Zhongyin Zhang, Na Zhao, Erik A. C. Wiemer… in Cell Death & Disease (2023)

Article

Allicin promotes functional recovery in ischemic stroke via glutathione peroxidase-1 activation of Src-Akt-Erk

Allicin exhibits various pharmacological activities and has been suggested to be beneficial in the treatment of stroke. However, the underlying mechanisms are largely unknown. Here, we confirmed that allicin p...

Fei Zhuang, **n Shi, Sen Qiao, Bin Liu, Zhimei Wang, Huanhuan Huo… in Cell Death Discovery (2023)

Article

N-acetyltransferase 10 promotes cutaneous wound repair via the NF-κB-IL-6 axis

Cutaneous wound healing, an integral part for protection of skin barrier, is a complex biological process and intimately associated with keratinocyte migration. However, mechanisms regulating keratinocyte migr...

Ben Wang, ** Zhang, Guo Li, Chenzhong Xu, Langmei Yang, Jie Zhang… in Cell Death Discovery (2023)

Article

A GSTP1-mediated lactic acid signaling promotes tumorigenesis through the PPP oxidative branch

Lactic acidosis is a feature of solid tumors and plays fundamental role(s) rendering cancer cells to adapt to diverse metabolic stresses, but the mechanism underlying its roles in redox homeostasis remains elu...

Yandi Sun, Qian He, **gjia Li, Ze Yang, Mashaal Ahmad, Yindan Lin… in Cell Death & Disease (2023)

Article

Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology

Inhibition of phosphodiesterase 4D (PDE4D) enzymes has been investigated as therapeutic strategy to treat memory problems in Alzheimer’s disease (AD). Although PDE4D inhibitors are effective in enhancing memor...

Dean Paes, Melissa Schepers, Emily Willems… in Cellular and Molecular Life Sciences (2023)