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Open AccessTAK1 inhibition attenuates both inflammation and fibrosis in experimental pneumoconiosis
Pneumoconiosis, caused by inhalation of mineral dusts, is a major occupational disease worldwide. Currently, there are no effective drugs owing to a lack of potential therapeutic targets during either the infl...
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Article
Open AccessSequence determinants of specific pattern-recognition of bacterial ligands by the NAIP–NLRC4 inflammasome
The NLR apoptosis inhibitory proteins (NAIPs) function as specific cytosolic receptors for bacterial ligands to form the NAIP–NLRC4 inflammasome for anti-bacterial defenses. In mice, NAIP5/6 and NAIP2 recogniz...
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Article
Open AccessCoxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses
Coxsackievirus A10 (CV-A10) belongs to the Enterovirus species A and is a causative agent of hand, foot, and mouth disease. Here we present cryo-EM structures of CV-A10 mature virion and native empty particle (NE...
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Article
Open AccessDysregulated hematopoiesis in bone marrow marks severe COVID-19
Severe coronavirus disease 2019 (COVID-19) is often indicated by lymphopenia and increased myelopoiesis; however, the underlying mechanism is still unclear, especially the alteration of hematopoiesis. It is im...
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Open AccessEstablishment of human distal lung organoids for SARS-CoV-2 infection
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Open AccessGenome-wide association and functional interrogation identified a variant at 3p26.1 modulating ovarian cancer survival among Chinese women
Ovarian cancer survival varies considerably among patients, to which germline variation may also contribute in addition to mutational signatures. To identify genetic markers modulating ovarian cancer outcome, ...
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Article
Open AccessEnhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding
Little is known regarding why a subset of COVID-19 patients exhibited prolonged positivity of SARS-CoV-2 infection. Here, we found that patients with long viral RNA course (LC) exhibited prolonged high-level I...
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Open AccessA novel recombination protein C12ORF40/REDIC1 is required for meiotic crossover formation
During meiosis, at least one crossover must occur per homologous chromosome pair to ensure normal progression of meiotic division and accurate chromosome segregation. However, the mechanism of crossover format...