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Individual sleep need is flexible and dynamically related to cognitive function
Given that sleep deprivation studies consistently show that short sleep causes neurocognitive deficits, the effects of insufficient sleep on brain health and cognition are of great interest and concern. Here w...
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Open AccessNo phenotypic or genotypic evidence for a link between sleep duration and brain atrophy
Short sleep is held to cause poorer brain health, but is short sleep associated with higher rates of brain structural decline? Analysing 8,153 longitudinal MRIs from 3,893 healthy adults, we found no evidence ...
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Open AccessCirculating S100B levels at birth and risk of six major neuropsychiatric or neurological disorders: a two-sample Mendelian Randomization Study
Circulating levels of the astrocytic marker S100B have been associated with risk of neuropsychiatric or neurological disorders. However, reported effects have been inconsistent, and no causal relations have ye...
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Development of the P300 from childhood to adulthood: a multimodal EEG and MRI study
Maturation of attentional processes is central to cognitive development. The electrophysiological P300 is associated with rapid allocation of attention, and bridges stimulus and response processing. P300 is am...
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Open AccessThe corpus callosum as anatomical marker of intelligence? A critical examination in a large-scale developmental study
Intellectual abilities are supported by a large-scale fronto-parietal brain network distributed across both cerebral hemispheres. This bihemispheric network suggests a functional relevance of inter-hemispheric...
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Neuroimaging Results Impose New Views on Alzheimer’s Disease—the Role of Amyloid Revised
Huge progress has been made in unraveling the mysteries of Alzheimer’s disease (AD), but we still do not understand the basic mechanisms that set off the cascade of pathological events. In May 2011, the Nation...
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Effects of prenatal opiate exposure on brain development – a call for attention
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Interactive effects of APOE and CHRNA4 on attention and white matter volume in healthy middle-aged and older adults
In the present study, we investigated age-related changes in interactions between efficiency of neuronal repair mechanisms and efficiency of cholinergic neurotransmission in the context of attentional orientin...
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On the Topography of P3a and P3b Across the Adult Lifespan—A Factor-Analytic Study Using Orthogonal Procrustes Rotation
The purpose of this study was to investigate whether the activity distribution of P3a and P3b across the scalp changes with age or remains identical. 103 well-functioning adults, 20-90 years, performed a visua...
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P300 and Neuropsychological Tests as Measures of Aging: Scalp Topography and Cognitive Changes
The rationale for the present study was to investigate several aspects of P300 topography in relation to aging and neuropsychological measures. We administered an auditory oddball ERP task to 72 participants a...