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Article
The possible role of neutrophil proteinases in damage to articular cartilage
The proteolytic degradation of articular cartilage that is seen in the arthritides affects both of the major structural components of the tissue, proteoglycan and collagen. Neutrophil leucocytes are abundant i...
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Article
Evolution of proteins of the cystatin superfamily
We have examined the amino acid sequences of a number of proteins that have been suggested to be related to chicken cystatin, a protein from chicken egg white that inhibits cysteine proteinases. On the basis o...
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Article
The possible role of neutrophil proteinases in damage to articular cartilage
The proteolytic degradation of articular cartilage that is seen in the arthritides affects both of the major structural components of the tissue, proteoglycan and collagen. Neutrophil leucocytes are abundant i...
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Article
Families and clans of cysteine peptidases
The known cysteine peptidases have been classified into 35 sequence families. We argue that these have arisen from at least five separate evolutionary origins, each of which is represented by a set of one or m...
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Article
An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation
Foreign protein antigens must be broken down within endosomes or lysosomes to generate suitable peptides that will form complexes with class II major histocompatibility complex molecules for presentation to T ...
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Article
Open AccessA comparison of Pfam and MEROPS: Two databases, one comprehensive, and one specialised.
We wished to compare two databases based on sequence similarity: one that aims to be comprehensive in its coverage of known sequences, and one that specialises in a relatively small subset of known sequences. ...