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    Article

    The nuclear translocation of ERK1/2 as an anticancer target

    A hallmark of the ERK1/2 functioning is their nuclear translocation, which is mainly required for the induction of proliferation. Activated ERK1/2 molecules that remain in the cytoplasm initiate other activiti...

    Alexander Plotnikov, Karen Flores, Galia Maik-Rachline in Nature Communications (2015)

  2. Article

    Open Access

    High content image analysis reveals function of miR-124 upstream of Vimentin in regulating motor neuron mitochondria

    microRNAs (miRNAs) are critical for neuronal function and their dysregulation is repeatedly observed in neurodegenerative diseases. Here, we implemented high content image analysis for investigating the impact...

    Tal Yardeni, Raquel Fine, Yuvraj Joshi, Tal Gradus-Pery, Noga Kozer in Scientific Reports (2018)

  3. Article

    Open Access

    PRMT1 inhibition induces differentiation of colon cancer cells

    Differentiation therapy has been recently revisited as a prospective approach in cancer therapy by targeting the aberrant growth, and repairing the differentiation and cell death programs of cancer cells. Howe...

    Alexander Plotnikov, Noga Kozer, Galit Cohen, Silvia Carvalho in Scientific Reports (2020)