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  1. No Access

    Article

    Analysis of aberrant methylation of the VHL gene by transgenes, monochromosome transfer, and cell fusion

    Several tumor suppressor genes were shown to be inactivated by a process involving aberrant de novo methylation of their GC-rich promoters which is usually associated with transcriptional repression. The mechanis...

    Igor Kuzmin, Laura Geil, Haiyan Ge, Ulla Bengtsson, Fuh-Mei Duh… in Oncogene (1999)

  2. No Access

    Article

    Regulation of the Wilms' tumour suppressor protein transcriptional activation domain

    The Wilms' tumour suppressor protein WT1 contains a transcriptional regulatory domain that can either activate or repress transcription depending upon its cellular environment. The mechanistic basis for this d...

    Lynn M McKay, Brian Carpenter, Stefan GE Roberts in Oncogene (1999)

  3. No Access

    Article

    Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells

    Activation of the neurotrophin receptor TrkA by its ligand nerve growth factor (NGF) initiates a cascade of signaling events leading to neuronal differentiation in vitro and might play an important role in the di...

    Angelika Eggert, Naohiko Ikegaki, **ng-ge Liu, Thomas T Chou, Virginia M Lee… in Oncogene (2000)

  4. No Access

    Article

    Expression of PTEN in PTEN-deficient multiple myeloma cells abolishes tumor growth in vivo

    Biochemical abnormalities associated with the development of multiple myeloma have been difficult to define especially in terms of demonstrating an in vivo effect of suspected lesions. Herein, we have identified ...

    Nie-Lin Ge, Stuart Rudikoff in Oncogene (2000)

  5. No Access

    Article

    The c-Myc-interacting adaptor protein Bin1 activates a caspase-independent cell death program

    Cell death processes are progressively inactivated during malignant development, in part by loss of tumor suppressors that can promote cell death. The Bin1 gene encodes a nucleocytosolic adaptor protein with t...

    Katherine Elliott, Kai Ge, Wei Du, George C Prendergast in Oncogene (2000)

  6. No Access

    Article

    Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma

    In classical Hodgkin lymphoma the malignant Hodgkin/Reed-Sternberg (HRS) cells characteristically constitute only a small minority of the tumour load. Their origin has been debated for decades, but on the basi...

    Christina B Hertel, **ao-ge Zhou, Stephen J Hamilton-Dutoit, Steffen Junker in Oncogene (2002)

  7. No Access

    Article

    Inhibition of AP-1 transcription factor causes blockade of multiple signal transduction pathways and inhibits breast cancer growth

    AP-1 transcription factors play a critical role in signal transduction pathways in many cells. We have investigated the role of AP-1 in controlling proliferative signals in breast cells, and have previously sh...

    Yongmin Liu, John Ludes-Meyers, Yun Zhang, Debbie Munoz-Medellin, Hee-Tae Kim… in Oncogene (2002)

  8. No Access

    Article

    Patterns of expression of chromosome 17 genes in primary cultures of normal ovarian surface epithelia and epithelial ovarian cancer cell lines

    Oligonucleotide microarray analysis was applied to assess the expression profile of 332 probe sets representing 308 genes or expressed sequence tags (ESTs) that map to chromosome 17 in order to address epigene...

    Nadège Presneau, Anne-Marie Mes-Masson, Bing Ge, Diane Provencher… in Oncogene (2003)

  9. No Access

    Article

    Regulation of apoptosis proteins in cancer cells by ubiquitin

    Ubiquitin inhibitors act at many levels to enhance apoptosis signaling. For TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis signaling, there are at least five mechanisms by which apoptosis are...

    Huang-Ge Zhang, Jianhua Wang, **nwen Yang, Hui-Chen Hsu, John D Mountz in Oncogene (2004)

  10. No Access

    Article

    Microarray expression profiling in melanoma reveals a BRAF mutation signature

    We have used microarray gene expression profiling and machine learning to predict the presence of BRAF mutations in a panel of 61 melanoma cell lines. The BRAF gene was found to be mutated in 42 samples (69%) and...

    Sandra Pavey, Peter Johansson, Leisl Packer, Jennifer Taylor, Mitchell Stark… in Oncogene (2004)

  11. No Access

    Article

    Hsp90–Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis

    Hsp90 client protein Akt has been shown to inhibit cell apoptosis in part by inhibiting proapoptotic kinase ASK1 (apoptosis signal-regulating kinase 1) activity. In the present study, we show that Hsp90 inhibi...

