27 Result(s)

Article

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-a...

Anqi Wang, Jiayi Shen, Alex A. Rodriguez, Edward J. Saunders, Fei Chen… in Nature Genetics (2023)

Article

Overall and central obesity and prostate cancer risk in African men

African men are disproportionately affected by prostate cancer (PCa). Given the increasing prevalence of obesity in Africa, and its association with aggressive PCa in other populations, we examined the relatio...

Ilir Agalliu, Wei-Kaung Jerry Lin, Janice S. Zhang… in Cancer Causes & Control (2022)

Article

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studie...

David V. Conti, Burcu F. Darst, Lilit C. Moss, Edward J. Saunders… in Nature Genetics (2021)

Article

Serum androgens and prostate cancer risk: results from the placebo arm of the Prostate Cancer Prevention Trial

Compelling and long-standing data suggest that androgens play an important role in the development of both normal prostate epithelium and prostate cancer. Although testosterone administration can induce prosta...

Jeannette M. Schenk, Cathee Till, Ann W. Hsing… in Cancer Causes & Control (2016)

Article

Prospective study of human herpesvirus type 8 serostatus and prostate cancer risk in the placebo arm of the Prostate Cancer Prevention Trial

Human herpesvirus type 8 (HHV-8), a gamma herpesvirus associated with Kaposi’s sarcoma, has been proposed as a candidate risk factor for prostate cancer (PCa) because of its detection in benign and malignant p...

Siobhan Sutcliffe, Cathee Till, Frank J. Jenkins… in Cancer Causes & Control (2015)

Article

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

Rosalind Eeles, Christopher Haiman and colleagues report genome-wide association and meta-analyses of prostate cancer in populations of European, African, Japanese and Latino ancestry. They identify 23 new sus...

Ali Amin Al Olama, Zsofia Kote-Jarai, Sonja I Berndt, David V Conti… in Nature Genetics (2014)

Article

Prospective study of cytomegalovirus serostatus and prostate cancer risk in the Prostate Cancer Prevention Trial

To investigate serologic evidence of infection by cytomegalovirus (CMV), a herpesvirus with known oncogenic potential that has been detected in malignant prostate tissue, in relation to prostate cancer (PCa) r...

Siobhan Sutcliffe, Cathee Till, Charlotte A. Gaydos… in Cancer Causes & Control (2012)

Article

Detectable clonal mosaicism and its relationship to aging and cancer

Luis Pérez-Jurado, Stephen Chanock and colleagues detect clonal chromosomal abnormalities in peripheral blood or buccal samples from individuals in the general population. They show that the frequency of such ...

Kevin B Jacobs, Meredith Yeager, Weiyin Zhou, Sholom Wacholder… in Nature Genetics (2012)

Article

Physical activity, diabetes, and thyroid cancer risk: a pooled analysis of five prospective studies

Although many studies have linked obesity with increased risk of thyroid cancer, few have investigated the role of obesity-related lifestyle characteristics and medical conditions in the etiology of this disea...

Cari M. Kitahara, Elizabeth A. Platz, Laura E. Beane Freeman… in Cancer Causes & Control (2012)

Article

Improved imputation of common and uncommon SNPs with a new reference set

Zhaoming Wang, Kevin B Jacobs, Meredith Yeager, Amy Hutchinson… in Nature Genetics (2012)

Article

Medical history and the risk of biliary tract cancers in Shanghai, China: implications for a role of inflammation

Several lines of evidence suggest that inflammation may play a role in the etiology of biliary tract cancers. To examine further the role of inflammation, we evaluated the associations between self-reported in...

Gabriella Andreotti, Enju Liu, Yu-Tang Gao, Mahboobeh Safaeian… in Cancer Causes & Control (2011)

Article

Dietary carbohydrate, glycemic index, glycemic load, and risk of prostate cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort

To evaluate the associations between dietary carbohydrate, glycemic index (GI), glycemic load (GL), and incident prostate cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) coh...

James M. Shikany, Andrew P. Flood, Cari M. Kitahara… in Cancer Causes & Control (2011)

Article

Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21

Christopher Haiman and colleagues report a genome-wide association study for prostate cancer in African-American males drawn from 11 epidemiological studies of prostate cancer, with replication including indiv...

Christopher A Haiman, Gary K Chen, William J Blot, Sara S Strom… in Nature Genetics (2011)

Article

Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3

Paul Brennan, Stephen Chanock and colleagues performed a genome-wide association study for renal carcinoma. They identified two genetic susceptibility loci.

Mark P Purdue, Mattias Johansson, Diana Zelenika, Jorge R Toro… in Nature Genetics (2011)

Article

Intra-individual variation in serum C-reactive protein over 4 years: an implication for epidemiologic studies

Data on long-term intra-individual variability in high-sensitivity C-reactive protein (hsCRP) are needed to determine whether one measurement adequately reflects usual levels in prospective studies of on the e...

Elizabeth A. Platz, Siobhan Sutcliffe, Angelo M. De Marzo… in Cancer Causes & Control (2010)

Article

Diabetes mellitus and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

A history of diabetes has been fairly consistently related to a reduced prostate cancer risk, but previous investigations have not always addressed whether the relation with diabetes varies by prostate cancer ...

Michael F. Leitzmann, Jiyoung Ahn, Demetrius Albanes… in Cancer Causes & Control (2008)