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Open AccesseIF4E phosphorylation mediated LPS induced depressive-like behaviors via ameliorated neuroinflammation and dendritic loss
The translational defect has emerged as a common feature of neurological disorders. Studies have suggested that alterations between opposing and balanced synaptic protein synthesis and turnover processes could...
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Article
A novel framework of credit risk feature selection for SMEs during industry 4.0
With the development of industry 4.0, the credit data of SMEs are characterized by a large volume, high speed, diversity and low-value density. How to select the key features that affect the credit risk from t...
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Open AccessCryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state
The conserved ATPase p97 (Cdc48 in yeast) and adaptors mediate diverse cellular processes through unfolding polyubiquitinated proteins and extracting them from macromolecular assemblies and membranes for disag...
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Open AccessStudy on selection of native greening plants based on eye-tracking technology
The selection of native greening plants to improve rural greening technology is crucial for enriching methods of building rural plant landscapes. However, there are few studies from the perspective of visual p...
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Open AccessDietary supplement of Yunkang 10 green tea and treadmill exercise ameliorate high fat diet induced metabolic syndrome of C57BL/6 J mice
Diet and exercise play important roles in ameliorating metabolic syndrome. Yunkang 10 (Camellia sinensis var. assamica) is a most cultivated tea variety for making tea in the Southwestern China. Currently, there ...
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Open AccessOverestimated climate warming and climate variability due to spatially homogeneous CO2 in climate modeling over the Northern Hemisphere since the mid-19th century
Since the mid-19th century, the global atmospheric CO2 concentration (ACC) has increased dramatically due to the burning of fossil fuels. Because of unequal population growth and economic development among region...
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Open AccessThe roles of kinetochore of micronucleus in mitosis of HeLa cells: a live cell imaging study
Micronuclei (MNi) are extensively used to evaluate genotoxic effects and chromosome instability. However, the roles of kinetochore of MN in mitosis have not been completely addressed.
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Open AccessThe tea plant reference genome and improved gene annotation using long-read and paired-end sequencing data
Tea is a globally consumed non-alcohol beverage with great economic importance. However, lack of the reference genome has largely hampered the utilization of precious tea plant genetic resources towards breedi...
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Open AccessMechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing
The spindle checkpoint maintains genomic stability and prevents aneuploidy. Unattached kinetochores convert the latent open conformer of the checkpoint protein Mad2 (O-Mad2) to the active closed conformer (C-M...
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Open AccessThe proposed biosynthesis of procyanidins by the comparative chemical analysis of five Camellia species using LC-MS
The genus Camellia (C.) contains many species, including C. sinensis, C. assamica, and C. taliensis, C. gymnogyna and C. tachangensis. The polyphenols of C. sinensis and C. assamica are flavan-3-ols monomers and ...
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Open AccessUltrahigh Oxidation Resistance and High Electrical Conductivity in Copper-Silver Powder
The electrical conductivity of pure Cu powder is typically deteriorated at elevated temperatures due to the oxidation by forming non-conducting oxides on surface, while enhancing oxidation resistance via alloy...
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Open AccessStructural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins
Optineurin is an important autophagy receptor involved in several selective autophagy processes, during which its function is regulated by TBK1. Mutations of optineurin and TBK1 are both associated with neurod...
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Open AccessOuabain prevents pathological cardiac hypertrophy and heart failure through activation of phosphoinositide 3-kinase α in mouse
Use of low doses of digitalis to prevent the development of heart failure was advocated decades ago, but conflicting results of early animal studies dissuaded further research on this issue. Recent discoverie...