    Rong Zhang, Dianhong Luo, Robert Miao, Lanfang Bai, Qingyuan Ge… in Oncogene (2005)

  12. No Access

    Article

    Discrimination between serous low malignant potential and invasive epithelial ovarian tumors using molecular profiling

    Tumors of low malignant potential (LMP) represent 20% of epithelial ovarian cancers (EOCs) and are associated with a better prognosis than the invasive tumors (TOV). Defining the relationship between LMPs and ...

    Véronique Ouellet, Diane M Provencher, Christine M Maugard, Cécile Le Page… in Oncogene (2005)

  13. No Access

    Article

    BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription

    BCL3 is a proto-oncogene affected by chromosomal translocations in some patients with chronic lymphocytic leukemia. It is an IκB family protein that is involved in transcriptional regulation of a number of NF-κB ...

    K Brocke-Heidrich, B Ge, H Cvijic, G Pfeifer, D Löffler, C Henze, T W McKeithan… in Oncogene (2006)

  14. No Access

    Article

    Identification and characterization of novel AML1-ETO fusion transcripts in pediatric t(8;21) acute myeloid leukemia: a report from the Children's Oncology Group

    t(8;21)(q22;q22) results in the AML1-ETO (A1E) fusion gene and is a common cytogenetic abnormality in acute myeloid leukemia (AML). Although insertions at the breakpoint region of the A1E fusion transcripts ha...

    K M LaFiura, H Edwards, J W Taub, L H Matherly, J A Fontana, A N Mohamed… in Oncogene (2008)

  15. No Access

    Article

    Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma

    Chemoresistance is a major cause of treatment failure and poor outcome in neuroblastoma. In this study, we investigated the expression and function of dual-specificity phosphatase 26 (DUSP26), also known as mi...

    X Shang, S A Vasudevan, Y Yu, N Ge, A D Ludwig, C L Wesson, K Wang… in Oncogene (2010)

  16. No Access

    Article

    Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivation

    Here, we report the identification and characterization of a novel tyrosine phosphorylation site in the carboxy-terminal Src Homology 3 (SH3) (SH3C) domain of the Crk adaptor protein. Y251 is located in the hi...

    G Sriram, C Reichman, A Tunceroglu, N Kaushal, T Saleh, K Machida, B Mayer… in Oncogene (2011)

  17. No Access

    Article

    Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop

    Dysregulated microRNAs (miRNAs) have an important role in many malignant tumors. However, elucidating the roles of miRNAs in cancer biology, especially in epithelial cancers, remains an ongoing process. In thi...

    J Zhang, Q Sun, Z Zhang, S Ge, Z-G Han, W-T Chen in Oncogene (2013)

  18. Article

    Open Access

    Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human colorectal carcinoma

    G-protein-coupled receptor 120 (GPR120) functions as a receptor for unsaturated long-chain free fatty acids and has an important role in regulating lipid and glucose metabolism. However, a role for GPR120 in t...

    Q Wu, H Wang, X Zhao, Y Shi, M **, B Wan, H Xu, Y Cheng, H Ge, Y Zhang in Oncogene (2013)

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  19. Article

    Open Access

    Par-4/THAP1 complex and Notch3 competitively regulated pre-mRNA splicing of CCAR1 and affected inversely the survival of T-cell acute lymphoblastic leukemia cells

    Although the intensification of therapy for children with T-cell acute lymphoblastic leukemia (T-ALL) has substantially improved clinical outcomes, T-ALL remains an important challenge in pediatric oncology. H...

    C Lu, J-Y Li, Z Ge, L Zhang, G-P Zhou in Oncogene (2013)

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  20. No Access

    Article

    EphA2 promotes epithelial–mesenchymal transition through the Wnt/β-catenin pathway in gastric cancer cells

    This study aims to investigate the significance of erythropoietin-producing hepatocellular (Eph)A2 expression and the mechanism by which EphA2 is involved in the epithelial–mensenchymal transition (EMT) of gas...

    J Huang, D **ao, G Li, J Ma, P Chen, W Yuan, F Hou, J Ge, M Zhong, Y Tang… in Oncogene (2014)

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