26 Result(s)
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Allison Jones
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Open AccessDNA methylation at quantitative trait loci (mQTLs) varies with cell type and nonheritable factors and may improve breast cancer risk assessment
To individualise breast cancer (BC) prevention, markers to follow a person’s changing environment and health extending beyond static genetic risk scores are required. Here, we analysed cervical and breast DNA ...
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Open AccessDNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test
Cervical screening using primary human papilloma virus (HPV) testing and cytology is being implemented in several countries. Cytology as triage for colposcopy referral suffers from several shortcomings. HPV te...
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Open AccessThe WID-CIN test identifies women with, and at risk of, cervical intraepithelial neoplasia grade 3 and invasive cervical cancer
Cervical screening is transitioning from primary cytology to primary human papillomavirus (HPV) testing. HPV testing is highly sensitive but there is currently no high-specificity triage method for colposcopy ...
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Open AccessCorrection: Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women
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Open AccessAuthor Correction: Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock
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Open AccessAntiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women
Breast cancer is a leading cause of death in premenopausal women. Progesterone drives expansion of luminal progenitor cells, leading to the development of poor-prognostic breast cancers. However, it is not kn...
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Open AccessSusceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock
A variety of epigenetic clocks utilizing DNA methylation changes have been developed; these clocks are either tissue-independent or designed to predict chronological age based on blood or saliva samples. Wheth...
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Open AccessThe WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples
Genetic and non-genetic factors contribute to breast cancer development. An epigenome-based signature capturing these components in easily accessible samples could identify women at risk. Here, we analyse the ...
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Open AccessThe DNA methylome of cervical cells can predict the presence of ovarian cancer
The vast majority of epithelial ovarian cancer arises from tissues that are embryologically derived from the Müllerian Duct. Here, we demonstrate that a DNA methylation signature in easy-to-access Müllerian Du...
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Open AccessDNA methylation signatures to predict the cervicovaginal microbiome status
The composition of the microbiome plays an important role in human health and disease. Whether there is a direct association between the cervicovaginal microbiome and the host’s epigenome is largely unexplored.
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Epigenome-based cancer risk prediction: rationale, opportunities and challenges
Epigenetic misprogramming is an essential component of cancer development.
DNA methylation-based risk-predi...
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Open AccessMethylation patterns in serum DNA for early identification of disseminated breast cancer
Monitoring treatment and early detection of fatal breast cancer (BC) remains a major unmet need. Aberrant circulating DNA methylation (DNAme) patterns are likely to provide a highly specific cancer signal. We ...
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Open AccessThe potential of circulating tumor DNA methylation analysis for the early detection and management of ovarian cancer
Despite a myriad of attempts in the last three decades to diagnose ovarian cancer (OC) earlier, this clinical aim still remains a significant challenge. Aberrant methylation patterns of linked CpGs analyzed in...
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Open AccessErratum to: The integrative epigenomic-transcriptomic landscape of ER positive breast cancer
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Open AccessEpigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution
The exact timing and contribution of epigenetic reprogramming to carcinogenesis are unclear. Women harbouring BRCA1/2 mutations demonstrate a 30–40-fold increased risk of high-grade serous extra-uterine Müllerian...
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Open AccessStochastic epigenetic outliers can define field defects in cancer
There is growing evidence that DNA methylation alterations may contribute to carcinogenesis. Recent data also suggest that DNA methylation field defects in normal pre-neoplastic tissue represent infrequent sto...
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Open AccessDNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer
Identifying molecular alterations in normal tissue adjacent to cancer is important for understanding cancer aetiology and designing preventive measures. Here we analyse the DNA methylome of 569 breast tissue s...
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Open AccessA donor-specific epigenetic classifier for acute graft-versus-host disease severity in hematopoietic stem cell transplantation
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for many hematological conditions. Acute graft-versus-host disease (aGVHD) is a prevalent immune-mediated complication followin...
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Open AccessThe integrative epigenomic-transcriptomic landscape of ER positive breast cancer
While recent integrative analyses of copy number and gene expression data in breast cancer have revealed a complex molecular landscape with multiple subtypes and many oncogenic/tumour suppressor driver events,...
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Open AccessHOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer
Understanding carboplatin resistance in ovarian cancer is critical for the improvement of patients’ lives. Multipotent mesenchymal stem cells or an aggravated epithelial to mesenchymal transition phenotype of ...
