2,016 Result(s)
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Pharmacokinetics of nirmatrelvir/ritonavir and the drug-drug interaction with calcineurin inhibitor in renal transplant recipients
To describe the pharmacokinetic (PK) characteristics of nirmatrelvir/ritonavir in renal transplant recipients and explore the potential factors that related to the PK variance of nirmatrelvir/ritonavir and its...
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Open AccessA review on the thermochemical reaction mechanisms for distiller pyrolysis process
Circular utilization of distillery byproducts is crucial, and pyrolysis has emerged as a viable technology for converting them into fuels and high-value chemicals. This review investigates the thermochemical r...
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Open AccessSingle-cell atlas of the human brain vasculature across development, adulthood and disease
A broad range of brain pathologies critically relies on the vasculature, and cerebrovascular disease is a leading cause of death worldwide. However, the cellular and molecular architecture of the human brain v...
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Evaluation of fragility fracture risk using deep learning based on ultrasound radio frequency signal
It was essential to identify individuals at high risk of fragility fracture and prevented them due to the significant morbidity, mortality, and economic burden associated with fragility fracture. The quantitat...
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Open AccessTaqTth-hpRNA: a novel compact RNA-targeting tool for specific silencing of pathogenic mRNA
Pathogenic allele silencing is a promising treatment for genetic hereditary diseases. Here, we develop an RNA-cleaving tool, TaqTth-hpRNA, consisting of a small, chimeric TaqTth, and a hairpin RNA guiding prob...
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Open AccessHumid heat environment causes anxiety-like disorder via impairing gut microbiota and bile acid metabolism in mice
Climate and environmental changes threaten human mental health, but the impacts of specific environmental conditions on neuropsychiatric disorders remain largely unclear. Here, we show the impact of a humid he...
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Remediation of phenanthrene contaminated soil by persulphate coupled with Pseudomonas aeruginosa GZ7 based on oxidation prediction model
Chemical oxidation coupled with microbial remediation has attracted widespread attention for the removal of polycyclic aromatic hydrocarbons (PAHs). Among them, the precise evaluation of the feasible oxidant c...
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The Effect of Sintering Temperature on the Microstructure and Electrical Properties of ZnO–Bi2O3 Varistor Ceramics
The effect of sintering temperature on the microstructure and electrical properties of ZnO–Bi2O3 varistor ceramics was studied in the present work. Results demonstrate that the Bi-rich phase ZnBi38O60 is generate...
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Cytokines-activated nuclear IKKα-FAT10 pathway induces breast cancer tamoxifen-resistance
Endocrine therapy that blocks estrogen signaling is the most effective treatment for patients with estrogen receptor positive (ER+) breast cancer. However, the efficacy of agents such as tamoxifen (Tam) is often ...
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Open AccessAnalysis of tumor microenvironment alterations in partially responsive rectal cancer patients treated with neoadjuvant chemoradiotherapy
Achieving a pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (NCRT) remains a challenge for most patients with rectal cancer. Exploring the potential of combining NCRT with immunotherapy ...
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Open AccessThe effect of biochar on crop productivity and soil salinity and its dependence on experimental conditions in salt-affected soils: a meta-analysis
Biochar can significantly alter soil properties and therefore can play an important role in increasing the resilience of agricultural systems to salt conditions. To match biochar to salt-affected soil constrai...
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Comparing Mechanical and Oxidation Properties of Cr- and Si-Alloyed Press-Hardened Steel with 22MnB5 Steel at Various Heating Temperatures
High-performance press-hardened steels (PHS) are highly desired in automotive body-in-white due to their excellent strength and crashworthiness. PHS alloyed with high Cr and Si show promise in enhancing oxidat...
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Open AccessCold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy
Recently, environmental temperature has been shown to regulate bone homeostasis. However, the mechanisms by which cold exposure affects bone mass remain unclear. In our present study, we observed that exposure...
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Update on lacrimal apparatus dysfunction associated with differentiated thyroid cancer after I-131 therapy
The most prevalent lacrimal apparatus dysfunctions associated with differentiated thyroid cancer(DTC) after I-131 therapy are dry eye and nasolacrimal duct obstruction(NLDO), leading to ocular discomfort and l...
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Marine aquaculture can deliver 40% lower carbon footprints than freshwater aquaculture based on feed, energy and biogeochemical cycles
Freshwater aquaculture is an increasingly important source of blue foods but produces substantial methane and nitrous oxide emissions. Marine aquaculture, also known as mariculture, is a smaller sector with a ...
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Utilization of novel bubbling device for continuous measurement of radon in water
Radon can move freely through air and water. Water radon measurement is a method of earthquake monitoring and water radon can be used as an environmental tracer to follow transit pathways. A novel bubbling dev...
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Open AccessCXCR7 activation evokes the anti-PD-L1 antibody against glioblastoma by remodeling CXCL12-mediated immunity
The interaction between glioblastoma cells and glioblastoma-associated macrophages (GAMs) influences the immunosuppressive tumor microenvironment, leading to ineffective immunotherapies. We hypothesized that d...
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Microwave excited hyperthermy and catalysis of heterostructured Au/Cu–BTA for effective bacteria killing by accelerating charge separation
Deep tissue infections caused by pathogenic bacteria seriously threat the lives of patients. In this study, a smart heterostructured Au/Cu–BTA (BTA = 1,2,4,5-benzenetetramine) with microwave (MW) response is s...
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Gender and Age Differences in the Evaluation and Clinical Outcomes of Patients with Palpitations
Palpitations represent a common clinic complaint.
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Open AccessMicrogels for Cell Delivery in Tissue Engineering and Regenerative Medicine
This review provides a comprehensive summary associated with recent progress in the preparation and application of microgels.
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