54 Result(s)

Article

Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells

Acute myeloid leukemia (AML) is a serious disease. The 5-year survival rates remain frustratingly low (65% for children and 26% for adults). Resistance to frontline chemotherapy (usually cytarabine) often deve...

Daniel A Luedtke, **aojia Niu, Yihang Pan… in Signal Transduction and Targeted Therapy (2017)

Article

Targeting the CXCR4/CXCL12 axis with the peptide antagonist E5 to inhibit breast tumor progression

Emerging evidence has demonstrated that stromal cell-derived factor 1 (SDF-1) and its cognate receptor CXCR4 have critical roles in tumorigenesis, angiogenesis and metastasis. In this study, we demonstrated th...

Hua Guo, Yangyang Ge, **ao** Li, Yanlian Yang… in Signal Transduction and Targeted Therapy (2017)

Article

Simultaneous cotargeting of ATR and RNA Polymerase I transcription demonstrates synergistic antileukemic effects on acute myeloid leukemia

Tingting Wang, Margaret Shatara, Fangbing Liu… in Signal Transduction and Targeted Therapy (2019)

Article

Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia

Venetoclax, an FDA-approved Bcl-2 selective inhibitor for the treatment of chronic lymphocytic leukemia and acute myeloid leukemia (AML), is tolerated well in elderly patients with AML and has good overall res...

Daniel A. Luedtke, Yongwei Su, Jun Ma, **nyu Li… in Signal Transduction and Targeted Therapy (2020)

Article

Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein

Geng Chen, **ankun Wang, Yunjun Ge, Ling Ma… in Signal Transduction and Targeted Therapy (2020)

Article

Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy

Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the second most common form of acute leukemia in children. Despite this, very little improvement in survival rates has been ...

Jenna L. Carter, Katie Hege, Jay Yang… in Signal Transduction and Targeted Therapy (2020)

Article

STAT3 ameliorates cognitive deficits by positively regulating the expression of NMDARs in a mouse model of FTDP-17

In tauopathies, memory impairment positively strongly correlates with the amount of abnormal tau aggregates; however, how tau accumulation induces synapse impairment is unclear. Recently, we found that human t...

**ao-Yue Hong, Hua-Li Wan, Ting Li… in Signal Transduction and Targeted Therapy (2020)

Article

Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice

In vertebrates, the type 1 parathyroid hormone receptor (PTH1R) is a critical regulator of skeletal development and homeostasis; however, how it is modulated is incompletely understood. Here we report that del...

Xuekun Fu, Bo Zhou, Qinnan Yan, Chu Tao… in Signal Transduction and Targeted Therapy (2020)

Article

Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster

Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness. To experimentally demonstrate the epidemiological results, we performed animal studies to infect male ...

Lunzhi Yuan, Huachen Zhu, Ming Zhou, Jian Ma… in Signal Transduction and Targeted Therapy (2021)

Article

An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19

The global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019 (COVID-19). In this study,...

Yiyue Ge, Tingzhong Tian, Suling Huang… in Signal Transduction and Targeted Therapy (2021)

Article

Metagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-19

COVID-19 remains a serious emerging global health problem, and little is known about the role of oropharynx commensal microbes in infection susceptibility and severity. Here, we present the oropharyngeal micro...

Shengli Ma, Fan Zhang, Fengxia Zhou, Hui Li… in Signal Transduction and Targeted Therapy (2021)

Article

CPSF4 promotes triple negative breast cancer metastasis by upregulating MDM4

Ka** Lee, Qiufan Zheng, Qianyi Lu, Fei Xu… in Signal Transduction and Targeted Therapy (2021)

Article

The arsenal of TP53 mutants therapies: neoantigens and bispecific antibodies

Chang Yang, Ge Lou, Wei-Lin ** in Signal Transduction and Targeted Therapy (2021)

Article

Identification of SARS-CoV-2-against aptamer with high neutralization activity by blocking the RBD domain of spike protein 1

Ge Yang, Ziyue Li, Irfan Mohammed, Li** Zhao… in Signal Transduction and Targeted Therapy (2021)

Article

Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation

The COVID-19 pandemic poses a global threat to public health and economy. The continuously emerging SARS-CoV-2 variants present a major challenge to the development of antiviral agents and vaccines. In this st...

Shuai **a, Qiaoshuai Lan, Yun Zhu, Chao Wang… in Signal Transduction and Targeted Therapy (2021)

Article

Differential immune responses in pregnant patients recovered from COVID-19

Pregnant women are generally more susceptible to viral infection. Although the impact of SARS-CoV-2 in pregnancy remains to be determined, evidence indicates that the risk factors for severe COVID-19 are simil...

Ge Chen, Yiming Zhang, Yaoyao Zhang, Jihui Ai… in Signal Transduction and Targeted Therapy (2021)

Article

m6A demethylase FTO attenuates cardiac dysfunction by regulating glucose uptake and glycolysis in mice with pressure overload-induced heart failure

Beijian Zhang, Hao Jiang, Jian Wu, Yun Cai… in Signal Transduction and Targeted Therapy (2021)

Article

Safety and activity of WX-0593 (Iruplinalkib) in patients with ALK- or ROS1-rearranged advanced non-small cell lung cancer: a phase 1 dose-escalation and dose-expansion trial

WX-0593 (Iruplinalkib) is a novel, highly selective oral ALK and ROS1 tyrosine kinase inhibitor (TKI). In this study, the safety, antitumor activity, and pharmacokinetics of WX-0593 were evaluated in advanced ...

Yuankai Shi, Jian Fang, Xuezhi Hao… in Signal Transduction and Targeted Therapy (2022)

Article

Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury

Spinal cord injury (SCI) involves diverse injury responses in different cell types in a temporally and spatially specific manner. Here, using single-cell transcriptomic analyses combined with classic anatomica...

Chen Li, Zhourui Wu, Liqiang Zhou… in Signal Transduction and Targeted Therapy (2022)

Article

Recombinant human erythropoietin ameliorates cognitive dysfunction of APP/PS1 mice by attenuating neuron apoptosis via HSP90β

Hua-Li Wan, Bing-Ge Zhang, Chongyang Chen… in Signal Transduction and Targeted Therapy (2022)