34 Result(s)

Article

Multi-modal molecular determinants of clinically relevant osteoporosis subtypes

Due to a rapidly aging global population, osteoporosis and the associated risk of bone fractures have become a wide-spread public health problem. However, osteoporosis is very heterogeneous, and the existing s...

Chunchun Yuan, **ang-Tian Yu, **g Wang, Bing Shu, **ao-Yun Wang… in Cell Discovery (2024)

Article

Droplet-based single-cell joint profiling of histone modifications and transcriptomes

We previously reported Paired-Tag, a combinatorial indexing-based method that can simultaneously map histone modifications and gene expression at single-cell resolution at scale. However, the lengthy procedure...

Yang **e, Chenxu Zhu, Zhaoning Wang… in Nature Structural & Molecular Biology (2023)

Article

Spatial transcriptomics delineates molecular features and cellular plasticity in lung adenocarcinoma progression

Indolent (lepidic) and aggressive (micropapillary, solid, and poorly differentiated acinar) histologic subtypes often coexist within a tumor tissue of lung adenocarcinoma (LUAD), but the molecular features ass...

Yan Wang, Bing Liu, Qingjie Min, **n Yang, Shi Yan, Yuanyuan Ma… in Cell Discovery (2023)

Article

Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia

Aberrant self-renewal of leukemia initiation cells (LICs) drives aggressive acute myeloid leukemia (AML). Here, we report that UHRF1, an epigenetic regulator that recruits DNMT1 to methylate DNA, is highly exp...

Cheng-Long Hu, Bing-Yi Chen, Zijuan Li, Tianbiao Yang, Chun-Hui Xu… in Cell Research (2022)

Article

High-potency PD-1/PD-L1 degradation induced by Peptide-PROTAC in human cancer cells

Meng-Yuan Dai, Yu-Ying Shi, An-** Wang, Xue-Lian Liu, Miao Liu… in Cell Death & Disease (2022)

Article

The Musa troglodytarum L. genome provides insights into the mechanism of non-climacteric behaviour and enrichment of carotenoids

Karat (Musa troglodytarum L.) is an autotriploid Fe’i banana of the Australimusa section. Karat was domesticated independently in the Pacific region, and karat fruit are characterized by a pink sap, a deep yellow...

Zhiying Li, Jiabin Wang, Yunliu Fu, Yonglin **g, Bilan Huang, Ying Chen… in BMC Biology (2022)

Article

DNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0

Paraspeckles are mammal-specific membraneless nuclear bodies that participate in various biological processes. NONO, a central paraspeckle component, has been shown to play pivotal roles in DNA double-strand b...

Yun-Long Wang, Wan-Wen Zhao, Shao-Mei Bai, Yan Ma, **n-Ke Yin… in Cell Death & Disease (2022)

Article

Genome-wide identification and characterization of PdbHLH transcription factors related to anthocyanin biosynthesis in colored-leaf poplar (Populus deltoids)

Basic helix-loop-helix (bHLH) proteins are transcription factors (TFs) that have been shown to regulate anthocyanin biosynthesis in many plant species. However, the bHLH gene family in Populus deltoids has not ye...

**ao-**g Wang, Xu-qian Peng, **ao-chun Shu, Yu-hang Li, Zhong Wang… in BMC Genomics (2022)

Article

Comparative transcriptome and DNA methylation analysis in temperature-sensitive genic male sterile wheat BS366

Known as the prerequisite component for the heterosis breeding system, the male sterile line determines the hybrid yield and seed purity. Therefore, a deep understanding of the mechanism and gene network that ...

Yong-jie Liu, Dan Li, Jie Gong, Yong-bo Wang, Zhao-bo Chen, Bin-shuang Pang… in BMC Genomics (2021)

Article

Corticotropin releasing hormone promotes inflammatory bowel disease via inducing intestinal macrophage autophagy

Psychosocial stress is a vital factor contributing to the pathogenesis and progression of inflammatory bowel disease (IBD). The contribution of intestinal macrophage autophagy to the onset and development of I...

