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Article
Open AccessEndothelial dysfunction in breast cancer survivors on aromatase inhibitors: changes over time
Breast cancer is estimated to comprise about 290,560 new cases in 2022. Aromatase inhibitors (AIs) are recommended as adjuvant treatment for estrogen-receptor positive (ER+) breast carcinoma in postmenopausal ...
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Article
The Association of Social Determinants of Health with Somali Refugee Mother–Child Caries
Minnesota has the largest population of Somali refugees with the majority depending on public insurance for dental care. The social determinants of health (SDOH) framework is helpful to identify factors that m...
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Article
Bidirectional long short-term memory for surgical skill classification of temporally segmented tasks
The majority of historical surgical skill research typically analyzes holistic summary task-level metrics to create a skill classification for a performance. Recent advances in machine learning allow time seri...
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Article
Open AccessImpact of gastroesophageal reflux on longitudinal lung function and quantitative computed tomography in the COPDGene cohort
Gastroesophageal reflux disease (GERD) is a common comorbidity in chronic obstructive pulmonary disease (COPD) and has been associated with increased risk of acute exacerbations, hospitalization, emergency roo...
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Article
The effect of video playback speed on surgeon technical skill perception
Finding effective methods of discriminating surgeon technical skill has proved a complex problem to solve computationally. Previous research has shown that obtaining non-expert crowd evaluations of surgical p...
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Article
Open AccessSmoking-related symptomatology in pregnant smokers during ad libitum smoking and following overnight smoking abstinence
Current literature suggests there may be a relationship between sex hormones, which dramatically increase during pregnancy, and nicotine use behaviors. We hypothesized that higher progesterone and progesterone...
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Article
Open AccessA soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease
Lewy body diseases are neurodegenerative disorders characterized by Lewy bodies in the brain. Lewy body dementia (LBD) refers to two forms of Lewy body disease: Parkinson’s disease with dementia (PDD) and deme...
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Article
Open AccessCharacterizing the “sweet spot” for the preservation of a T-cell line using osmolytes
This study examined the post-thaw recovery of Jurkat cells cryopreserved in single osmolyte solutions containing sucrose, glycerol or isoleucine, as well as in a combination of the three osmolytes. Cell respon...
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Article
Open AccessEarly prediction of outcome after severe traumatic brain injury: a simple and practical model
Traumatic brain injury (TBI) is a heterogeneous syndrome with a broad range of outcome. We developed a simple model for long-term outcome prognostication after severe TBI.
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Article
Open AccessEvaluating methods for combining rare variant data in pathway-based tests of genetic association
Analyzing sets of genes in genome-wide association studies is a relatively new approach that aims to capitalize on biological knowledge about the interactions of genes in biological pathways. This approach, ca...
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Article
Open AccessEvaluating methods for the analysis of rare variants in sequence data
A number of rare variant statistical methods have been proposed for analysis of the impending wave of next-generation sequencing data. To date, there are few direct comparisons of these methods on real sequenc...