41 Result(s)
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Article
LncRNA Tug1 relieves the steatosis of SelenoF-knockout hepatocytes via sponging miR-1934-3p
Metabolic dysfunction associated with fatty liver disease (MAFLD), always accompanied by disturbance of glucose and lipid metabolism, is becoming the most difficult obstacle in the next decades. In the current...
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Open AccessDroplet-based single-cell joint profiling of histone modifications and transcriptomes
We previously reported Paired-Tag, a combinatorial indexing-based method that can simultaneously map histone modifications and gene expression at single-cell resolution at scale. However, the lengthy procedure...
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Article
Evolutionary shifts in pheromone receptors contribute to speciation in four Helicoverpa species
Male moths utilize their pheromone communication systems to distinguish potential mates from other sympatric species, which contributes to maintaining reproductive isolation and even drives speciation. The mol...
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Article
Cross-sectional relationships between general and central adiposity and plasma amino acids in Chinese adults
Adiposity is an important determinant of blood metabolites, but little is known about the variations of blood amino acids according to general and central adiposity status among Chinese population. This study ...
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Article
Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction
Membrane dynamics are important to the integrity and function of mitochondria. Defective mitochondrial fusion underlies the pathogenesis of multiple diseases. The ability to target fusion highlights the potent...
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Article
Open AccessHigh-potency PD-1/PD-L1 degradation induced by Peptide-PROTAC in human cancer cells
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Open AccessDNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0
Paraspeckles are mammal-specific membraneless nuclear bodies that participate in various biological processes. NONO, a central paraspeckle component, has been shown to play pivotal roles in DNA double-strand b...
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Haloterrigena gelatinilytica sp. nov., a new extremely halophilic archaeon isolated from salt-lake
Two extremely halophilic strains, designated SYSU A558-1T and SYSU A121-1, were isolated from a saline sediment sample collected from Aiding salt-lake, China. Cells of strains SYSU A558-1T and SYSU A121-1 were Gr...
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Article
Phase separation of RNA-binding protein promotes polymerase binding and transcription
An RNA-involved phase-separation model has been proposed for transcription control. However, the molecular links that connect RNA to the transcription machinery remain missing. Here we find that RNA-binding pr...
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Open AccessCorticotropin releasing hormone promotes inflammatory bowel disease via inducing intestinal macrophage autophagy
Psychosocial stress is a vital factor contributing to the pathogenesis and progression of inflammatory bowel disease (IBD). The contribution of intestinal macrophage autophagy to the onset and development of I...
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Open AccessSwiprosin-1 deficiency in macrophages alleviated atherogenesis
Macrophages play a vital role in the development of atherosclerosis. Previously, we have found that swiprosin-1 was abundantly expressed in macrophages. Here, we investigated the role of swiprosin-1 expressed ...
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Article
Transcriptomic responses of haloalkalitolerant bacterium Egicoccus halophilus EGI 80432T to highly alkaline stress
The haloalkalitolerant bacterium Egicoccus halophilus EGI 80432T exhibits high adaptability to saline–alkaline environment. The salinity adaptation mechanism of E. halophilus EGI 80432T was fully understood based...
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Article
Genetic and molecular characterization of determinant of six-rowed spike of barley carrying vrs1.a4
Decisive role of reduced vrs1 transcript abundance in six-rowed spike of barley carrying vrs1.a4 was genetically proved and its potential causes were preliminarily analyzed.
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Article
Detection of SARS-CoV-2 RNA in Medical Wastewater in Wuhan During the COVID-19 Outbreak
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Article
Open AccessSREBP1 site 1 protease inhibitor PF-429242 suppresses renal cell carcinoma cell growth
Renal cell carcinoma (RCC) cells have increased lipogenesis and cholesterol synthesis. Sterol regulatory element-binding protein-1 (SREBP1) is cleaved by site 1 protease (S1P) to release the transcriptionally ...
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Open AccessCirc_0008542 in osteoblast exosomes promotes osteoclast-induced bone resorption through m6A methylation
With an increasing aging society, China is the world’s fastest growing markets for oral implants. Compared with traditional oral implants, immediate implants cause marginal bone resorption and increase the fai...
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Mitochondria-targeted Re(I) complexes bearing guanidinium as ligands and their anticancer activity
As the “powerhouse” of a cell, mitochondria maintain energy homeostasis, synthesize ATP via oxidative phosphorylation, generate ROS signaling molecules, and modulate cell apoptosis. Herein, three Re(I) complex...
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Article
Recombinant Horseradish Peroxidase C1A Immobilized on Hydrogel Matrix for Dye Decolorization and Its Mechanism on Acid Blue 129 Decolorization
In this study, horseradish peroxidase C1A (HRP C1A) from Armoracia rusticana was expressed in Escherichia coli as an inclusion body. Subsequently, an active recombinant HRP C1A was obtained by refolding gradually...
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Article
Open AccessTwo faces of bivalent domain regulate VEGFA responsiveness and angiogenesis
The bivalent domain (BD) at promoter region is an unique epigenetic feature poised for activation or repression during cell differentiation in embryonic stem cell. However, the function of BDs in already diffe...
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Article
Open AccessIntestinal autophagy links psychosocial stress with gut microbiota to promote inflammatory bowel disease
Psychosocial stress is a critical inducing factor of inflammatory bowel diseases (IBD), while autophagy is a novel central issue of IBD development. The present study investigated the potential role of autopha...