Sheng-Bing Zhao, Jia-Yi Wu, Zi-Xuan He, Yi-Hang Song, **n Chang… in Cell Death Discovery (2021)

Article

Swiprosin-1 deficiency in macrophages alleviated atherogenesis

Macrophages play a vital role in the development of atherosclerosis. Previously, we have found that swiprosin-1 was abundantly expressed in macrophages. Here, we investigated the role of swiprosin-1 expressed ...

Ling-Chang Tong, Zhi-Bin Wang, Jia-Qi Zhang, Yue Wang, Wei-Ye Liu… in Cell Death Discovery (2021)

Article

SREBP1 site 1 protease inhibitor PF-429242 suppresses renal cell carcinoma cell growth

Renal cell carcinoma (RCC) cells have increased lipogenesis and cholesterol synthesis. Sterol regulatory element-binding protein-1 (SREBP1) is cleaved by site 1 protease (S1P) to release the transcriptionally ...

Tong-bing Wang, Mei Geng, Hua **, Ai-guo Tang, Hao Sun… in Cell Death & Disease (2021)

Article

Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury

Compelling evidence has revealed that biased activation of G protein-coupled receptor (GPCR) signaling, including angiotensin II (AngII) receptor type 1 (AT1) signaling, plays pivotal roles in vascular homeost...

Yi Fu, Yaqian Huang, Zhao Yang, Yufei Chen, **gang Zheng, Chenfeng Mao… in Cell Research (2021)

Article

Circ_0008542 in osteoblast exosomes promotes osteoclast-induced bone resorption through m6A methylation

With an increasing aging society, China is the world’s fastest growing markets for oral implants. Compared with traditional oral implants, immediate implants cause marginal bone resorption and increase the fai...

Wei Wang, Shi-Chong Qiao, **ang-Bing Wu, Bao Sun, **-Gang Yang… in Cell Death & Disease (2021)

Article

Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome

Organization of the genome into euchromatin and heterochromatin appears to be evolutionarily conserved and relatively stable during lineage differentiation. In an effort to unravel the basic principle underlyi...

J. Yuyang Lu, Lei Chang, Tong Li, Ting Wang, Yafei Yin, Ge Zhan, Xue Han… in Cell Research (2021)

Article

ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species

Bats are the suggested natural hosts for severe acute respiratory syndrome coronavirus (SARS-CoV) and the causal agent of the coronavirus disease 2019 (COVID-19) pandemic, SARS-CoV-2. The interaction of viral ...

Huan Yan, Hengwu Jiao, Qianyun Liu, Zhen Zhang, Qing **ong… in Nature Ecology & Evolution (2021)

Article

Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis

The bivalent domain (BD) at promoter region is an unique epigenetic feature poised for activation or repression during cell differentiation in embryonic stem cell. However, the function of BDs in already diffe...

Jiahuan Chen, **aodong Liang, Shasha Zhang, Shiyan Wang… in Cell Death & Disease (2020)

Article

Intestinal autophagy links psychosocial stress with gut microbiota to promote inflammatory bowel disease

Psychosocial stress is a critical inducing factor of inflammatory bowel diseases (IBD), while autophagy is a novel central issue of IBD development. The present study investigated the potential role of autopha...

Shu-Ling Wang, Bo-Zong Shao, Sheng-Bing Zhao, **n Chang, Pei Wang… in Cell Death & Disease (2019)

Article

NDRG2 suppression as a molecular hallmark of photoreceptor-specific cell death in the mouse retina

Photoreceptor cell death is recognized as the key pathogenesis of retinal degeneration, but the molecular basis underlying photoreceptor-specific cell loss in retinal damaging conditions is virtually unknown. ...

Cheng-Biao Hu, Bing-Dong Sui, Bao-Ying Wang, Gao Li, Cheng-Hu Hu… in Cell Death Discovery (2018)

Article

Author Correction: Ephrin receptor A2 is an epithelial cell receptor for Epstein–Barr virus entry

In the version of this Letter originally published, the authors reported on the use of 2,5-dimethylpyrrolyl benzoic acid to block Ephrin receptors. In 2011, it was reported that newly synthesized 2,5-dimethylp...

Hua Zhang, Yan Li, Hong-Bo Wang, Ao Zhang, Mei-Ling Chen… in Nature Microbiology (2018)