63 Result(s)

Article

Critical roles of tubular mitochondrial ATP synthase dysfunction in maleic acid-induced acute kidney injury

Maleic acid (MA) induces renal tubular cell dysfunction directed to acute kidney injury (AKI). AKI is an increasing global health burden due to its association with mortality and morbidity. However, targeted t...

Hugo Y.-H. Lin, Chan-Jung Liang, Ming-Yu Yang, Phang-Lang Chen, Tzu-Ming Wang… in Apoptosis (2024)

Article

Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift

RNA-based fluorogenic modules have revolutionized the spatiotemporal localization of RNA molecules. Recently, a fluorophore named 5-((Z)-4-((2-hydroxyethyl)(methyl)amino)benzylidene)-3-methyl-2-((E)-styryl)-3,5-d...

Kaiyi Huang, Qianqian Song, Mengyue Fang, Deqiang Yao, **n Shen… in Nature Chemical Biology (2024)

Article

XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...

Qiu-Zhong Pan, **g-**g Zhao, Liang Liu… in Signal Transduction and Targeted Therapy (2024)

Article

cGAS-STING pathway mediates activation of dendritic cell sensing of immunogenic tumors

Type I interferons (IFN-I) play pivotal roles in tumor therapy for three decades, underscoring the critical importance of maintaining the integrity of the IFN-1 signaling pathway in radiotherapy, chemotherapy,...

Guohao Li, **angqian Zhao, Zuda Zheng… in Cellular and Molecular Life Sciences (2024)

Article

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases, which continuously pose one of the most serious threats to human health, attributed to factor...

Yu**g Huang, **aohan Guo, Yi Wu, **ngyu Chen… in Signal Transduction and Targeted Therapy (2024)

Article

Silencing circSERPINE2 restrains mesenchymal stem cell senescence via the YBX3/PCNA/p21 axis

Increasing evidence indicates that circular RNAs (circRNAs) accumulate in aging tissues and nonproliferating cells due to their high stability. However, whether upregulation of circRNA expression mediates stem...

Fenglei Chen, Shan Wang, Chenying Zeng, Su’an Tang… in Cellular and Molecular Life Sciences (2023)

Article

Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery

Crosstalk between the aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling is called the “AhR–Nrf2 gene battery”, which works synergistically in detoxification to su...

Kenly Wuputra, Ming-Ho Tsai, Kohsuke Kato, Chia-Chen Ku… in Inflammation and Regeneration (2023)

Article

Retraction Note: Polydatin improves osteogenic differentiation of human bone mesenchymal stem cells by stimulating TAZ expression via BMP2-Wnt/β-catenin signaling pathway

Ying-Shan Shen, **ao-Jun Chen, Sha-Na Wuri, Fan Yang… in Stem Cell Research & Therapy (2023)

Article

Propofol inhibits myocardial injury induced by microvesicles derived from hypoxia-reoxygenated endothelial cells via lncCCT4-2/CCT4 signaling

Ischemia-reperfusion (IR) induces increased release of extracellular vesicles in the heart and exacerbates myocardial IR injury. We have previously shown that propofol attenuates hypoxia/reoxygenation (HR)-ind...

**aojun Zhang, Changsen Wang, Hao Xu, Shuyun Cai, Keyu Liu… in Biological Research (2023)

Article

Nucleic acid drug vectors for diagnosis and treatment of brain diseases

Nucleic acid drugs have the advantages of rich target selection, simple in design, good and enduring effect. They have been demonstrated to have irreplaceable superiority in brain disease treatment, while vect...

Zhi-Guo Lu, Jie Shen, Jun Yang, **g-Wen Wang… in Signal Transduction and Targeted Therapy (2023)

Article

PKM2 deficiency exacerbates gram-negative sepsis-induced cardiomyopathy via disrupting cardiac calcium homeostasis

Sepsis is a life-threatening syndrome with multi-organ dysfunction in critical care medicine. With the occurrence of sepsis-induced cardiomyopathy (SIC), characterized by reduced ventricular contractility, the...

Le Ni, Bowen Lin, Meiting Shen, Can Li, Lingjie Hu, Fengmei Fu… in Cell Death Discovery (2022)

Article

LIGHT deficiency attenuates acute kidney disease development in an in vivo experimental renal ischemia and reperfusion injury model

Ischemia-reperfusion (I/R), a leading risk factor of acute kidney injury (AKI), is associated with high mortality and risk of progression to chronic kidney disease. However, the molecular mechanism of I/R-AKI ...

Quan-you Zheng, You Li, Shen-ju Liang, **-ming Chen, Ming Tang… in Cell Death Discovery (2022)

Article

Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation

Finely tuned mitogen-activated protein kinase (MAPK) signaling is important for cancer cell survival. Perturbations that push cells out of the MAPK fitness zone result in cell death. Previously, in a screen of...

Guan-Nan Li, Xue-Jiao Zhao, Zhen Wang… in Signal Transduction and Targeted Therapy (2022)

Article

Tripartite motif 25 ameliorates doxorubicin-induced cardiotoxicity by degrading p85α

Doxorubicin (DOX)-based chemotherapy is widely used to treat malignant tumors; however, the cardiotoxicity induced by DOX restricts its clinical usage. A therapeutic dose of DOX can activate ubiquitin-proteaso...

Yihui Shen, Hui Zhang, Yangyue Ni, Xuejun Wang, Yifan Chen… in Cell Death & Disease (2022)

Article

Furin extracellularly cleaves secreted PTENα/β to generate C-terminal fragment with a tumor-suppressive role

PTENα and PTENβ (PTENα/β), two long translational variants of phosphatase and tensin homolog on chromosome 10 (PTEN), exert distinct roles from canonical PTEN, including promoting carcinogenesis and accelerati...

Cheng Zhang, Hong-Ming Ma, Shuang-Shu Dong, Na Zhang, ** He… in Cell Death & Disease (2022)