34 Result(s)
within
Science, Humanities and Social Sciences, multidisciplinary
Science, multidisciplinary
**n-Yue Yan
Article
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Article
Open AccessUnique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing
Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage and jaundice. In more severe cases, massive pul...
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Open AccessMetagenomic analysis of the pinewood nematode microbiome reveals a symbiotic relationship critical for xenobiotics degradation
Our recent research revealed that pinewood nematode (PWN) possesses few genes encoding enzymes for degrading α-pinene, which is the main compound in pine resin. In this study, we examined the role of PWN micro...
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IKKα restoration via EZH2 suppression induces nasopharyngeal carcinoma differentiation
Lack of cellular differentiation is a key feature of nasopharyngeal carcinoma (NPC), but it also presents as a unique opportunity for intervention by differentiation therapy. Here using RNA-seq profiling analy...
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Open AccessGossypium barbadense genome sequence provides insight into the evolution of extra-long staple fiber and specialized metabolites
Of the two cultivated species of allopolyploid cotton, Gossypium barbadense produces extra-long fibers for the production of superior textiles. We sequenced its genome (AD)2 and performed a comparative analysis. ...
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Open AccessIdentification of novel PKD1 and PKD2 mutations in a Chinese population with autosomal dominant polycystic kidney disease
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most frequently inherited renal diseases caused by mutations in PKD1 and PKD2. We performed mutational analyses of PKD genes in 49 unrelated pati...
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Open AccessAn outbreak caused by GII.17 norovirus with a wide spectrum of HBGA-associated susceptibility
During the past norovirus (NoV) epidemic season, a new GII.17 variant emerged as a predominant NoV strain, surpassed the GII.4 NoVs, causing outbreaks of acute gastroenteritis (AGE) in China. Here we report a ...
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Open AccessNaturally occurring proteinaceous nanoparticles in Coptidis Rhizoma extract act as concentration-dependent carriers that facilitate berberine absorption
Pharmacological activities of some natural products diminish and even disappear after purification. In this study, we explored the mechanisms underlying the decrease of acute oral toxicity of Coptidis Rhizoma ext...
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Open AccessCorrection: Corrigendum: Identification of novel PKD1 and PKD2 mutations in a Chinese population with autosomal dominant polycystic kidney disease
Scientific Reports 5: Article number: 17468; published online: 03 December 2015; updated: 23 February 2016 This Article contains typographical errors in Table 2. For Family No. 19, the cDNA change ‘c.8795_8796...
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Open AccessAstragaloside IV improves lipid metabolism in obese mice by alleviation of leptin resistance and regulation of thermogenic network
Obesity is a worldwide threat to public health in modern society, which may result from leptin resistance and disorder of thermogenesis. The present study investigated whether astragaloside IV (ASI) could prev...
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Open AccessOral CoQ10 attenuates high salt-induced hypertension by restoring neurotransmitters and cytokines in the hypothalamic paraventricular nucleus
High salt intake leads to an increase in some proinflammatory cytokines and neurotransmitters involved in the pathogenesis of hypertension. The purpose of this work was to know if oral administration of anti-o...
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Open AccessGamma-H2AX upregulation caused by Wip1 deficiency increases depression-related cellular senescence in hippocampus
The PP2C family member Wild-type p53-induced phosphatase 1 (Wip1) critically regulates DNA damage response (DDR) under stressful situations. In the present study, we investigated whether Wip1 expression was in...
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Open AccessIdentification of New Shikonin Derivatives as Antitumor Agents Targeting STAT3 SH2 Domain
Signal transducer and activator of transcription 3 (STAT3) is hyper-activated in diversiform human tumors and has been validated as an attractive therapeutic target. Current research showed that a natural prod...
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Open AccessComplete mitochondrial genomes of Anopheles stephensi and An. dirus and comparative evolutionary mitochondriomics of 50 mosquitoes
To better understand the phylogeny and evolution of mosquitoes, the complete mitochondrial genome (mitogenome) of Anopheles stephensi and An. dirus were sequenced and annotated, and a total of 50 mosquito mitogen...
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Article
Ground-to-satellite quantum teleportation
Quantum teleportation of single-photon qubits from a ground observatory to a satellite in low-Earth orbit via an uplink channel is achieved with a fidelity that is well above the classical limit.
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Open AccessAlleviative effects of fluoxetine on depressive-like behaviors by epigenetic regulation of BDNF gene transcription in mouse model of post-stroke depression
Fluoxetine, one of the selective serotonin reuptake inhibitor (SSRI) antidepressants, has been thought to be effective for treating post-stroke depression (PSD). Recent work has shown that fluoxetine may exert...
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Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin
Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health 1 . Bats have been recognized as one of the most important reservoirs for emerging v...
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Open AccessMechanisms of wheat (Triticum aestivum) grain storage proteins in response to nitrogen application and its impacts on processing quality
Basis for the effects of nitrogen (N) on wheat grain storage proteins (GSPs) and on the establishment of processing quality are far from clear. The response of GSPs and processing quality parameters to four N ...
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Open AccessGenetic map construction and QTL analysis of leaf-related traits in soybean under monoculture and relay intercrop**
Soybean (Glycine max L.) is an important food and oil crop widely planted by intercrop** in southwest China. The shade caused by intercrop** changes plant growth traits, such as soybean leaf and dry mass, the...
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Open AccessG-CSF Inhibits Pulmonary Fibrosis by Promoting BMSC Homing to the Lungs via SDF-1/CXCR4 Chemotaxis
Bone marrow mesenchymal stem cells (BMSCs) have multi-lineage differentiation potential and play an important role in tissue repair. Studies have shown that BMSCs gather at the injured tissue site after granul...
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Open AccessGenome-wide identification and characterization of DCL, AGO and RDR gene families in Saccharum spontaneum
RNA silencing is a conserved mechanism in eukaryotic organisms to regulate gene expression. Argonaute (AGO), Dicer-like (DCL) and RNA-dependent RNA polymerase (RDR) proteins are critical components of RNA sile...
