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Article
Open AccessSelf-assembled nanoparticles of costunolide and glycyrrhizic acid for enhanced ulcerative colitis treatment
Ulcerative colitis (UC) is a persistent inflammatory condition that specifically targets the colon and rectum. Existing therapies fail to adequately address the clinical requirements of people suffering from t...
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Article
Open AccessCellular metabolism regulates the differentiation and function of T-cell subsets
T cells are an important component of adaptive immunity and protect the host from infectious diseases and cancers. However, uncontrolled T cell immunity may cause autoimmune disorders. In both situations, anti...
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Article
Open AccessHygrothermal stress increases malignant arrhythmias susceptibility by inhibiting the LKB1-AMPK-Cx43 pathway
High mortality due to hygrothermal stress during heat waves is mostly linked to cardiovascular malfunction, the most serious of which are malignant arrhythmias. However, the mechanism associated with hygrother...
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Article
Open AccessLarge-scale comparison of machine learning methods for profiling prediction of kinase inhibitors
Conventional machine learning (ML) and deep learning (DL) play a key role in the selectivity prediction of kinase inhibitors. A number of models based on available datasets can be used to predict the kinase pr...
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Article
Open AccessPerformance of node reporting and data system (node-RADS): a preliminary study in cervical cancer
Node Reporting and Data System (Node-RADS) was proposed and can be applied to lymph nodes (LNs) across all anatomical sites. This study aimed to investigate the diagnostic performance of Node-RADS in cervical ...
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Article
Open AccessThe prognostic value of radiological and pathological lymph node status in patients with cervical cancer who underwent neoadjuvant chemotherapy and followed hysterectomy
To investigate the prognostic value of lymph node status in patients with cervical cancer (CC) patients who underwent neoadjuvant chemotherapy (NACT) and followed hysterectomy. Patients in two referral centers...
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Article
Open AccessRUNX1 targeting AKT3 promotes alveolar hypercoagulation and fibrinolytic inhibition in LPS induced ARDS
Alveolar hypercoagulation and fibrinolytic inhibition are mainly responsible for massive alveolar fibrin deposition, which are closely related with refractory hypoxemia in acute respiratory distress syndrome (...
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Article
Open AccessFrost hardiness of Finnish plus tree progenies of Scots pine from seed orchards in Finland and Ukraine
To avoid the surrounding pollination, seed orchards of Finnish plus trees have been established in Ukraine, i.e., far from their natural distribution. However, it is unknown whether the pollination site affect...
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Article
Open AccessThe malate shuttle detoxifies ammonia in exhausted T cells by producing 2-ketoglutarate
The malate shuttle is traditionally understood to maintain NAD+/NADH balance between the cytosol and mitochondria. Whether the malate shuttle has additional functions is unclear. Here we show that chronic viral i...
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Article
Open AccessField investigation combined with modeling uncovers the ecological heterogeneity of Aedes albopictus habitats for strategically improving systematic management during urbanization
Aedes albopictus is an invasive vector of serious Aedes-borne diseases of global concern. Habitat management remains a critical factor for establishing a cost-effective systematic strategy for sustainable vector ...
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Article
Open AccessRisk prediction for liver injury in Epstein-Barr virus infection in pediatric respiratory tract infections
Epstein-Barr virus (EBV) infection is likely to co-occur in pediatric respiratory tract infections (RTIs). Liver injury is the common complication of EBV infection. The detailed risk factors for liver injury i...
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Article
Open AccessAssociation of body fat and muscle tissue parameters with fatty liver disease identified by ultrasound
To examine the association between body fat and muscle parameters and FLD in individuals of Chinese descent.
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Article
Open AccessThe prognostic nutritional index predicts all-cause mortality in critically ill patients with acute myocardial infarction
Malnutrition is common in patients with acute myocardial infarction (AMI) and is associated with a poor prognosis. The prognostic value of the prognostic nutritional index (PNI) in patients with AMI remains co...
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Article
Open AccessAssociation of depressive symptoms with retirement in Chinese employees: evidence from national longitudinal surveys from 2011 to 2018
The relationship between depressive symptoms and retirement remains controversial. Thus, we aimed to explore the effect of retirement on individuals' depressive symptoms in Chinese employees.
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Article
Open AccessPrognostic impact of in-hospital hemoglobin decline in non-overt bleeding ICU patients with acute myocardial infarction
The prognostic value of in-hospital hemoglobin drop in non-overt bleeding patients with acute myocardial infarction (AMI) admitted to the intensive care unit (ICU) remains insufficiently investigated.
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Article
Open AccessBright Tm3+-based downshifting luminescence nanoprobe operating around 1800 nm for NIR-IIb and c bioimaging
Fluorescence bioimaging based on rare-earth-doped nanocrystals (RENCs) in the shortwave infrared (SWIR, 1000–3000 nm) region has aroused intense interest due to deeper penetration depth and clarity. However, t...
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Article
Open AccessDifferential effects of low and high temperature stress on pollen germination and tube length of mango (Mangifera indica L.) genotypes
Mango flowering is highly sensitive to temperature changes. In this research, the maximum values of pollen germination rate (PGR), pollen tube length (PTL) and their cardinal temperatures (Tmin, Topt and Tmax)...
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Article
Open AccessThe splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis
Pancreatic cancer is characterized by abundant desmoplasia, a dense stroma composed of extra-cellular and cellular components, with cancer associated fibroblasts (CAFs) being the major cellular component. Howe...
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Article
Open AccessAnalysis of CT signs, radiomic features and clinical characteristics for delta variant COVID-19 patients with different vaccination status
To explore the characteristics of peripheral blood, high resolution computed tomography (HRCT) imaging and the radiomics signature (RadScore) in patients infected with delta variant virus under different coron...
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Article
Open AccessEfficacy of ketogenic diet in CDKL5-related epilepsy: a single arm meta-analysis
Drug-resistant epilepsy is one of the most important features of cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder. The ketogenic diet (KD) may be effective for patients with CDKL5-related epilepsy, b...
