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Article
Genetic heterogeneity of glucose 6-phosphate dehydrogenase deficiency in Sardinia
Glucose 6-phosphate dehydrogenase (G6PD) activity was assayed quantitatively in red cells from 100 consecutive G6PD-deficient newborn male babies born in a city hospital in Sassari, Sardinia. In four cases G6P...
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Article
TRH raises cytosolic Ca2+ in human adenomatous lactotrophs
The effect of TRH on cytosolic free calcium concentrations, [Ca2+]i, was evaluated on cell suspensions obtained from 6 human PRL secreting pituitary adenomas. In these cells resting [Ca2+]i levels were variable (...
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Article
59 Analysis of N-Ras gene mutations in medulloblastomas by polymerase chain reaction and oligonucleotide probes in formalin-fixed, paraffin-embedded tissues
Precise data on the incidence of transforming ras oncogenes in pediatric tumors and the correlations with the histo-pathological properties of the tumor are very limited. Additionally the presence of ras activ...
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Article
Abnormal transduction of dopamine signal in human nonfunctioning pituitary adenomas
It is well established that dopamine (DA) plays an important role in inhibiting anterior pituitary function. DA receptors present in the pituitary show the pharmacological and biochemical characteristics of th...
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Article
Immunodetection of glycoprotein hormone subunits in nonfunctioning and glycoprotein hormone-secreting pituitary adenomas
While it is established that nonfunctioning pituitary adenomas (NFPA) produce a spectrum of glycoprotein hormones, the ability of glycoprotein hormone-secreting adenomas to synthesize hormones other than those in...
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Article
Gonadotropin-releasing hormone initiates multiple signaling pathways in human GH-secreting adenomas
Abnormal GH responses to GnRH test, observed in about 15% of patients with acromegaly, have been reported exclusively in patients bearing tumors without gsp mutation. The absence of responsiveness to GnRH in g...
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Article
Effects of chronic retinoid administration on pituitary function
It has been reported that retinoids may affect hypothalamic-pituitary-thyroid axis, causing central hypothyroidism. In the present study, we evaluated pituitary function in 11 male psoriatic patients at baseli...
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Article
Growth hormone replacement therapy in growth hormone deficient children and adults: Effects on hemochrome
Several lines of evidence have suggested a role of the GH/IGF-I axis in the regulation of hemochrome. Many studies have been carried out in GH deficient children and adults about this topic, reporting predomin...
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Article
Dopamine D2 receptor gene polymorphisms and response to cabergoline therapy in patients with prolactin-secreting pituitary adenomas
Dopamine-agonist cabergoline (CB) reduces prolactin (PRL) secretion and tumor size in 80% of patients with prolactin-secreting adenomas (PRL-omas) by binding type 2 dopamine receptor (DRD2). The mechanisms res...
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Article
The trans-sphenoidal resection of pituitary adenomas in elderly patients and surgical risk
In western countries, the process of “ageing of the population” is increasingly forcing clinical medicine to find answers for pathologies affecting the elder segments of our community. In this respect, pituita...
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Article
Open Access[18F]FDG-PET/CT texture analysis in thyroid incidentalomas: preliminary results
significance of incidental thyroid 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) uptake on positron emission tomography/computed tomography (PET/CT) scans remains controversial. We aimed to evaluate the ability of [
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Article
Approach to hyponatremia according to the clinical setting: Consensus statement from the Italian Society of Endocrinology (SIE), Italian Society of Nephrology (SIN), and Italian Association of Medical Oncology (AIOM)
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Article
Functional hypothalamic and drug-induced amenorrhea: an overview
Functional hypothalamic amenorrhea (FHA) is a form of chronic anovulation not due to identifiable organic causes and with adverse health consequences. The identification of women with this disorder or the prec...
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Article
A 2019 update on TSH-secreting pituitary adenomas
Thyrotropin-secreting pituitary adenomas (TSH-omas) present with signs and symptoms of hyperthyroidism and they are characterized by elevated serum levels of free thyroid hormones with measurable TSH levels. T...
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Article
A standardised diagnostic approach to pituitary neuroendocrine tumours (PitNETs): a European Pituitary Pathology Group (EPPG) proposal
The 2017 World Health Organization (WHO) classification proposes to type and subtype primary adenohypophyseal tumours according to their cell lineages with the aim to establish more uniform tumour groups. The ...
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Article
Impact of age on postsurgical outcomes of nonfunctioning pituitary adenomas
The management of pituitary adenomas in the elderly has become a relevant clinical issue, in relationship with improved life expectancy and spreading use of imaging techniques. In this single-center and retros...
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Article
Thyroid dysfunction in COVID-19 patients
“Non thyroidal illness syndrome” (NTIS) or “euthyroid sick syndrome” (ESS) is a possible biochemical finding in euthyroid patients with severe diseases. It is characterized by a reduction of serum T3 (fT3), somet...
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Article
Direct effects of octreotide on osteoblast cell proliferation and function
Octreotide (OCT) is a first-generation somatostatin analog (SSA) used in the treatment of acromegaly and neuroendocrine tumors (NETs). In both diseases, OCT interacts with somatostatin receptors 2 and 5 (SSTR2...
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Article
Clinical and radiological presentation of parasellar ectopic pituitary adenomas: case series and systematic review of the literature
Parasellar ectopic pituitary adenomas (pEPAs) are extremely rare tumors located out of the sella turcica. PEPAs are heterogeneous entities in terms of anatomical localization and secretion of anterior pituitar...
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Article
Open AccessGender-related differences in patients with carcinoid syndrome: new insights from an Italian multicenter cohort study
The incidence of neuroendocrine neoplasm (NEN) and related carcinoid syndrome (CaS) has increased markedly in recent decades, and women appear to be more at risk than men. As per other tumors, gender may be re...
