245 Result(s)
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Article
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Biochemistry, general
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Article
Synthesis, structure-activity relationship and evaluation of antifungal activity of tryptanthrin derivatives against drug-resistant Candida albicans
With the increasing of Candida albicans infections year by year, and the widespread use of azole drugs, especially fluconazole has led to the emergence of drug resistance. Therefore, new antifungal agents are urg...
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Open AccessGenetic Prediction of Osteoporosis by Anti-Müllerian Hormone Levels and Reproductive Factors in Women: A Mendelian Randomization Study
Previous observational studies have suggested that anti-Müllerian hormone (AMH) and reproductive factors are linked to reduced bone mineral density (BMD) and an increased risk of osteoporosis (OP) in women. Ho...
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In situ growth of dual-responsive polymer as coating for open tubular capillary electrochromatographic separation of epimedins
Recently, open tubular capillary electrochromatography (OT-CEC) has captured considerable interest; its efficient separation capability hinges on the interactions between analytes and polymer coatings. However, i...
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Exploring the Correlation Between Varied Serum Iodine Nutritional Levels and Anti-Thyroglobulin Antibodies
Iodine deficiency results in elevated thyroglobulin (Tg) concentrations, with high iodine Tg being more immunogenic than low iodine Tg. The study investigated the correlation between serum iodine concentration...
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Open AccessThe COP9 signalosome stabilized MALT1 promotes Non-Small Cell Lung Cancer progression through activation of NF-κB pathway
MALT1 has been implicated as an upstream regulator of NF-κB signaling in immune cells and tumors. This study determined the regulatory mechanisms and biological functions of MALT1 in non-small cell lung cancer...
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Deoxynivalenol Detoxification by a Novel Strain of Pichia kudriavzevii via Enzymatic Degradation and Cell Wall Adsorption
Deoxynivalenol (DON) is a mycotoxin that significantly threatens the food and feed industry. Corn steep liquor (CSL) is an acidic byproduct of the corn starch industry, and DON is concentrated in CSL once the ...
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Enhancing petroleum-contaminated soil remediation using pulverized rice straw
This study investigated the effect of pulverized rice straws (PRS, Oryza sativa) on the water retention capacity (WRC) of diesel-contaminated soils and the leaching of diesel-range organics (DROs). Diesel contami...
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Downregulation of SMAD4 protects HaCaT cells against UVB-induced damage and oxidative stress through the activation of EMT
As a member of the SMAD family, SMAD4 plays a crucial role in several cellular biological processes. However, its function in UVB radiation-induced keratinocyte damage is not yet clarified. Our study aims to p...
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Application and Comparison of Different Regression Models in Iodine Balance Experiment on Women of Childbearing Age and Pregnant Women
The iodine balance experiment is a traditional approach to evaluate the physiological requirement for iodine, while the simple linear regression model (SLM) and the mixed effects model (MEM) are two primary me...
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Tissue Accumulation, Cytotoxicity, Oxidative Stress, and Immunotoxicity in African Catfish, Clarias gariepinus Exposed to Sublethal Concentrations of Hexavalent Chromium
Hexavalent chromium (Cr6+) is one of the stable oxidation states of chromium that has been reported to elicit various toxic effects in aquatic organisms. However, the mechanisms of Cr6+ toxicity are still poorly ...
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Multidimensional Transcriptomics Unveils RNF34 as a Prognostic Biomarker and Potential Indicator of Chemotherapy Sensitivity in Wilms’ Tumour
Nephroblastoma, colloquially known as Wilms’ tumour (WT), is the predominant malignant renal neoplasm arising in the paediatric population. Modern therapeutic approaches for WT incorporate a synergistic combin...
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Identification and experimental validation of PYCARD as a crucial PANoptosis-related gene for immune response and inflammation in COPD
Chronic inflammatory and immune responses play key roles in the development and progression of chronic obstructive pulmonary disease (COPD). PANoptosis, as a unique inflammatory cell death modality, is involve...
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Open AccessHepatic Sirt6 activation abrogates acute liver failure
Acute liver failure (ALF) is a deadly illness due to insufficient detoxification in liver induced by drugs, toxins, and other etiologies, and the effective treatment for ALF is very limited. Among the drug-ind...
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An improved CapsNet based on data augmentation for driver vigilance estimation with forehead single-channel EEG
Various studies have shown that it is necessary to estimate the drivers’ vigilance to reduce the occurrence of traffic accidents. Most existing EEG-based vigilance estimation studies have been performed on int...
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Evolution and challenges of opioids in pain management: Understanding mechanisms and exploring strategies for safer analgesics
Opioids traced back to ancient civilizations, have evolved in their usage for acute and chronic pain treatment. Their interaction with the endogenous opioidergic system modulates pain thresholds, neurological ...
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Open AccessThe micro-743a-3p–GSTM1 pathway is an endogenous protective mechanism against alcohol-related liver disease in mice
Epidemiological evidence suggests that the phenotype of glutathione S-transferase mu 1 (GSTM1), a hepatic high-expressed phase II detoxification enzyme, is closely associated with the incidence of alcohol-related...
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Immunogenic Cell Death-related Signature Evaluates the Tumor Microenvironment and Predicts the Prognosis in Diffuse Large B-Cell Lymphoma
Current literatures suggest a growing body of evidence highlighting the pivotal role of Immunogenic Cell Death (ICD) in multiple tumor types. Nevertheless, the potential and mechanisms of ICD in diffuse large ...
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Lateral Habenula Neurons Signal Cold Aversion and Participate in Cold Aversion
The aversion to cold is a fundamental motivated behavior that contributes to the body temperature homeostasis. However, the involvement of the lateral habenula (LHb) as a regulatory hub for negative emotions i...
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Photocatalytic degradation of malachite green based on PW12/MWCNTs/Bi2O3 composite photocatalyst
In this study, Bi2O3 nanoparticles are prepared via an impregnation method and modified using multi-walled carbon nanotubes (MWCNTs) and PW12. XRD reveals that the prepared Bi2O3 corresponded to the monoclinic α-...
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Association of Magnesium, Iron, Copper, and Zinc Levels with the Prevalence of Behavior Problems in Children and Adolescents
Magnesium (Mg), iron (Fe), copper (Cu), and zinc (Zn) are indispensable elements in children’s growth and development. However, epidemiological evidence regarding essential elements and their mixed exposure to...
