-
Article
LncRNA Tug1 relieves the steatosis of SelenoF-knockout hepatocytes via sponging miR-1934-3p
Metabolic dysfunction associated with fatty liver disease (MAFLD), always accompanied by disturbance of glucose and lipid metabolism, is becoming the most difficult obstacle in the next decades. In the current...
-
Article
Open AccessDroplet-based single-cell joint profiling of histone modifications and transcriptomes
We previously reported Paired-Tag, a combinatorial indexing-based method that can simultaneously map histone modifications and gene expression at single-cell resolution at scale. However, the lengthy procedure...
-
Article
Evolutionary shifts in pheromone receptors contribute to speciation in four Helicoverpa species
Male moths utilize their pheromone communication systems to distinguish potential mates from other sympatric species, which contributes to maintaining reproductive isolation and even drives speciation. The mol...
-
Article
Cross-sectional relationships between general and central adiposity and plasma amino acids in Chinese adults
Adiposity is an important determinant of blood metabolites, but little is known about the variations of blood amino acids according to general and central adiposity status among Chinese population. This study ...
-
Article
Open AccessHigh-potency PD-1/PD-L1 degradation induced by Peptide-PROTAC in human cancer cells
-
Article
Open AccessDNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0
Paraspeckles are mammal-specific membraneless nuclear bodies that participate in various biological processes. NONO, a central paraspeckle component, has been shown to play pivotal roles in DNA double-strand b...
-
Article
Haloterrigena gelatinilytica sp. nov., a new extremely halophilic archaeon isolated from salt-lake
Two extremely halophilic strains, designated SYSU A558-1T and SYSU A121-1, were isolated from a saline sediment sample collected from Aiding salt-lake, China. Cells of strains SYSU A558-1T and SYSU A121-1 were Gr...
-
Article
Open AccessCorticotropin releasing hormone promotes inflammatory bowel disease via inducing intestinal macrophage autophagy
Psychosocial stress is a vital factor contributing to the pathogenesis and progression of inflammatory bowel disease (IBD). The contribution of intestinal macrophage autophagy to the onset and development of I...
-
Article
Open AccessSwiprosin-1 deficiency in macrophages alleviated atherogenesis
Macrophages play a vital role in the development of atherosclerosis. Previously, we have found that swiprosin-1 was abundantly expressed in macrophages. Here, we investigated the role of swiprosin-1 expressed ...
-
Article
Transcriptomic responses of haloalkalitolerant bacterium Egicoccus halophilus EGI 80432T to highly alkaline stress
The haloalkalitolerant bacterium Egicoccus halophilus EGI 80432T exhibits high adaptability to saline–alkaline environment. The salinity adaptation mechanism of E. halophilus EGI 80432T was fully understood based...
-
Article
Genetic and molecular characterization of determinant of six-rowed spike of barley carrying vrs1.a4
Decisive role of reduced vrs1 transcript abundance in six-rowed spike of barley carrying vrs1.a4 was genetically proved and its potential causes were preliminarily analyzed.
-
Article
Open AccessSREBP1 site 1 protease inhibitor PF-429242 suppresses renal cell carcinoma cell growth
Renal cell carcinoma (RCC) cells have increased lipogenesis and cholesterol synthesis. Sterol regulatory element-binding protein-1 (SREBP1) is cleaved by site 1 protease (S1P) to release the transcriptionally ...
-
Article
Open AccessCirc_0008542 in osteoblast exosomes promotes osteoclast-induced bone resorption through m6A methylation
With an increasing aging society, China is the world’s fastest growing markets for oral implants. Compared with traditional oral implants, immediate implants cause marginal bone resorption and increase the fai...
-
Article
Mitochondria-targeted Re(I) complexes bearing guanidinium as ligands and their anticancer activity
As the “powerhouse” of a cell, mitochondria maintain energy homeostasis, synthesize ATP via oxidative phosphorylation, generate ROS signaling molecules, and modulate cell apoptosis. Herein, three Re(I) complex...
-
Article
Open AccessTwo faces of bivalent domain regulate VEGFA responsiveness and angiogenesis
The bivalent domain (BD) at promoter region is an unique epigenetic feature poised for activation or repression during cell differentiation in embryonic stem cell. However, the function of BDs in already diffe...
-
Article
Open AccessIntestinal autophagy links psychosocial stress with gut microbiota to promote inflammatory bowel disease
Psychosocial stress is a critical inducing factor of inflammatory bowel diseases (IBD), while autophagy is a novel central issue of IBD development. The present study investigated the potential role of autopha...
-
Article
Integrated proteomic and metabolomic analysis of a reconstructed three-species microbial consortium for one-step fermentation of 2-keto-l-gulonic acid, the precursor of vitamin C
Microbial consortia, with the merits of strong stability, robustness, and multi-function, played critical roles in human health, bioenergy, and food manufacture, etc. On the basis of ‘build a consortium to und...
-
Article
Bacterial laccases: promising biological green tools for industrial applications
Multicopper oxidases (MCOs) are a pervasive family of enzymes that oxidize a wide range of phenolic and nonphenolic aromatic substrates, concomitantly with the reduction of dioxygen to water. MCOs are usually ...
-
Article
Open AccessNDRG2 suppression as a molecular hallmark of photoreceptor-specific cell death in the mouse retina
Photoreceptor cell death is recognized as the key pathogenesis of retinal degeneration, but the molecular basis underlying photoreceptor-specific cell loss in retinal damaging conditions is virtually unknown. ...
-
Article
Open AccessParkin regulates NF-κB by mediating site-specific ubiquitination of RIPK1
Parkin (Park2), a RING-between-RING-type E3 ubiquitin ligase, has been implicated in regulating NF-κB. Mutations in Parkin are associated with Parkinson’s disease. Here we investigated the interaction of Parki...