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936 Result(s)
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Article
Nuclear pseudogenes of mitochondrial DNA as a variable part of the human genome
Novel pseudogenes homologous to the mitochondrial (mt) 16S rRNA gene were detected via different approaches. Eight pseudogenes were sequenced. Copy number polymorphism of the mtDNA pseudogenes was observed amo...
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Cloning and characterization of a novel gene (C17orf25) from the deletion region on chromosome 17p13.3 in hepatocelular carcinoma
Using a combination of hybridization of PAC to a cDNA library and RACE technique, we isolated a novel cDNA, designated as C17orf25 (Chromosome 17 open reading frame 25, previously named it HC71A), from the del...
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Isolation of a choline monooxygenase cDNA clone from Amaranthus tricolor and its expressions under stress conditions
Plants synthesize the osmoprotectant glycine betaine (GB) via choline→ betaine aldehyde→glycine betaine1. Two enzymes are involved in the pathway, choline monooxygenase (CMO) and betaine aldehyde dehydrogenase (B...
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Article
The intracellular mechanism of alpha-fetoprotein promoting the proliferation of NIH 3T3 cells
AIM The existence and properties of alpha-fetoprotein (AFP) receptor on the surface of NIH 3T3 cells and the effects of AFP on cellular signal transduction pathway were investigated. METHODS The effect of AFP ...
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Open AccessA novel link between the proteasome pathway and the signal transduction pathway of the Bone Morphogenetic Proteins (BMPs)
The intracellular signaling events of the Bone Morphogenetic Proteins (BMPs) involve the R-Smad family members Smad1, Smad5, Smad8 and the Co-Smad, Smad4. Smads are currently considered to be DNA-binding trans...
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Article
Negative regulation of TGF-β signaling in development
The TGF-β superfamily members have important roles in controlling patterning and tissue formation in both invertebrates and vertebrates. Two types of signal transducers, receptors and Smads, mediate the signal...
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A novel in vitro system for gamete fusion in maize
Various systems by using electric pulse, calcium, or polyethylene glycol have been developed in the past decade for the in vitro fusion of plant gametes. These in vitro systems provide a new way to study the fert...
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Characterization of candidate class A, B and E floral homeotic genes from the perianthless basal angiosperm Chloranthus spicatus (Chloranthaceae)
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Schistosoma japonicum: The design and experimental evaluation of a multivalent DNA vaccine
The aim of this study was to construct and evaluate the immunity efficacy of the DNA multivalent vaccine pVIVO2SjFABP-23. The vaccine was constructed and produced as follows. Forty BALB/c mice were divided into f...
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Article
Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin
LRP16 was previously identified as an estrogen-induced gene in breast cancer cells. The responsiveness of LRP16 to estrogen and its functional effects in endometrial cancer (EC) cells are still unclear. Here, we ...
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Article
Oncoprotein p28GANK binds to RelA and retains NF-κB in the cytoplasm through nuclear export
p28GANK (also known as PSMD10, p28 and gankyrin) is an ankyrin repeat anti-apoptotic oncoprotein that is commonly overexpressed in hepatocellular carcinomas and increases the degradation of p53 and Rb. NF-κB (nuc...
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The Arabidopsis MutS homolog AtMSH5 is required for normal meiosis
MSH5, a member of the MutS homolog DNA mismatch repair protein family, has been shown to be required for proper homologous chromosome recombination in diverse organisms such as mouse, budding yeast and Caenorhabd...
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An EAL domain protein and cyclic AMP contribute to the interaction between the two quorum sensing systems in Escherichia coli
Quorum sensing (QS) is a bacterial cell-cell communication process by which bacteria communicate using extracellular signals called autoinducers. Two QS systems have been identified in Escherichia coli K-12, incl...
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RNF13: a novel RING-type ubiquitin ligase over-expressed in pancreatic cancer
Protein ubiquitination by E3 ubiquitin ligases plays an important role in cancer development. In this study, we provide experimental evidence that a RING-finger-containing protein RNF13 is an ER/Golgi membrane...
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Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells
Human pluripotent stem cells represent a potentially unlimited source of functional pancreatic endocrine lineage cells. Here we report a highly efficient approach to induce human embryonic stem (ES) cells and ...
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The TAK1-JNK cascade is required for IRF3 function in the innate immune response
Interferon regulatory factor (IRF)3 is critical for the transcriptional induction of chemokines and cytokines during viral or bacterial invasion. The kinases Tank binding kinase (TBK)1 and Ikappa B kinase (IKK...
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Open AccessImproved long-term expression from helper virus-free HSV-1 vectors packaged using combinations of mutated HSV-1 proteins that include the UL13 protein kinase and specific components of the VP16 transcriptional complex
Herpes Simplex Virus (HSV-1) gene expression is thought to shut off recombinant gene expression from HSV-1 vectors; however, in a helper virus-free HSV-1 vector system, a number of promoters support only short...
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Ag nanoparticles sensitize IR-induced killing of cancer cells
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Erratum: Identification of chromosome sequence motifs that mediate meiotic pairing and synapsis in C. elegans
Nature Cell Biol. 11, 934–942 (2009) In the version of this article initially published online and in print, the labelling of Fig 1e was incorrect. The correct version of this figure is shown below. This error...
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Open AccessPreliminary molecular characterization of the human pathogen Angiostrongylus cantonensis
Human angiostrongyliasis is an emerging food-borne public health problem, with the number of cases increasing worldwide, especially in mainland China. Angiostrongylus cantonensis is the causative agent of this se...