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Article
Systematic analysis on the mechanism of Zhizi-Bopi decoction against hepatitis B via network pharmacology and molecular docking
Purpose: Zhizi-Bopi decoction (ZZBPD) is a classic herbal formula with wide clinical applications in treating liver diseases including hepatitis B. However, the mechanism needs to be elucidated.
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Article
Structure and stability analysis of antibacterial substance produced by selenium enriched Bacillus cereus BC1
Microorganisms can produce many antibiotics against bacteria and fungi, which have been used as a potential choice of new antibiotics. In this paper, we studied the characteristics of antibacterial substances by
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Article
Characterization and genomic analysis of a Demerecviridae phage SP76 with lytic multiple-serotypes of Salmonella
With the increase in antimicrobial resistance of Salmonella, phages have been paid more attention to as an alternative to antibiotics. In this study, a phage designated as SP76 was isolated from sewage. It can ly...
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Article
The effectiveness of extended binding affinity of prophage lysin PlyARI against Streptococcus suis infection
Streptococcus suis is an important zoonotic pathogen. An increase in multi-drug-resistant strains has led to poor performance of traditional antibiotic therapies. Thus, alternative antibacterial agents are urgent...
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Article
Efficient production of l-menthyl α-glucopyranoside from l-menthol via whole-cell biotransformation using recombinant Escherichia coli
l-Menthyl α-D-glucopyranoside (α-MenG) is a glycoside derivative of l-menthol with improved water-solubility and new flavor property as a food additive. α-MenG can be synthesized through biotransformation, but it...
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Article
Colorimetric detection of Hg2+ using gold nanoparticles synthesized by Trichosporon montevideense WIN
To investigate a simple, cost-effective and eco-friendly method for colorimetric detection of Hg2+ using gold nanoparticles (AuNPs) synthesized by Trichosporon montevideense WIN.
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Article
Isolation of a fungus Pencicillium sp. with zinc tolerance and its mechanism of resistance
A zinc (Zn)-tolerant fungus, designated BC109-2, was isolated from rhizosphere soil and was identified as Penicillium janthinellum BC109-2 based on ITS sequence analysis. To understand its Zn tolerance mechanisms...
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Article
Open AccessGenomic insights into temperature-dependent transcriptional responses of Kosmotoga olearia, a deep-biosphere bacterium that can grow from 20 to 79 °C
Temperature is one of the defining parameters of an ecological niche. Most organisms thrive within a temperature range that rarely exceeds ~30 °C, but the deep subsurface bacterium Kosmotoga olearia can grow over...
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Article
A systems biology approach to investigate the antimicrobial activity of oleuropein
Oleuropein and its hydrolysis products are olive phenolic compounds that have antimicrobial effects on a variety of pathogens, with the potential to be utilized in food and pharmaceutical products. While the e...
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Article
Real-time quantitative analysis of the influence of blue light on citrinin biosynthetic gene cluster expression in Monascus
When Monascus MX was grown under blue light instead of in the dark, citrinin production increased from 478 mg l−1 to 698 mg l−1. To explain this, the expression of the pksCT gene, which encodes citrinin polyketid...
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Article
Mesotoga prima gen. nov., sp. nov., the first described mesophilic species of the Thermotogales
A novel mesophilic member of the Thermotogales, strain MesG1.Ag.4.2, was isolated from sediments from Baltimore Harbor, MD, USA. The strain grew optimally at 37 °C with a doubling time of 16.5 h on xylose. Car...
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Article
Analysis of unculturable bacterial communities in tea orchard soils based on nested PCR-DGGE
The bacterial communities in the soils from tea orchards and their adjacent wasteland in Anhui Province, China were analysed by nested PCR-DGGE technique combined with sequencing. DGGE profiles revealed that t...
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Article
In vitro study of alginate–chitosan microcapsules: an alternative to liver cell transplants for the treatment of liver failure
The application of alginate–chitosan (AC) microcapsules to liver cell transplantation has not been previously investigated. In the current in vitro study, we have investigated the potential of AC microcapsules fo...
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Article
Stability of microbial lipase in alcoholysis of fish oil during repeated enzyme use
The applications of enzymatic alcoholysis of cod liver oil for preparing omega-3 polyunsaturated fatty acid was investigated. Lipase CES and lipase PS-10 from Pseudomonas sp. catalyzed the alcoholysis of fish oil...