13,230 Result(s)

Article

Embryo research tests NIH's mettle

One of the most contentious issues facing the NIH this year will be deciding what types of human embryo research should receive federal funds. President Bill Clinton has already ruled out one whole area.

Helen Gavaghan in Nature Medicine (1995)

Article

The gene as the drug

Caplen et al. (pages 39–46) demonstrate that it is feasible to use liposomes to transfer a human gene in vivo. Can this vector mimic the ability of viruses to effectively transfer genetic information into target ...

Ronald G. Crystal in Nature Medicine (1995)

Article

The Hot Zone: The Coming Plague

Edwin D. Kilbourne in Nature Medicine (1995)

Article

Medical informatics in clinical medicine and the biosciences

Perry L. Miller in Nature Medicine (1995)

Article

Lesion versus lumen

Skinner and colleagues (pages 69–73) show that MRI can be used to evaluate atherosclerotic lesions, non-invasively and in vivo

Peter Libby in Nature Medicine (1995)

Article

The form and the substance

By careful microscopic examination of in vitro fertilization (pages 47–52) Simerly et al. demonstrate the paternal origin of the human centrosome and reveal steps at which fertilization may fail.

Tim Stearns in Nature Medicine (1995)

Article

Coxsackieviruses and diabetes

Two recent reports provide further evidence for a link between coxsackieviruses and the onset of IDDM, although a careful examination suggests it is still too early to conclude a definitive role.

Michele Solimena, Pietro De Camilli in Nature Medicine (1995)

Article

Angiogenesis in cancer, vascular, rheumatoid and other disease

Recent discoveries of endogenous negative regulators of angiogenesis, thrombospondin, angiostatin and glioma-derived angiogenesis inhibitory factor, all associated with neovascularized tumours, suggest a new p...

Judah Folkman in Nature Medicine (1995)

Article

The serum concentration of active transforming growth factor-β is severely depressed in advanced atherosclerosis

Recent evidence has led us to propose that transforming growth factor-β (TGF-β) is a key inhibitor of atherosclerosis. We show here that a population of patients with advanced atherosclerosis all have less act...

David J. Grainger, Paul R. Kemp, James C. Metcalfe, Alexander C. Liu… in Nature Medicine (1995)

Article

Purification and expansion of human Schwann cells in vitro

The ability to culture cells from the human nervous system provides new insight into the pathophysiology of neurological diseases and could be crucial to the development of gene replacement therapies and neura...

J. Lynn Rutkowski, Cassandra J. Kirk, Miriam A. Lerner… in Nature Medicine (1995)

Article

Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis

We report the results of a double-blind, placebo-controlled trial in nine cystic fibrosis (CF) subjects receiving cationic liposome complexed with a complementary DNA encoding the CF transmembrane conductance ...

Natasha J. Caplen, Eric W.F.W. Alton, Peter G. Mddleton, Julia R. Dorin… in Nature Medicine (1995)

Article

Elimination of Ehrlich tumours by ATP-induced growth inhibition, glutathione depletion and X-rays

ATP-induced tumour growth inhibition is accompanied by a selective decrease in the content of the tripeptide glutathione (CSH) within the cancer cells in vivo. Depletion of cellular GSH sensitizes tumours to chem...

José M. Estrela, Elena Obrador, José Navarro, M. Carmen Lasso De La Vega… in Nature Medicine (1995)

Article

Clinical trials in Japan

Although Japan's clinical trial system mimics that of the United States, there are certain flaws in the Japanese regulations that prevent it from working effectively.

Masanori Fukushima: Tokyo in Nature Medicine (1995)

Article

The paternal inheritance of the centrosome, the cell's microtubule-organizing center, in humans, and the implications for infertility

Successful fertilization in humans, achieved when parental chromosomes intermix at first mitosis, requires centrosome restoration and microtubule-mediated motility. Imaging of inseminated human oocytes reveals...

Calvin Simerly, Gwo-Jang Wu, Sara Zoran, Teri Ord, Richard Rawlins… in Nature Medicine (1995)