773 Result(s)
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Article
Open AccessA review on the thermochemical reaction mechanisms for distiller pyrolysis process
Circular utilization of distillery byproducts is crucial, and pyrolysis has emerged as a viable technology for converting them into fuels and high-value chemicals. This review investigates the thermochemical r...
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Open AccessSingle-cell atlas of the human brain vasculature across development, adulthood and disease
A broad range of brain pathologies critically relies on the vasculature, and cerebrovascular disease is a leading cause of death worldwide. However, the cellular and molecular architecture of the human brain v...
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Open AccessTaqTth-hpRNA: a novel compact RNA-targeting tool for specific silencing of pathogenic mRNA
Pathogenic allele silencing is a promising treatment for genetic hereditary diseases. Here, we develop an RNA-cleaving tool, TaqTth-hpRNA, consisting of a small, chimeric TaqTth, and a hairpin RNA guiding prob...
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Open AccessHumid heat environment causes anxiety-like disorder via impairing gut microbiota and bile acid metabolism in mice
Climate and environmental changes threaten human mental health, but the impacts of specific environmental conditions on neuropsychiatric disorders remain largely unclear. Here, we show the impact of a humid he...
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Open AccessAnalysis of tumor microenvironment alterations in partially responsive rectal cancer patients treated with neoadjuvant chemoradiotherapy
Achieving a pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (NCRT) remains a challenge for most patients with rectal cancer. Exploring the potential of combining NCRT with immunotherapy ...
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Open AccessThe effect of biochar on crop productivity and soil salinity and its dependence on experimental conditions in salt-affected soils: a meta-analysis
Biochar can significantly alter soil properties and therefore can play an important role in increasing the resilience of agricultural systems to salt conditions. To match biochar to salt-affected soil constrai...
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Open AccessCold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy
Recently, environmental temperature has been shown to regulate bone homeostasis. However, the mechanisms by which cold exposure affects bone mass remain unclear. In our present study, we observed that exposure...
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Open AccessCXCR7 activation evokes the anti-PD-L1 antibody against glioblastoma by remodeling CXCL12-mediated immunity
The interaction between glioblastoma cells and glioblastoma-associated macrophages (GAMs) influences the immunosuppressive tumor microenvironment, leading to ineffective immunotherapies. We hypothesized that d...
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Open AccessMicrogels for Cell Delivery in Tissue Engineering and Regenerative Medicine
This review provides a comprehensive summary associated with recent progress in the preparation and application of microgels.
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Open AccessResilient, environment tolerant and biocompatible electroluminescent devices with enhanced luminance based on compliant and self-adhesive electrodes
Electroluminescent (EL) devices are of great significance for expanding the application range of optoelectronics. However, the realization of EL devices with environment-tolerance, stretchability, mechanical c...
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Open AccessHigh SARS-CoV-2 infection rate in children unvaccinated with COVID-19 vaccine in Changzhou, China, shortly after lifting zero-COVID-19 policy in December 2022
China experienced an overwhelming COVID-19 pandemic from middle December 2022 to middle January 2023 after lifting the zero-COVID-19 policy on December 7, 2022. However, the infection rate was less studied. We...
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Open AccessEffect of interpregnancy interval on the risk of gestational diabetes mellitus during a second pregnancy
Interpregnancy interval (IPI) is associated with the risk of GDM in a second pregnancy. However, an optimal IPI is still need to be determined based on the characteristics of the population. This study aimed t...
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Open AccessMaternal BMI changes from the prepregnancy to postpartum period are associated with postpartum cardiometabolic risk factors: a longitudinal study
This study aimed at investigating the associations between the total body mass index (BMI) change at 3 or 4 years postpartum compared to the prepregnancy and cardiometabolic risk factors.
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An efficient memory reserving-and-fading strategy for vector quantization based 3D brain segmentation and tumor extraction using an unsupervised deep learning network
Deep learning networks are state-of-the-art approaches for 3D brain image segmentation, and the radiological characteristics extracted from tumors are of great significance for clinical diagnosis, treatment pl...
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Open AccessCirculating small extracellular vesicles mediate vascular hyperpermeability in diabetes
A hallmark chronic complication of type 2 diabetes mellitus is vascular hyperpermeability, which encompasses dysfunction of the cerebrovascular endothelium and the subsequent development of associated cognitiv...
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Open AccessAssessing intrinsic capacity in Taiwan: Initial psychometric properties of the Integrated Care for Older People Screening Tool for Taiwanese (ICOPES-TW)
The World Health Organization (WHO) proposed the concept of intrinsic capacity (comprising composite physical and mental capacity) which aligns with their concepts of healthy aging and functional ability. Cons...
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Open AccessCausal relationship between resting-state networks and depression: a bidirectional two-sample mendelian randomization study
Cerebral resting-state networks were suggested to be strongly associated with depressive disorders. However, the causal relationship between cerebral networks and depressive disorders remains controversial. In...
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Open AccessApplication of Delaunay adaptive mesh refinement in flood risk assessment of multi-bridge system with short distance
To ensure bridge safety, the flood risk analysis is significant important. However, due to the small size and large number of piers in the short-distance multi-bridge system, the extremely long calculation tim...
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Open AccessEarly-life tobacco smoke exposure and stroke risk: a prospective study of 341,783 and 352,737 UK Biobank participants
Stroke is a life-threatening condition that causes a major medical burden globally. The currently used methods for the prevention or prediction of stroke have certain limitations. Exposure to tobacco in early ...
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Open AccessExploring the mechanism of dendrobine in treating metabolic associated fatty liver disease based on network pharmacology and experimental validation
This study investigates the therapeutic mechanisms of dendrobine, a primary bioactive compound in Dendrobium nobile, for Metabolic Associated Fatty Liver Disease (MASLD) management. Utilizing network pharmacol...
