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  1. No Access

    Article

    Population Pharmacokinetics and Pharmacodynamics of Carfilzomib in Combination with Rituximab, Ifosfamide, Carboplatin, and Etoposide in Adult Patients with Relapsed/Refractory Diffuse Large B Cell Lymphoma

    In patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL), salvage chemotherapy regimens (e.g., rituximab, ifosfamide, carboplatin, and etoposide, R-ICE) yield poor outcomes. Carfilzomib...

    Lan-Hsi Lin, Mohammad Ghasemi, Sarah M. Burke, Cory K. Mavis… in Targeted Oncology (2023)

  2. No Access

    Article

    The Value of Pharmacogenetics to Reduce Drug-Related Toxicity in Cancer Patients

    Many anticancer drugs cause adverse drug reactions (ADRs) that negatively impact safety and reduce quality of life. The typical narrow therapeutic range and exposure-response relationships described for antica...

    Doreen Z. Mhandire, Andrew K. L. Goey in Molecular Diagnosis & Therapy (2022)

  3. Article

    Open Access

    Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics

    Since its clinical introduction in 1998, the topoisomerase I inhibitor irinotecan has been widely used in the treatment of solid tumors, including colorectal, pancreatic, and lung cancer. Irinotecan therapy is...

    Femke M. de Man, Andrew K. L. Goey, Ron H. N. van Schaik… in Clinical Pharmacokinetics (2018)

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  4. No Access

    Article

    The Effect of St John’s Wort on the Pharmacokinetics of Docetaxel

    St John’s wort (SJW), a herbal antidepressant, is commonly used by cancer patients, and its component hyperforin is a known inducer of the cytochrome P450 (CYP) isoenzyme 3A4. Here, the potential pharmacokinet...

    Andrew K. L. Goey, Irma Meijerman, Hilde Rosing… in Clinical Pharmacokinetics (2014)

  5. No Access

    Article

    The effect of grape seed extract on the pharmacokinetics of dextromethorphan in healthy volunteers

    Grape seed extract (GSE) has been shown to inhibit the cytochrome P450 (CYP) 2D6 isoenzyme in vitro. To determine the clinical effect of GSE on CYP2D6, the pharmacokinetic interaction between GSE and the sensi...

    Andrew K. L. Goey, Irma Meijerman… in European Journal of Clinical Pharmacology (2013)

  6. Article

    Open Access

    GBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behavior

    Mania is a core feature of bipolar disorder (BD) that traditionally is assessed using rating scales. Studies using a new human behavioral pattern monitor (BPM) recently demonstrated that manic BD patients exhi...

    Jared W. Young, Andrew K. L. Goey, Arpi Minassian, William Perry… in Psychopharmacology (2010)

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