305 Result(s)
within
English
Life Sciences
Biochemistry, general
Cell Biology
**fa Guan
Article
-
Article
Normal mitochondrial structure and genome maintenance in yeast requires the dynamin-like product of the MGM1 gene
The isolation and characterization of MGM1, and yeast gene with homology to members of the dynamin gene family, is described. The MGM1 gene is located on the right arm of chromosome XV between STE4 and PTP2. Sequ...
-
Article
A new point mutation in the nuclear gene of yeast mitochondrial RNA polymerase, RPO41, identifies a functionally important amino-acid residue in a protein region conserved among mitochondrial core enzymes
The core enzyme of mitochondrial RNA polymerase in yeast is homologous to those of bacteriophages T3, T7 and SP6. In previous studies the identification of the first conditional yeast mutant for this enzyme help...
-
Article
Effects of tumors on inhaled pharmacologic drugs
Lung carcinomas are now the most common form of cancer. Clinical data suggest that tumors are found preferentially in upper airways, perhaps specifically at carina within bifurcations. The disease can be treat...
-
Article
Effects of tumors on inhaled pharmacologic drugs
Computer simulations were conducted to describe drug particle motion in human lung bifurcations with tumors. The computations used FIDAP with a Cray T90 supercomputer. The objective was to better understand pa...
-
Article
Compensatory caspase activation in MPP+-induced cell death in dopaminergic neurons
Many have hypothesized that cell death in Parkinson’s disease is via apoptosis and, specifically, by the mitochondrial-mediated apoptotic pathway. We tested this hypothesis using a mouse dopaminergic cell line...
-
Article
Semaphorins command cells to move
Semaphorins are secreted or transmembrane proteins that mediate repulsive axon guidance, immune cell regulation, and vascular growth and remodelling.
... -
Article
Microtubule breakage is not a major mechanism for resolving end-to-end chromosome fusions generated by telomere dysfunction during the early process of immortalization
Telomeres, the terminal chromosomal structure crucial for maintaining genomic integrity, shorten with deoxyribonucleic acid replications in most human somatic cells. Chromosomes carrying critically short telom...
-
Article
Proteomics in nasopharyngeal carcinoma
-
Article
Ultrasound enhanced methanol penetration of zebrafish (Danio rerio) embryos measured by permittivity changes using impedance spectroscopy
Studies on permittivity changes in fish embryos measured by impedance spectroscopy after ultrasound treatment during exposure to cryoprotectant is reported here for the first time. The permittivity changes of ...
-
Article
A novel member of the Rhomboid family, RHBDD1, regulates BIK-mediated apoptosis
Rhomboid family members are widely conserved and found in all three kingdoms of life. They are serine proteases and serve important regulatory functions. In the present study, a novel gene highly expressed in ...
-
Article
In Silico Construction of a Protein Interaction Landscape for Nucleotide Excision Repair
To obtain a systems-level perspective on the topological and functional relationships among proteins contributing to nucleotide excision repair (NER) in Saccharomyces cerevisiae, we built two models to analyze pr...
-
Article
Deletion analysis of the C-terminal region of a molecular chaperone DnaK from Bacillus licheniformis
Bacillus licheniformis DnaK (BlDnaK) is predicted to consist of a 45-kDa N-terminal ATPase domain and a 25-kDa C-terminal substrate-binding domain. In this study, the full-length BlDnaK and its T86W and three C-t...
-
Article
Open AccessCharacterization of bovine miRNAs by sequencing and bioinformatics analysis
MicroRNAs (miRNAs) are a family of ~22 nucleotide small RNA molecules which regulate gene expression by fully or partially binding to their complementary sequences in mRNAs or promoters. A large number of miRN...
-
Article
The emergence of pandemic influenza viruses
Pandemic influenza has posed an increasing threat to public health worldwide in the last decade. In the 20th century, three human pandemic influenza outbreaks occurred in 1918, 1957 and 1968, causing significa...
-
Article
Open AccessCharacterization of microRNA expression in bovine adipose tissues: a potential regulatory mechanism of subcutaneous adipose tissue development
MicroRNAs (miRNAs), a family of small non-coding RNA molecules, appear to regulate animal lipid metabolism and preadipocyte conversion to form lipid-assimilating adipocytes (i.e. adipogenesis). However, no miRNA ...
-
Article
Interaction of Hsp40 with influenza virus M2 protein: implications for PKR signaling pathway
Influenza virus contains three integral membrane proteins: haemagglutinin, neuraminidase, and matrix protein (M1 and M2). Among them, M2 protein functions as an ion channel, important for virus uncoating in en...
-
Article
hNUDT16: a universal decap** enzyme for small nucleolar RNA and cytoplasmic mRNA
Human NUDT16 (hNUDT16) is a decap** enzyme initially identified as the human homolog to the Xenopus laevis X29. As a metalloenzyme, hNUDT16 relies on divalent cations for its cap-hydrolysis activity to remove m
-
Article
The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis
Tuberous sclerosis complex (TSC)1 and TSC2 are tumor suppressors that inhibit cell growth and mutation of either gene causes benign tumors in multiple tissues. The TSC1 and TSC2 gene products form a functional...
-
Article
Structural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1a
The guanine-nucleotide exchange factor (GEF) RalGPS1a activates small GTPase Ral proteins such as RalA and RalB by stimulating the exchange of Ral bound GDP to GTP, thus regulating various downstream cellular ...
-
Article
The Immunoproteasomes Regulate LPS-Induced TRIF/TRAM Signaling Pathway in Murine Macrophages
We have proposed the novel concept that the macrophage ubiquitin–proteasome pathway functions as a key regulator of Lipopolysaccharide (LPS)-induced inflammation signaling. These findings suggest that proteaso...
